Page 126 - 南京医科大学自然版
P. 126

第46卷第9期
               ·1396 ·                           南 京    医 科 大 学 学         报                        2026年9月


                   release danger signals to stimulate immune cells[J]. Hepa⁃  Targeting cholesterol at different levels in the mevalonate
                   tology,2011,54(1):133-144                         pathway protects fatty liver against ischemia⁃reperfusion
             [21]PAN J J,OU Z B,CAI C,et al. Fatty acid activates    injury[J]. J Hepatol,2011,54(5):1002-1010
                   NLRP3 inflammasomes in mouse Kupffer cells through  [33]REINIERS M J,VAN GOLEN R F,VAN GULIK T M,et
                   mitochondrial DNA release[J]. Cell Immunol,2018,332:  al. Reactive oxygen and nitrogen species in steatotic hepa⁃
                   111-120                                           tocytes:a molecular perspective on the pathophysiology of
             [22]ZHANG N P,LIU X J,XIE L,et al. Impaired mitophagy   ischemia⁃reperfusion injury in the fatty liver[J]. Antioxid
                   triggers NLRP3 inflammasome activation during the pro⁃  Redox Signal,2014,21(7):1119-1142
                   gression from nonalcoholic fatty liver to nonalcoholic stea⁃  [34]HU Q N,WOOD C R,CIMEN S,et al. Mitochondrial da⁃
                   tohepatitis[J]. Lab Invest,2019,99(6):749-763     mage⁃associated molecular patterns(MTDs)are released
             [23]LUO X J,LI H G,MA L Q,et al. Expression of STING is  during hepatic ischemia reperfusion and induce inflamma⁃
                   increased in liver tissues from patients with NAFLD and  tory responses[J]. PLoS One,2015,10(10):e0140105
                   promotes macrophage⁃mediated hepatic inflammation and  [35]XIONG Y,CHEN J W,LIANG W,et al. Blockade of the
                   fibrosis in mice[J]. Gastroenterology,2018,155(6):  mitochondrial DNA release ameliorates hepatic ischemia⁃

                   1971-1984                                         reperfusion injury through avoiding the activation of cGAS⁃
             [24]WANG X X,RAO H Y,ZHAO J M,et al. STING expres⁃      Sting pathway[J]. J Transl Med,2024,22(1):796
                   sion in monocyte⁃derived macrophages is associated with  [36]GUPTA N A,KOLACHALA V L,JIANG R,et al. Mitiga⁃
                   the progression of liver inflammation and fibrosis in pa⁃  tion of autophagy ameliorates hepatocellular damage fol⁃
                   tients with nonalcoholic fatty liver disease[J]. Lab Invest,  lowing ischemia ⁃ reperfusion injury in murine steatotic
                   2020,100(4):542-552                               liver[J]. Am J Physiol Gastrointest Liver Physiol,2014,
             [25]ARUMUGAM S,LI B H,BOODAPATI S L T,et al. Mito⁃      307(11):G1088-G1099
                   chondrial DNA and the STING pathway are required for  [37]WANG H,GUO M N,REN B Y,et al. Circadian control
                   hepatic stellate cell activation[J]. Hepatology,2023,78  of hepatic ischemia/reperfusion injury via HSD17B13⁃me⁃
                  (5):1448-1461                                      diated autophagy in hepatocytes[J]. J Hepatol,2025,83
             [26]XU X M,QIU J,LI X Y,et al. Perilipin5 protects against  (3):750-767
                   non⁃alcoholic steatohepatitis by increasing 11⁃dodecenoic  [38]KANG S W S,BROWN L A,MILLER C B,et al. PLIN5
                   acid and inhibiting the occurrence of ferroptosis[J]. Nutr  phosphorylation orchestrates mitochondria lipid ⁃ droplet
                   Metab,2023,20(1):29                               coupling to control hepatic lipid flux and steatosis[J].
             [27]ZHAI Y,PETROWSKY H,HONG J C,et al. Ischaemia⁃       Nat Metab,2026,8(3):587-603
                   reperfusion injury in liver transplantation⁃from bench to  [39]GEMMINK A,DAEMEN S,KUIJPERS H J H,et al. Super⁃
                   bedside[J]. Nat Rev Gastroenterol Hepatol,2013,10(2):  resolution microscopy localizes perilipin 5 at lipid droplet⁃
                   79-89                                             mitochondria interaction sites and at lipid droplets juxta⁃
             [28]ABU⁃AMARA M,YANG S Y,TAPURIA N,et al. Liver         posing to perilipin 2[J]. Biochim Biophys Acta Mol Cell
                   ischemia/reperfusion injury:processes in inflammatory  Biol Lipids,2018,1863(11):1423-1432
                   networks ⁃ a review[J]. Liver Transplant,2010,16(9):  [40]MARTIN G,BOSCH M,COLL E,et al. Contact:charac⁃
                   1016-1032                                         terization of lipid droplet⁃mitochondrial contacts using fluo⁃
             [29]MACHADO I F,PALMEIRA C M,ROLO A P. Preserva⁃        rescence microscopy and image analysis[J]. F1000Res,
                   tion of mitochondrial health in liver ischemia/reperfusion  2021,10:263
                   injury[J]. Biomedicines,2023,11(3):948       [41]LI X,GAMUYAO R,WU M L,et al. A fluorogenic com⁃
             [30]GUPTA N A,KOLACHALA V L,JIANG R,et al. The glu⁃     plementation tool kit for interrogating lipid droplet⁃organ⁃
                   cagon⁃like peptide⁃1 receptor agonist Exendin 4 has a pro⁃  elle interaction[J]. J Cell Biol,2024,223(9):e202311126
                   tective role in ischemic injury of lean and steatotic liver  [42]BRASAEMLE D L,WOLINS N E. Isolation of lipid drop⁃
                   by inhibiting cell death and stimulating lipolysis[J]. Am  lets from cells by density gradient centrifugation[J]. Curr
                   J Pathol,2012,181(5):1693-1701                    Protoc Cell Biol,2016,72:3.15.1-3.15.13
             [31]NATIV N I,YARMUSH G,SO A,et al. Elevated sensitivity  [43]BENADOR I Y,VELIOVA M,MAHDAVIANI K,et al.
                   of macrosteatotic hepatocytes to hypoxia/reoxygenation  Mitochondria bound to lipid droplets have unique bioener⁃
                   stress is reversed by a novel defatting protocol[J]. Liver  getics,composition,and dynamics that support lipid drop⁃
                   Transpl,2014,20(8):1000-1011                      let expansion[J]. Cell Metab,2018,27(4):869-885
             [32]LLACUNA L,FERNÁNDEZ A,MONTFORT C V,et al.      [44]BERSUKER K,PETERSON C W H,TO M,et al. A prox⁃
   121   122   123   124   125   126   127   128   129   130   131