Page 160 - 南京医科大学自然版
P. 160
第46卷第4期
·628 · 南 京 医 科 大 学 学 报 2026年4月
of the role of high⁃frequency mutant subunits of the SWI/ the mammalian SWI/SNF ATPase BRG1[J]. Front Cell
SNF complex in tumors[J]. Front Oncol,2024,14:1463892 Dev Biol,2023,11:1160227
[12]ABU SAILIK F,EMERALD B S,ANSARI S A. Opening [23]ROBINSON G,PARKER M,KRANENBURG T A,et al.
and changing:mammalian SWI/SNF complexes in organ Novel mutations target distinct subgroups of medulloblas⁃
development and carcinogenesis[J]. Open Biol,2024,14 toma[J]. Nature,2012,488(7409):43-48
(10):240039 [24]AGAIMY A. SWI/SNF⁃deficient sinonasal carcinomas[J].
[13]CONCEPCION C P,MA S,LAFAVE L M,et al. Smarca4 Adv Anat Pathol,2023,30(2):95-103
inactivation promotes lineage⁃specific transformation and [25]DONG W,DAI A L,WU Z J,et al. Successful treatment
early metastatic features in the lung[J]. Cancer Discov, with tislelizumab plus chemotherapy for SMARCA4⁃defi⁃
2022,12(2):562-585 cient undifferentiated tumor:a case report[J]. Front Im⁃
[14]XUE Y B,MORRIS J L,YANG K N,et al. SMARCA4/2 munol,2024,15:1371379
loss inhibits chemotherapy⁃induced apoptosis by restrict⁃ [26]CHI S N,YI J S,WILLIAMS P M,et al. Tazemetostat for
ing IP3R3⁃mediated Ca(2+)flux to mitochondria[J]. Nat tumors harboring SMARCB1/SMARCA4 or EZH2 altera⁃
Commun,2021,12(1):5404 tions: results from NCI ⁃ COG pediatric MATCH
[15]XUE Y B,MEEHAN B,FU Z,et al. SMARCA4 loss is APEC1621C[J]. J Natl Cancer Inst,2023,115(11):
synthetic lethal with CDK4/6 inhibition in non⁃small cell 1355-1363
lung cancer[J]. Nat Commun,2019,10(1):557 [27]ZHANG M Z,DONG Y H,MENG R,et al. SMARCA4 de⁃
[16]董荣芳,郭 稳,李 楠,等. 神经肌肉迷芽瘤相关的韧 ficiency in lung cancer:from signaling pathway to poten⁃
带样型纤维瘤病临床病理及分子遗传学特征[J]. 中华 tial therapeutic targets[J]. Genes Chromosomes Cancer,
病理学杂志,2024,53(7):685-690 2025,64(1):e70022
DONG R F,GUO W,LI N,et al. Clinicopathological and [28]ROMERO O A,VILARRUBI A,ALBURQUERQUE⁃BE⁃
molecular genetic features of neuromuscular choristoma⁃ JAR J J,et al. SMARCA4 deficient tumours are vulnera⁃
associated desmoid type fibromatosis[J]. Chinese Journal ble to KDM6A/UTX and KDM6B/JMJD3 blockade[J].
of Pathology,2024,53(7):685-690 Nat Commun,2021,12:4319
[17]DANTZER C,DIF L,VACHÉ J,et al. Specific features of [29]ABOU A S,NASSAR A H,XIE W L,et al. Mammalian
β ⁃ catenin ⁃ mutated hepatocellular carcinomas[J]. Br J SWI/SNF complex genomic alterations and immune
Cancer,2024,131(12):1871-1880 checkpoint blockade in solid tumors[J]. Cancer Immunol
[18]XU C R,XU Z,ZHANG Y,et al. β⁃Catenin signaling in Res,2020,8(8):1075-1084
hepatocellular carcinoma[J]. J Clin Invest,2022,132 [30]COOPER G W,HONG A L. SMARCB1⁃deficient cancers:
(4):e154515 novel molecular insights and therapeutic vulnerabilities[J].
[19]NEIL A J,ZHAO L,ISIDRO R A,et al. SMARCA4 muta⁃ Cancers,2022,14(15):3645
tions in carcinomas of the esophagus,esophagogastric [31]NUSSE R,CLEVERS H. Wnt/β ⁃ catenin signaling,dis⁃
junction,and stomach[J]. Mod Pathol,2023,36(6): ease,and emerging therapeutic modalities[J]. Cell,2017,
100183 169(6):985⁃999
[20]GÖBEL C,SCHOOF M,HOLDHOF D,et al. SMARCA4 [32]SHAH K,PANCHAL S,PATEL B. Porcupine inhibitors:
loss and mutated β⁃catenin induce proliferative lesions in Novel and emerging anti⁃cancer therapeutics targeting the
the murine embryonic cerebellum[J]. J Neurosci,2024, Wnt signaling pathway[J]. Pharmacol Res,2021,167:
44(15):e1605232024 105532
[21]MOSIMANN C,HAUSMANN G,BASLER K. β⁃Catenin [33]PARK W J,JONG K. A new wave of targeting‘undrugga⁃
hits chromatin:regulation of Wnt target gene activation[J]. ble’Wnt signaling for cancer therapy:challenges and op⁃
Nat Rev Mol Cell Biol,2009,10(4):276-286 portunities[J]. Cells,2023,12(8):1110
[22]SHARMA T,OLEA⁃FLORES M,IMBALZANO A N. Regu⁃ (收稿:2025-07-12;修回:2025-12-20;录用:2025-12-23)
lation of the Wnt signaling pathway during myogenesis by (本文编辑:戴王娟)

