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南京医科大学学报(自然科学版)                                  第41卷第2期
               ·252 ·                     Journal of Nanjing Medical University(Natural Sciences)   2021年2月


             ·影像医学研究·

              基于压缩感知的心脏实时电影技术在评估左心房功能中的价值



              陈 杨,朱晓梅 ,秦 捷,祝因苏,徐 怡
                            *
              南京医科大学第一附属医院放射科,江苏 南京                  210029




             [摘    要] 目的:以传统的分层心脏电影成像(segmented cine imaging)为金标准,评估基于压缩感知(compressed sensing,CS)
              心脏实时电影在评价左心房功能中的价值。方法:纳入健康的志愿者40例和心超提示左心室舒张功能下降的心脏疾病患者
              31例,基于稳态平衡自由进动序列完成分层电影和CS实时电影的左心房数据采集,2名放射科医师独立对图像质量进行定性
              分析,并用CVI42图像后处理软件获得左心房径线、容积和射血分数(ejection fraction,EF),并同步进行定量分析。结果:CS电
              影和传统电影的图像质量无明显差异。两种电影获得左心房径线参数有较好的相关性(ICC>0.90)。除了主动射血分数外,两
              种电影获得的容积及射血分数均有较好的相关性(ICC>0.80)。两种电影获得的左心房二腔心和四腔心横径无明显差异。与
              金标准相比,CS电影高估了左心房最小容积,但是差距较小[(4.45±11.18)mL,P=0.003]。两种方法获得的左心房最大容积、收
              缩前容积和被动射血分数差异无统计学意义。CS电影能较好地区分正常人和左心房功能异常的患者。结论:,CS电影可用来
              准确分析左心房径线和容积,尤其是左心房被动射血分数。
             [关键词] 心脏磁共振;压缩感知;心脏电影;左心房
             [中图分类号] R445                    [文献标志码] A                         [文章编号] 1007⁃4368(2021)02⁃252⁃07
              doi:10.7655/NYDXBNS20210220


              The value of compressed sensing cardiac cine magnetic resonance imaging for analysis

              of left atrial function
                                     *
              CHEN Yang,ZHU Xiaomei ,QIN Jie,ZHU Yinsu,XU Yi
              Department of Radiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China


             [Abstract] Objective:This stndy aims to evaluate the value of compressed sensing(CS)cine cardiac magnetic resonance(CMR)for
              left atrial(LA)functional assessment compared with traditional segmented cine imaging(regarded as gold standard). Methods:Forty
              healthy volunteers and thirty⁃one patients with reduced left ventricular diastolic function by echocardiography underwent segmented
              cine and CS cine imaging with steady⁃state free⁃precession sequence to cover LA during CMR. LA diameter,volume and ejection fraction
             (EF)were evaluated by CVI42(circle cardiovascular imaging,Canada). Two radiologists independently performed qualitative analysis of
              image quality and quantitative analysis of all above LA parameters. Results:The image quality was no significant difference between
              traditional and CS cine. There was an excellent correlation for LA diameter(ICC>0.90)and good correlation for LA volume,EF between
              both cines(ICC>0.80),except for active EF. There were no significant difference in LA 2⁃ and 4⁃chamber transverse diameters derived
              from both cines. Compared to the gold standard,the CS cine overestimated LA minimal volume,but the difference was small[(4.45±
              11.18)mL,P=0.003]. The LA maximal volume,pre ⁃ active volume and passive EF obtained by the two methods had no statistical
              difference. CS cine more accurately distinguished volunteers from patients with abnormal LA function than segmented cine. Conclusion:
              CS cine can be used to accurately evaluate LA diameter and volume for LA functional assessment,especially passive EF of LA.
             [Key words] cardiac magnetic resonance imaging;compressed sensing;cardiac cine MRI;left atrium
                                                                         [J Nanjing Med Univ,2021,41(02):252⁃257,273]




                                                                     生理条件下,左心房功能主要分为储血功能、
             [基金项目] 国家自然科学基金(81701654,81601464)
                                                                导管功能及泵功能,可调节左心室充盈量和维持正
              ∗
              通信作者(Corresponding author),E⁃mail:xiaomeizhu@njmu.edu.
              cn                                                常心搏量,左心房径线和容积在判断多种心血管疾
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