Page 139 - 南京医科大学自然版

第46卷第8期 刘斐然，冒韵东，刁飞扬. 代谢组学在子宫内膜异位症研究中的应用进展［J］.
2026年8月 南京医科大学学报（自然科学版），2026，46（8）：1228-1245 ·1245 ·

sis and infertility etiologies：a pilot study［J］. PeerJ，2026， 1521216
14：e20786 ［48］DA BROI M G，DE ALBUQUERQUE F O，DE AN⁃
［39］LI J J，GUAN L H，ZHANG H Z，et al. Endometrium me⁃ DRADE A Z，et al. Increased concentration of 8⁃hydroxy⁃
tabolomic profiling reveals potential biomarkers for diag⁃ 2′ ⁃ deoxyguanosine in follicular fluid of infertile women
nosis of endometriosis at minimal⁃mild stages［J］. Reprod with endometriosis［J］. Cell Tissue Res，2016，366（1）：
Biol Endocrinol，2018，16（1）：42 231-242
［40］STARODUBTSEVA N，CHAGOVETS V，TOKAREVA A， ［49］LUO T，WANG M Y，HE Y，et al. Metabolic profile of fol⁃
et al. Diagnostic value of menstrual blood lipidomics in licular fluid in patients with ovarian endometriosis under⁃
endometriosis：a pilot study［J］. Biomolecules，2024，14 going IVF：a pilot study［J］. Reprod Biomed Online，
（8）：899 2024，49（2）：103912
［41］QU Y J，CHEN M，WANG Y R，et al. Rapid screening of ［50］GUO H Y，ZHU Q Q，GAO H Y，et al. Metabolomics anal⁃
infertility⁃associated gynecological conditions via ambient ysis of follicular fluid in ovarian endometriosis women re⁃
glow discharge mass spectrometry utilizing urine metabolic ceiving progestin⁃primed ovary stimulation protocol for in
fingerprints［J］. Talanta，2024，274：125969 vitro fertilization［J］. Sci Rep，2023，13（1）：5747
［42］DOMÍNGUEZ F，FERRANDO M，DÍAZ⁃GIMENO P，et ［51］VOUK K，HEVIR N，RIBIC⁃PUCELJ M，et al. Discovery
al. Lipidomic profiling of endometrial fluid in women with of phosphatidylcholines and sphingomyelins as biomark⁃
ovarian endometriosis［J］. Biol Reprod，2017，96（4）： ers for ovarian endometriosis［J］. Hum Reprod，2012，27
772-779 （10）：2955-2965
［43］TIAN Q，RUAN J Y，WANG Y N，et al. Extracellular suc⁃ ［52］ZHE J，CAI Y X，BI Y K. Association between lipid accu⁃
cinate derived from ectopic milieu drives adhesion and mulation product and endometriosis：a cross ⁃ sectional
implantation growth of ectopic endometrial stromal cells study from NHANES 1999⁃2006［J］. PLoS One，2025，20
via the SUCNR1 signal in endometriosis［J］. Cell Com⁃ （5）：e0323932
mun Signal，2024，22（1）：82 ［53］MOLINA N M，JURADO⁃FASOLI L，SOLA⁃LEYVA A，et
［44］DAI C C，CAO Y W，XU Y R，et al. Serum metabolic fin⁃ al. Endometrial whole metabolome profile at the receptive
gerprinting for diagnosis and therapeutic applications of phase：influence of mediterranean diet and infertility［J］.
ovarian endometriosis［J］. iScience，2026，29（3）：114887 Front Endocrinol，2023，14：1120988
［45］BAHRAMI A，AYEN E，RAZI M，et al. Effects of atorvas⁃ ［54］MEIDYANA S，FEDORA K. Metabolomics as a candidate
tatin and resveratrol against the experimental endometrio⁃ for endometriosis biomarker：a systematic review［J］. Fer⁃
sis；evidence for glucose and monocarboxylate transport⁃ til Reprod，2024，6（1）：49-59
ers，neoangiogenesis［J］. Life Sci，2021，272：119230 ［55］LI S H，LOOBY N，CHANDRAN V，et al. Challenges in
［46］LIU J，YANG D X，PIAO C Y，et al. UPLC⁃Q⁃TOF/MS the metabolomics⁃based biomarker validation pipeline［J］.
based plasma metabolomics for identification of paeonol’s Metabolites，2024，14（4）：200
metabolic target in endometriosis［J］. Molecules，2023，28 ［56］REICHER L，SHILO S，GODNEVA A，et al. Deep pheno⁃
（2）：653 typing of health⁃disease continuum in the Human Pheno⁃
［47］WANG M，LIU W，ZHENG L W，et al. Broadening hori⁃ type Project［J］. Nat Med，2025，31（9）：3191-3203
zons：microbiota as a novel biomarker and potential treat⁃ （收稿：2026-01-22；修回：2026-03-31；录用：2026-04-10）
ment for endometriosis［J］. Front Microbiol，2025，16： （本文编辑：陈汐敏）