Page 35 - 第10期

第41卷第10期 南京医科大学学报（自然科学版）
2021年10月 Journal of Nanjing Medical University（Natural Sciences） ·1453 ·

·临床医学·

NGAL 在早发急性 ST 段抬高型心肌梗死患者预后评估中的应

用价值

张 鑫，张喜文 ，谷 阳 *
*
南京医科大学附属淮安第一医院心内科，江苏 淮安 223300

［摘 要］ 目的：研究早发急性 ST 段抬高型心肌梗死（ST⁃segment elevation myocardial infarction，STEMI）的危险因素，探讨血
浆中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase⁃associated lipocalin，NGAL）水平与早发STEMI的相关性及预后评
估价值。方法：选取2017年1月—2018年12月确诊为早发STEMI的患者166例，同期行冠脉造影且血管管腔狭窄<50%的患者
171例作为对照组。随访12个月，探讨早发STEMI患者发生主要不良心血管事件（major adverse cardiac events，MACE）的危险
因素。行受试者工作特征（receiver operating characteristic，ROC）曲线分析，探讨 NGAL 预测患者发生 MACE 的最佳界值。结
果：早发STEMI组的NGAL水平明显高于对照组，差异具有统计学意义（P < 0.05）。早发STEMI患者MACE组的NGAL水平明
显高于无MACE组，差异具有统计学意义（P < 0.05）。Logistic回归结果显示，NGAL水平是早发STEMI患者发生MACE的独立
危险因素（P < 0.05）。ROC曲线分析显示，NGAL预测患者发生MACE的曲线下面积为0.897（P < 0.05）。结论：早发STEMI患
者的NGAL水平明显增高，且与MACE的发生密切相关，对评估早发STEMI患者的预后具有重要的临床应用价值。
［关键词］ 早发急性ST段抬高型心肌梗死；中性粒细胞明胶酶相关脂质运载蛋白；主要不良心血管事件
［中图分类号］ R542.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）10⁃1453⁃05
doi：10.7655/NYDXBNS20211005

The application value of neutrophil gelatinase ⁃ associated lipocalin in the prognosis
assessment among patients with premature ST⁃segment elevation myocardial infarction
* *
ZHANG Xin，ZHANG Xiwen ，GU Yang
Department of Cardiology，the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University，Huai’an
223300，China

［Abstract］ Objective：To study the risk factors of patients with premature ST⁃segment elevation myocardial infarction（STEMI）and
investigate the correlation between neutrophil gelatinase⁃associated lipocalin（NGAL）and premature STEMI and its clinical value in the
prognosis assessment. Methods：Totally 166 patients diagnosed as premature STEMI from Jan 2017 to Dec 2018 were selected and
followed up for 12 months，and 171 patients underwent coronary angiography during the same period with lumen stenosis <50% were
selected as the control group. The risk factors of major adverse cardiac events（MACE）occurrence in premature STEMI patients were
analyzed. Receiver operating characteristic（ROC）curve was used to find the optimal cutoff point for predicting the occurrence of
MACE. Results：NGAL levels were significantly higher in premature STEMI group than those in control group（P < 0.05）. NGAL
levels were significantly higher in MACE group compared with non⁃MACE group（P < 0.05）. Multivariate logistic regression analysis
showed that NGAL was independently associated with MACE occurrence in premature STEMI patients（P < 0.05）. ROC curve of
NGAL in predicting the occurrence of MACE showed that the area under curve of NGAL were 0.897（P < 0.05）. Conclusion：NGAL
levels which were significantly elevated in premature STEMI patients are positively related with MACE occurrence. Thus NGAL can be
used as a predictor of prognosis assessment in premature STEMI patients.
［Key words］ premature ST⁃segment elevation myocardial infarction；neutrophil gelatinase⁃associated lipocalin；major adverse cardiac
event
［J Nanjing Med Univ，2021，41（10）：1453⁃1456，1479］
［基金项目］ 淮安市自然科学研究计划（HAB202025）；南京医科大学附属淮安第一医院科研启动经费资助项目（YGRS202006）
∗
通信作者（Corresponding author），E⁃mail：zhangxiwen303@163.com；guyang1028@163.com