Page 126 - 南京医科大学自然版
P. 126
第46卷第9期
·1396 · 南 京 医 科 大 学 学 报 2026年9月
release danger signals to stimulate immune cells[J]. Hepa⁃ Targeting cholesterol at different levels in the mevalonate
tology,2011,54(1):133-144 pathway protects fatty liver against ischemia⁃reperfusion
[21]PAN J J,OU Z B,CAI C,et al. Fatty acid activates injury[J]. J Hepatol,2011,54(5):1002-1010
NLRP3 inflammasomes in mouse Kupffer cells through [33]REINIERS M J,VAN GOLEN R F,VAN GULIK T M,et
mitochondrial DNA release[J]. Cell Immunol,2018,332: al. Reactive oxygen and nitrogen species in steatotic hepa⁃
111-120 tocytes:a molecular perspective on the pathophysiology of
[22]ZHANG N P,LIU X J,XIE L,et al. Impaired mitophagy ischemia⁃reperfusion injury in the fatty liver[J]. Antioxid
triggers NLRP3 inflammasome activation during the pro⁃ Redox Signal,2014,21(7):1119-1142
gression from nonalcoholic fatty liver to nonalcoholic stea⁃ [34]HU Q N,WOOD C R,CIMEN S,et al. Mitochondrial da⁃
tohepatitis[J]. Lab Invest,2019,99(6):749-763 mage⁃associated molecular patterns(MTDs)are released
[23]LUO X J,LI H G,MA L Q,et al. Expression of STING is during hepatic ischemia reperfusion and induce inflamma⁃
increased in liver tissues from patients with NAFLD and tory responses[J]. PLoS One,2015,10(10):e0140105
promotes macrophage⁃mediated hepatic inflammation and [35]XIONG Y,CHEN J W,LIANG W,et al. Blockade of the
fibrosis in mice[J]. Gastroenterology,2018,155(6): mitochondrial DNA release ameliorates hepatic ischemia⁃
1971-1984 reperfusion injury through avoiding the activation of cGAS⁃
[24]WANG X X,RAO H Y,ZHAO J M,et al. STING expres⁃ Sting pathway[J]. J Transl Med,2024,22(1):796
sion in monocyte⁃derived macrophages is associated with [36]GUPTA N A,KOLACHALA V L,JIANG R,et al. Mitiga⁃
the progression of liver inflammation and fibrosis in pa⁃ tion of autophagy ameliorates hepatocellular damage fol⁃
tients with nonalcoholic fatty liver disease[J]. Lab Invest, lowing ischemia ⁃ reperfusion injury in murine steatotic
2020,100(4):542-552 liver[J]. Am J Physiol Gastrointest Liver Physiol,2014,
[25]ARUMUGAM S,LI B H,BOODAPATI S L T,et al. Mito⁃ 307(11):G1088-G1099
chondrial DNA and the STING pathway are required for [37]WANG H,GUO M N,REN B Y,et al. Circadian control
hepatic stellate cell activation[J]. Hepatology,2023,78 of hepatic ischemia/reperfusion injury via HSD17B13⁃me⁃
(5):1448-1461 diated autophagy in hepatocytes[J]. J Hepatol,2025,83
[26]XU X M,QIU J,LI X Y,et al. Perilipin5 protects against (3):750-767
non⁃alcoholic steatohepatitis by increasing 11⁃dodecenoic [38]KANG S W S,BROWN L A,MILLER C B,et al. PLIN5
acid and inhibiting the occurrence of ferroptosis[J]. Nutr phosphorylation orchestrates mitochondria lipid ⁃ droplet
Metab,2023,20(1):29 coupling to control hepatic lipid flux and steatosis[J].
[27]ZHAI Y,PETROWSKY H,HONG J C,et al. Ischaemia⁃ Nat Metab,2026,8(3):587-603
reperfusion injury in liver transplantation⁃from bench to [39]GEMMINK A,DAEMEN S,KUIJPERS H J H,et al. Super⁃
bedside[J]. Nat Rev Gastroenterol Hepatol,2013,10(2): resolution microscopy localizes perilipin 5 at lipid droplet⁃
79-89 mitochondria interaction sites and at lipid droplets juxta⁃
[28]ABU⁃AMARA M,YANG S Y,TAPURIA N,et al. Liver posing to perilipin 2[J]. Biochim Biophys Acta Mol Cell
ischemia/reperfusion injury:processes in inflammatory Biol Lipids,2018,1863(11):1423-1432
networks ⁃ a review[J]. Liver Transplant,2010,16(9): [40]MARTIN G,BOSCH M,COLL E,et al. Contact:charac⁃
1016-1032 terization of lipid droplet⁃mitochondrial contacts using fluo⁃
[29]MACHADO I F,PALMEIRA C M,ROLO A P. Preserva⁃ rescence microscopy and image analysis[J]. F1000Res,
tion of mitochondrial health in liver ischemia/reperfusion 2021,10:263
injury[J]. Biomedicines,2023,11(3):948 [41]LI X,GAMUYAO R,WU M L,et al. A fluorogenic com⁃
[30]GUPTA N A,KOLACHALA V L,JIANG R,et al. The glu⁃ plementation tool kit for interrogating lipid droplet⁃organ⁃
cagon⁃like peptide⁃1 receptor agonist Exendin 4 has a pro⁃ elle interaction[J]. J Cell Biol,2024,223(9):e202311126
tective role in ischemic injury of lean and steatotic liver [42]BRASAEMLE D L,WOLINS N E. Isolation of lipid drop⁃
by inhibiting cell death and stimulating lipolysis[J]. Am lets from cells by density gradient centrifugation[J]. Curr
J Pathol,2012,181(5):1693-1701 Protoc Cell Biol,2016,72:3.15.1-3.15.13
[31]NATIV N I,YARMUSH G,SO A,et al. Elevated sensitivity [43]BENADOR I Y,VELIOVA M,MAHDAVIANI K,et al.
of macrosteatotic hepatocytes to hypoxia/reoxygenation Mitochondria bound to lipid droplets have unique bioener⁃
stress is reversed by a novel defatting protocol[J]. Liver getics,composition,and dynamics that support lipid drop⁃
Transpl,2014,20(8):1000-1011 let expansion[J]. Cell Metab,2018,27(4):869-885
[32]LLACUNA L,FERNÁNDEZ A,MONTFORT C V,et al. [44]BERSUKER K,PETERSON C W H,TO M,et al. A prox⁃

