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第46卷第8期               刘斐然,冒韵东,刁飞扬. 代谢组学在子宫内膜异位症研究中的应用进展[J].
                  2026年8月                     南京医科大学学报(自然科学版),2026,46(8):1228-1245                      ·1241 ·


                                dysfunc⁃  stress         al⁃  in⁃  and  me⁃  ado⁃            of  pa⁃  with  rAFS  dis⁃
                    and           oxidative        endometriosis  show  levels;involved  in  endometriosis  serum  with  promotes
                    Function  significance  -  -  Mitochondrial  and  tion  marker  -  -  Identifiedaskeybiomar⁃  for  kers  -  types Multiple  tered  signaling  cell  in  flammation  Anti ⁃ inflammatory  altered tabolite;  lescent  patients  Identifiedaskeybiomar⁃  kers for endometriosis  -  -  in Elevated  endometriosis  deep  tients;associated  process fibrosis  -  Correlates  and  stage  progression  ease








                    Other  samples  -  -  (Dried  ↑  menstrual  spots,  blood  [40]  DMBS)  [25]  (CC)  ↑  -  (DMBS)  ↓  [42]  [40] ,(EF)  ↓  [40] (DMBS)  ↑  -  -  -  -  -  -  -  -




                    Tissue  sample  -  -   -  -  [26]  ↑  -  -     (Ⅱ-  [11]  Ⅲ)  -  -    -  [11]  (Ⅱ)  -  -
                                                                   ↓
                                                                                             ↑
                      Urine  -  -          -  -  -    -  -         -          -     -     -  -         -  -

                    Peritoneal  fluid  -  -  -  -  -  (Ⅰ-Ⅳ)  ↑  [ 28 ] ↑ 15, 27 ]  , [  [22]  ↑  -  -  [ 28 (Ⅰ-Ⅳ) ]  ↑  -  -  -  -  [ 43 (Ⅰ-Ⅳ) ]  ↑




                    Endometrial  fluid  -  -  -  -  -  -  ⁃  -     -          -     -     -  -         -  -




                                             [20]  (Ⅲ,  [18]       ,(Ⅲ,                                  [50]  Ⅳ)
                    Follicular  fluid  [23]  ↑  -  -  -  (Ⅰ-Ⅳ)  ↑  ,  [49]  Ⅳ)  -  (Ⅰ-Ⅳ)  [23]  ↑  [50]  Ⅳ)  -  -  -  ,(Ⅰ-  ↓  [18]  Ⅳ)  [9]  ↓  (Ⅲ,


                                             ↑  [23]  ↑  ↑         ↑                        [23]  ↑       ↑
                            [35]               37]
                      Plasma  -  (Ⅲ)  ↑  -  [36]  ↑  -  27,  [15,  ↑  -  -  [36]  ↓  -  (Ⅲ,  ↑  [51]  Ⅳ)  [36]  ↓  -  -  -



                                                                                             ↑  ,  [17]
                      Serum  -  -  -       -  -  -    -  -         -          -     -     -  [31]  (Ⅳ)  (Ⅰ-Ⅳ)  -  -

                                                                                             ↑




                      Category  metabolites  metabolites  metabolites  acids  metabolites  acids  acids  acids  acids



                          Lipid  Lipid  Lipid  Fatty  Phospholipids  Phospholipids  Lipid  Lipids  Amino  Dipeptides  Phospholipids  acids  Bile  Amino  Amino  Organic





                      Metabolite  cardiolipin  acid  Phosphatidylinositol  Phosphatidylcholine  Phosphoethanolamine  Phenylalanyl⁃isoleucine  acids  bile



                 (续表1)    Oleamide  Oleylcarnitine  Oxidized  Palmitic  Phospholipids  Phenylalanine  Plasmenylcholines  Primary  Proline  Serine  Succinate
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