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第41卷第1期                           南京医科大学学报(自然科学版)
                  2021年1月                   Journal of Nanjing Medical University(Natural Sciences)     · 69  ·


               ·临床研究·

                常州地区青少年人群甲状腺体积与代谢相关指标的关系



                肖   扬 ,徐书杭 ,郭       玲 ,吕文君 ,冯宁霞 ,汪奇峰 ,茅晓东 ,陈国芳 ,黄华英 ,刘 超                        1*
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                1 南京中医药大学附属中西医结合医院(江苏省中医药研究院)内分泌科,江苏                          南京    210028;武进中医医院内分泌科,江
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                苏 常州     213100
               [摘   要] 目的:探讨青少年甲状腺体积与代谢指标的相关性。方法:选取江苏省常州市 1 097 例 12~15 岁青少年学生(男
                55.6%),进行体格检查、生化检测以及甲状腺超声检查。对比研究正常、超重、肥胖组青少年甲状腺体积大小,分析代谢综合
                征组分数量与甲状腺体积之间的关系,并进一步研究代谢相关指标与甲状腺体积的相关性。结果:男性超重组和肥胖组甲状
                腺体积与正常组相比差异均有统计学意义(P<0.001);女性肥胖组甲状腺体积与正常组相比差异有统计学意义(P<0.001)。
                不同代谢综合征组分数量组间相比,甲状腺体积大小的差异有统计学意义(F=10.64,P<0.01)。多元回归分析显示,与甲状腺
                体积相关的指标为性别(β=0.607,95%CI:0.406~0.808,P<0.01)、年龄(β=0.200,95%CI:0.107~0.294,P<0.01)、收缩压(β=
                0.010,95%CI:0.002~0.018,P=0.014)、腰围(β=0.029,95%CI:0.015~0.042,P<0.01)和腰围身高比(β=3.317,95%CI:1.661~
                4.973,P<0.01)。结论:超重、肥胖及代谢综合征组分数量与青少年甲状腺体积相关。
               [关键词] 青少年;甲状腺体积;代谢
               [中图分类号] R581                     [文献标志码] A                       [文章编号] 1007⁃4368(2021)01⁃069⁃05
                doi:10.7655/NYDXBNS20210113



                The association between thyroid volume and metabolic parameters in adolescent
                population in Changzhou
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                XIAO Yang ,XU Shuhang ,GUO Ling ,LÜ Wenjun ,FENG Ningxia ,WANG Qifeng ,MAO Xiaodong ,CHEN
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                Guofang ,HUANG Huaying ,LIU Chao
                1 Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing
                University of Chinese Medicine,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028;
                2 Department of Endocrinology,Chinese Medical Hospital of Wujin,Changzhou 213100,China
               [Abstract] Objective:To explore the association of metabolic parameters and thyroid volume in Chinese adolescents. Methods:A
                total of 1 097 middle school students aged between 12~15 years old(55.6% males)were enrolled. All the participants underwent
                physical examination,biochemical test,and thyroid gland ultrasonography. The thyroid volume of normal,overweight and obese group
                was compared. The association between the number of metabolic syndrome components and thyroid volume was analyzed to study the
                association between metabolic parameters and thyroid volume. Results:In male,the differences of thyroid volume between normal and
                overweight group(P<0.01)or between normal and obesity group(P<0.01)were significant. In female,the difference of thyroid
                volume between normal and obesity group(P<0.01)was significant. Among groups with different number of metabolic syndrome
                components,the difference of thyroid volume was significantly different(F=10.64,P<0.01). According to multiple regression model,
                parameters with significant association with thyroid volume were gender(β=0.607,95%CI:0.406~0.808,P<0.01),age(β=0.200,95%
                CI:0.107~0.294,P<0.01),systolic blood pressure(β=0.010,95%CI:0.002~0.018,P=0.014),waist circumference(β=0.029,95%CI:
                0.015~0.042,P<0.01)and the waist⁃to⁃height ratio(β=3.317,95%CI:1.661~4.973,P<0.01). Conclusion:Overweight,obesity and
                number of components of metabolic syndrome are significantly associated with the volume of thyroid glands in adolescents.
               [Key words] adolescent;thyroid volume;metabolism
                                                                              [J Nanjing Med Univ,2021,41(01):069⁃073]



               [基金项目] 国家重点研发计划(2016YFC1305202);常州市武进区科技项目(WS201617)
                ∗
                通信作者(Corresponding author),E⁃mail:whfhhyfeifan@sina.com;liuchao@nfmcn.com
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