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               ·1452 ·                           南 京    医 科 大 学 学         报                        2021年10月


             [15] CHEN Q Q,ZHANG C,QIN M Q,et al. Inositol⁃requiring  protects the liver from thioacetamide ⁃ induced oxidative
                   enzyme 1 alpha endoribonuclease specific inhibitor STF⁃  stress,inflammation and injury by triggering hepatocyte
                   083010 alleviates carbon tetrachloride induced liver inju⁃  autophagy[J]. Int Immunopharmacol,2019,73:261-269
                   ry and liver fibrosis in mice[J]. Front Pharmacol,2018,  [17] 徐  璐,刘  雷,张  昆,等. STF083010对大鼠肾脏缺
                   9:1344                                            血再灌注损伤的肾保护作用[J]. 中华实用诊断与治疗
             [16] ZHAN F,ZHAO G,LI X,et al. Inositol⁃requiring enzyme  杂志,2017,31(10):955-959
                   1 alpha endoribonuclease specific inhibitor STF⁃083010                 [收稿日期] 2021-02-24




              




             (上接第1439页)                                              2020,78(4):794-800
             [11] HWANG W Y,FU Y,REYON D,et al. Efficient genome  [19] SLAYMAKER I M,GAO L,ZETSCHE B,et al. Rational⁃
                   editing in zebrafish using a CRISPR⁃Cas system[J]. Nat  ly engineered Cas9 nucleases with improved specificity
                   Biotechnol,2013,31(3):227-229                    [J]. Science,2016,351(6268):84-88
             [12] MALI P,YANG L H,ESVELT K M,et al. RNA⁃guided  [20] KLEINSTIVER B P,PATTANAYAK V,PREW M S,et
                   human genome engineering via Cas9[J]. Science,2013,  al. High⁃fidelity CRISPR⁃Cas9 nucleases with no detect⁃
                   339(6121):823-826                                 able genome⁃wide off⁃target effects[J]. Nature,2016,529
             [13] TAN R,DU W,LIU Y,et al. Nucleolus localization of spy⁃  (7587):490-495
                   Cas9 affects its stability and interferes with host protein  [21] CHEN J S,DAGDAS Y S,KLEINSTIVER B P,et al. En⁃
                   translation in mammalian cells[J]. Genes Dis,2020,doi:  hanced proofreading governs CRISPR⁃Cas9 targeting ac⁃
                   10.1016/j.gendis.2020.09.003                      curacy[J]. Nature,2017,550(7676):407-410
             [14] ZHAO L,ZHOU S,GUSTAFSSON J. Nuclear receptors:  [22] HU J H,MILLER S M,GEURTS M H,et al. Evolved Cas9
                   recent drug discovery for cancer therapies[J]. Endocr  variants with broad PAM compatibility and high DNA
                   Rev,2019,40(5):1207-1249                          specificity[J]. Nature,2018,556(7699):57-63
             [15] MARINO M,DISTEFANO E,TRENTALANCE A,et al.     [23] LEE J K,JEONG E,LEE J,et al. Directed evolution of
                   Estradiol ⁃ induced IP(3)mediates the estrogen receptor  CRISPR ⁃ Cas9 to increase its specificity[J]. Nat Com⁃
                   activity expressed in human cells[J]. Mol Cell Endocri⁃  mun,2018,9(1):3048
                   nol,2001,182(1):19-26                        [24] RAN F A,CONG L,YAN W X,et al. In vivo genome edit⁃
             [16] YUSA K,RAD R,TAKEDA J,et al. Generation of trans⁃  ing using Staphylococcus aureus Cas9[J]. Nature,2015,
                   gene⁃free induced pluripotent mouse stem cells by the pig⁃  520(7546):186-191
                   gyBac transposon[J]. Nat Methods,2009,6(5):363-369  [25] ZETSCHE B,GOOTENBERG J S,ABUDAYYEH O O,et
             [17] FU Y F,SANDER J D,REYON D,et al. Improving CRIS⁃   al. Cpf1 is a single RNA⁃guided endonuclease of a class 2
                   PR⁃Cas nuclease specificity using truncated guide RNAs  CRISPR⁃Cas system[J]. Cell,2015,163(3):759-771
                  [J]. Nat Biotechnol,2014,32(3):279-284                                  [收稿日期] 2020-11-13
             [18] SCHMID⁃BURGK J L,GAO L,LI D,et al. Highly paral⁃
                   lel profiling of Cas9 variant specificity[J]. Mol Cell,
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