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第45卷第9期 周张迪,张译心,戴嘉懿,等. 基于甲襞微循环特征的结缔组织病患者肺动脉高压风险评估研究[J].
2025年9月 南京医科大学学报(自然科学版),2025,45(9):1276-1285 ·1283 ·
(续表3)
Variable Low risk(n=13) Intermediate risk(n=24) High risk(n=15) P
Subpapillary venous plexus visibility[n(%)] 0 0.003
Not visible 0 007(53.8) 19(79.2)000 0.09(60.0)
1 row visible 0 004(30.8) 4(16.7)00 0.00(0)
2 row visible 0 002(15.4) 0(0)0000. 0.06(40.0)
>2 rows,dilated 0 000(0) 1(4.1)000 0.00(0)
Morphology score[M(P25,P75)] 02.80(1.30,5.90) 3.60(1.60,5.32) 1.60(0.75,5.90) 0.666
Flow pattern score[M(P25,P75)] 01.00(0.60,2.20) 0.60(0.20,2.60) 0.60(0.50,5.00) 0.503
Pericapillary score[M(P25,P75)] 02.00(0.80,3.20) 2.00(0.70,3.68) 2.30(1.95,5.40) 0.303
Semi⁃quantitative assessment[n(%)] 0.800
Normal 0 000(0) 3(12.5)00 0.00(0)
Essentially normal 0 000(0) 1(4.2)000 0.02(13.3)
Mild abnormal 0 004(30.8) 5(20.8)00 0.04(26.7)
Major abnormal 0 004(30.8) 6(25.0)00 0.03(20.0)
Severe abnormal 0 005(38.4) 9(37.5)00 0.06(40.0)
For the abbreviations,please see those in Table 1.
为提高研究结果的可靠性,本研究通过控制环境温 experiments,conducting the study,critically reviewing the intel⁃
度、实施标准化宣教等措施减少外界干扰,并通过 lectual content of the article,and researching funding support.
控制患者的年龄、性别等混杂变量,从而有效提升 [参考文献]
结果的可信度。
[1] HASSOUN P M. Pulmonary arterial hypertension[J]. N
由于样本量的限制,本研究所构建的预测模型 Engl J Med,2021,385(25):2361-2376
尚未得到验证,目前仅为开发队列的研究。未来研 [2] HUMBERT M,KOVACS G,HOEPER M M,et al. 2022
究中将进一步扩大样本量,并开展多中心研究,力 ESC/ERS Guidelines for the diagnosis and treatment of
争完善该预测模型,增强结果的普适性,并探索甲 pulmonary hypertension[J]. Eur Respir J,2023,61(1):
襞微循环在CTD⁃PAH预后中的潜在价值。 2200879
利益冲突声明: [3] LYNCH J P R,BELPERIO J A,SAGGAR R,et al. Pulmo⁃
所有作者均声明不存在利益冲突。 nary hypertension complicating connective tissue dis⁃
Conflict of Interests: ease[J]. Semin Respir Crit Care Med,2013,34(5):581-
599
The authors declare no competing interests.
作者贡献声明: [4] HAO Y,JIANG X,ZHOU W,et al. Connective tissue dis⁃
周张迪负责酝酿和设计实验、实施研究、采集数据、分析 ease ⁃ associated pulmonary arterial hypertension in Chi⁃
及解释数据、论文撰写;张译心、戴嘉懿、李冬玉负责采集数 nese patients[J]. Eur Respir J,2014,44(4):963-972
据、分析及解释数据、统计分析;孙晓萱负责酝酿和设计实 [5] SMITH V,HERRICK A L,INGEGNOLI F,et al. Standar⁃
验、实施研究、对文章的知识性内容作批判性审阅;王嫱负责 disation of nailfold capillaroscopy for the assessment of
酝酿和设计实验、实施研究、对文章的知识性内容作批判性 patients with Raynaud’s phenomenon and systemic scle⁃
审阅、研究经费支持。 rosis[J]. Autoimmun Rev,2020,19(3):102458
Author’s Contributions: [6] 国家风湿病数据中心,中国系统性红斑狼疮研究协作
组. 中国成人系统性红斑狼疮相关肺动脉高压诊治共
ZHOU Zhangdi was responsible for conceiving and design⁃
ing the experiments,conducting the study,collecting data,ana⁃ 识[J]. 中华内科杂志,2015,54(1):81-86
lyzing and interpreting the data,and writing the manuscript; National Rheumatoid Disease Data Center,Chinese Col⁃
ZHANG Yixin,DAI Jiayi,and LI Dongyu were responsible for laborative Group for Systemic Lupus Erythematosus. Con⁃
collecting data,analyzing and interpreting the data,and perform⁃ sensus on diagnosis and treatment of systemic lupus ery⁃
ing statistical analysis. SUN Xiaoxuan was responsible for con⁃ thematosus ⁃ related pulmonary arterial hypertension in
ceiving and designing the experiments,conducting the study, Chinese adults[J]. Chinese Journal of Internal Medicine,
and critically reviewing the intellectual content of the article. 2015,54(1):81-86
WANG Qiang was responsible for conceiving and designing the [7] 田 牛. 临床微循环检查手册[M]. 北京:中国医药科

