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Reference ［ 59 ］ ［ 60 ］ ［ 61 ］ ［ 62 ］ ［ 63 ］ ［ 39 ］ ［ 38 ］ ［ 64 ］ ［ 66 ］ ［ 68 ］ ［ 70 ］ ［ 71 ］ ［ 73 ］ ［ 72 ］ ［ 37 ］ ［ 76 ］ ［ 78 ］ ［ 79 ］ ［ 82 ］
to pro⁃ and
Functional impact Involved in PCOS development and Participates in PCOS pathological Affects follicular development Regulates ovarian steroidogenesis Affects cholesterol metabolism in Potentially associated with abnormal Inhibits granulosa cell apoptosis and Improves inflammatory status of Impairs embryo attachment Causes embryonic arrest at the decidualization， leading abnormal embryo implantation May be a key pathogenic mechanism of RIF Associated with dimini
reproductive progression process Increases risk of PCOS Increases risk of PCOS ovarian granulosa cells lipid metabolism in PCOS restores ovarian function granulosa cells morula stage with Interferes cells， Inhibits
female axon miR⁃1294 inhibits phagocytosis mitochondrial PTEN， activates
with with and upregulates and TLR4 and etc. ）
associated Target/Signaling pathway Regulates oxidative stress and cell proliferation in granulosa cells Inhibits granulosa cell proliferation Regulates glycolysis in granulosa cells Modulates MAPK signaling， and circadian rhythm network ceRNA Insulin/MAPK signaling pathway regulates Downregulates FOXO1 Abnormal exosome secretion and mediated and mTOR signaling pathway glycolytic Targets and inhibits SLC7A11 inhibits and Regulates apoptosis related genes Tr
molecules guidance， Forms and CYP19A1 Binds miR⁃4644 LDLR expression - Targets PDCD4 Negatively κB pathway NF Regulates IGF1R - function receptor Fcγ Regulates gene transcription Targets PI3K/AKT pathway Irak， （ Bim，
bioactive 女性生殖疾病相关外泌体非编码RNA及其他生物活性分子
other Sample source Follicular fluid Follicular fluid Follicular fluid Plasma exosomal Follicular fluid Follicular fluid Follicular fluid exosomes(obese PCOS Urinary exosomes Stem cell exosomes Stem cell exosomes Endometrial exosomes Endometrial exosomes Plasma derived exosomes Endometrial exosomes Follicular fluid exosomes Follicular fluid exosomes Serum exosomes Stem cell exosomes Stem cell exosomes
and exosomes exosomes exosomes exosomes exosomes patients）
RNAs CD9↑
coding （ ADSCs derived） （ hUC MSCs in （ BMSCs derived） （ AFSCs derived）
表1 non Expression/Functional change Differentially expressed Androgen induced specific upregulation Differentially expressed Significantly elevated Aberrant expression Decreased expression Significantly differentially Elevated level Significantly elevated Aberrant expression Differentially expressed and CD9↓ proliferative phase； in secretory phase Significantly upregulated Significantly downregulated Significantly downregulated in older women
Exosomal Decreased expressed Delivered Delivered derived） CD63↑ Carried Delivered Delivered
1 miR⁃106a⁃5p，
Table PTOV1⁃AS1， SNHG14， miR⁃122⁃5p，
Molecule name miR⁃143⁃3p/miR⁃155⁃5p others and others miR⁃146a
miR⁃4449 miR⁃379⁃5p miR⁃146a⁃5p， miR⁃126⁃3p miR⁃20b⁃5p， miR⁃18a⁃3p hsa⁃circ⁃0006877 circ_0008285 TPT1⁃AS1， PTPRG⁃AS1， 16 and DENND1A.V2 miR⁃323⁃3p miR⁃100 miR⁃145 miR⁃218⁃5p miR⁃183⁃5p CD9 CD63， miR⁃625⁃3p， miR⁃675⁃3p， others 17 miR⁃1246， 33 and miR⁃320a⁃3p miR⁃132⁃5p miR⁃144⁃5p miR⁃10a，
Molecule type miRNA miRNA miRNA miRNA miRNA circRNA circRNA lncRNA RNA miRNA （ therapeutic） miRNA （ therapeutic） miRNA miRNA miRNA Surface marker miRNA miRNA miRNA miRNA （ treatment） miRNA （ treatment）
Disease PCOS RIF DOR/POF
