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第46卷第4期 李 云，孙阳阳，王更芳，等. 1例鼻窦SMARCA4 缺失性癌伴颅内侵袭临床病理学分析［J］.
2026年4月 南京医科大学学报（自然科学版），2026，46（4）：622-628 ·625 ·

表1 鼻窦SMARCA4缺失性癌的临床特征文献报道汇总表
Summary Table of Literature Reports on Clinical Characteristics of Sinonasal SMARCA4⁃Deficient Carcinoma
Size TNM/ SMARCA2
References Age/sex Site Treatment Survival（month）
（cm）metastasis expression
AGAIMY A ［2］ 40/F right nasal cavity，sinuses；skull base NA T4N2M0 Surgery+RT+CT AWD（9） Reduced
and periorbital extension
40/F right nasal cavity，sinuses NA T4N2M0 Surgery+RT AWD（9） Reduced
50/M left nasal cavity NA NA NA NA Retained
20/M left nasal cavity NA T4NXM1 CT DOD（3） Loss
47/M sinonasal unspecified NA T4NxM1 CT AWD（8） Retained
30/M nasal cavity NA NA NA NA Retained
［9］
AGAIMY A 41/M nasal cavity NA NA NA NA Retained
51/F sinonasal unspecified NA NA Surgery Died 3 mo after surgery Retained
before planned RT
42/F left nasal cavity and maxillary sinus NA T4NxM1 CT Died of progressive lung Retained
disease at 7 mo
67/M right nasal cavity NA T4NxMx NA NA ND
54/M left nasal cavity NA T4NxMx Biopsy only DOD（1） ND
KAKKAR A ［1］ 48/M bilateral nasal cavities，sphenoid，eth⁃ NA NA Surgery+RT+CT AWD（35） Retained
moid mass with intracranial extension
70/M right nasal cavity NA NA CT DOD（9） Retained
30/M left nasal cavity；intracranial extension NA NA CT AWD（34） Retained
43/M sinonasal mass，unspecified，with in⁃ NA NA Surgery+RT+CT DOD（34） Retained
tracranial extension
30/M nasal cavity NA NA Surgery+CT DOD（14） Retained
25/M left nasal cavity NA NA Surgery NA Retained
45/F right nasal mass NA NA Surgery NA Retained
28/M left nasal cavity mass，intracranial ex⁃ NA NA Surgery AWD（7） Retained
tension
22/M left sinonasal mass with intracranial NA NA Biopsy only AWD ND
extension
LI C ［7］ 31/M left nasal cavity 3.3 NA Surgery+RT+CT AWD（5） ND
［3］
ZHAO M 83/M right nasal cavity，ethmoid sinus；max⁃ 4.4 T4N0M0 Surgery+RT+CT DOD（12） Retained
illary sinus，skullbase and periorbital
tissue
61/F left nasal cavity，ethmoid sinus；left 4.6 T4N0M0 Surgery+RT+CT DOD（4） Retained
frontal sinus，maxillary sinus and the
skull base
［4］
KANG H G 47/F nasalcavity NA T4bNxM0 Surgery+CT AWD（10.4） ND
50/M nasalcavity NA TxN2bM0 Surgery+RT AWD（5.6） ND
34/M left nasal cavity，maxillary sinus，orbit； NA NA RT+CT DOD（6） ND
intracranium
ZHU H J ［6］ 64/M slope at the base of the middle cranial NA NA Surgery+CT AWD（6） ND
fossa
［8］
KE Q L 60/M right nasal cavity，ethmoidal sinus 4 NA Surgery+RT+CT AWD ND
XU X N ［5］ 65/M nasal cavity，ethmoid，sphenoid，skull⁃ NA T4N0M0 Surgery+CT DOD ND
base，brain
Our case 70/M nasal cavity，bilateral ethmoid sinuses 6.5 T4NxMx Surgery DOD（3） ND
and left frontal lobe

NA，not available；CT，Chemotherapy；RT，radiotherapy；AWD，alive with disease；DOD，died of disease；ND，not done.