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第46卷第8期 刘斐然,冒韵东,刁飞扬. 代谢组学在子宫内膜异位症研究中的应用进展[J].
2026年8月 南京医科大学学报(自然科学版),2026,46(8):1228-1245 ·1241 ·
dysfunc⁃ stress al⁃ in⁃ and me⁃ ado⁃ of pa⁃ with rAFS dis⁃
and oxidative endometriosis show levels;involved in endometriosis serum with promotes
Function significance - - Mitochondrial and tion marker - - Identifiedaskeybiomar⁃ for kers - types Multiple tered signaling cell in flammation Anti ⁃ inflammatory altered tabolite; lescent patients Identifiedaskeybiomar⁃ kers for endometriosis - - in Elevated endometriosis deep tients;associated process fibrosis - Correlates and stage progression ease
Other samples - - (Dried ↑ menstrual spots, blood [40] DMBS) [25] (CC) ↑ - (DMBS) ↓ [42] [40] ,(EF) ↓ [40] (DMBS) ↑ - - - - - - - -
Tissue sample - - - - [26] ↑ - - (Ⅱ- [11] Ⅲ) - - - [11] (Ⅱ) - -
↓
↑
Urine - - - - - - - - - - - - - -
Peritoneal fluid - - - - - (Ⅰ-Ⅳ) ↑ [ 28 ] ↑ 15, 27 ] , [ [22] ↑ - - [ 28 (Ⅰ-Ⅳ) ] ↑ - - - - [ 43 (Ⅰ-Ⅳ) ] ↑
Endometrial fluid - - - - - - ⁃ - - - - - - - -
[20] (Ⅲ, [18] ,(Ⅲ, [50] Ⅳ)
Follicular fluid [23] ↑ - - - (Ⅰ-Ⅳ) ↑ , [49] Ⅳ) - (Ⅰ-Ⅳ) [23] ↑ [50] Ⅳ) - - - ,(Ⅰ- ↓ [18] Ⅳ) [9] ↓ (Ⅲ,
↑ [23] ↑ ↑ ↑ [23] ↑ ↑
[35] 37]
Plasma - (Ⅲ) ↑ - [36] ↑ - 27, [15, ↑ - - [36] ↓ - (Ⅲ, ↑ [51] Ⅳ) [36] ↓ - - -
↑ , [17]
Serum - - - - - - - - - - - - [31] (Ⅳ) (Ⅰ-Ⅳ) - -
↑
Category metabolites metabolites metabolites acids metabolites acids acids acids acids
Lipid Lipid Lipid Fatty Phospholipids Phospholipids Lipid Lipids Amino Dipeptides Phospholipids acids Bile Amino Amino Organic
Metabolite cardiolipin acid Phosphatidylinositol Phosphatidylcholine Phosphoethanolamine Phenylalanyl⁃isoleucine acids bile
(续表1) Oleamide Oleylcarnitine Oxidized Palmitic Phospholipids Phenylalanine Plasmenylcholines Primary Proline Serine Succinate

