Page 57 - 南京医科大学学报自然科学版

第41卷第2期 南京医科大学学报（自然科学版）
2021年2月 Journal of Nanjing Medical University（Natural Sciences） ·207 ·

·临床研究·

肺高压伴发室上性心律失常危险因素分析

何梦钰，丁怡睿，金琳羚，孔 辉，解卫平 *
南京医科大学第一附属医院呼吸与危重症医学科，江苏 南京 210029

［摘 要］ 目的：研究肺高压（pulmonary hypertension，PH）伴发室上性心律失常（supraventricular arrhythmias，SVA）的危险因
素，提高对 PH 伴发 SVA 的临床认知。方法：回顾性分析 2011 年 1 月—2016 年 12 月南京医科大学第一附属医院住院的 61 例
PH患者临床资料，发现14例伴发SVA。将伴发SVA患者纳入SVA组，未发生SVA患者纳入非SVA组，对PH伴发SVA的危险
因素进行分析。结果：SVA 组共 14 例，男 2 例，女 12 例，年龄（49.21±4.99）岁。非 SVA 组 47 例，男 8 例，女 39 例，年龄（38.02±
1.87）岁。两组比较发现，右心房内径、N末端B型脑利钠肽原（N⁃terminal pro B⁃type natriuretic peptide，NT⁃proBNP）、左心室射
血分数、年龄与PH伴发SVA相关（P < 0.05）。Logistic多因素回归分析示，右心房内径与PH伴发SVA显著相关，右心房内径越
大PH患者发生SVA可能性越大。截至随访结束，SVA组病死率28.57%，中位生存时间为66个月；非SVA组病死率27.66%，中
位生存时间为84个月。结论：右心房内径与PH患者伴发SVA显著相关，是PH患者发生SVA的独立预测因素。
［关键词］ 肺高压；心律失常；心房颤动；右心房扩大

［中图分类号］ R563 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）02⁃207⁃05
doi：10.7655/NYDXBNS20210210

Analysis of risk factors for pulmonary hypertension with supraventricular arrhythmias

HE Mengyu，DING Yirui，JIN Linling，KONG Hui，XIE Weiping *
Department of Respiratory & Critical Care Medicine，the First Affiliated Hospital of Nanjing Medical University，
Nanjing 210029，China

［Abstract］ Objective：To study the risk factors of pulmonary hypertension（PH）with supraventricular arrhythmias（SVA），and to
improve the understanding of PH with SVA. Methods：The clinical data of 61 patients with PH admitted to the First Affiliated Hospital
of NMU from January 2011 to December 2016 were retrospectively analyzed，and SVA was observed in 14 cases. Patients with SVA
were included in the SVA group. Patients without SVA were included in the non⁃SVA group. The risk factors of SVA in PH were
analyzed. Results：There were 14 patients in the SVA group，2 males and 12 females，with an average age of（49.21 ± 4.988）years.
There were 47 patients in the non⁃SVA group，8 males and 39 females，with an average age of（38.02 ± 1.865）years. There were
significant differences in the diameter of right atrium，the N⁃terminal pro B⁃type natriuretic peptide（NT⁃proBNP），ejection fraction of
left ventricular，and age between two groups（P < 0.05）. Multiple factor analysis suggested that the diameter of the right atrium was
significantly related to PH with SVA. At the end of follow⁃up，the mortality rate in the SVA group was 28.57%，and the median survival
time was 66 months；the mortality rate in the non⁃SVA group was 27.66%，and the median survival time was 84 months. Conclusion：
The diameter of right atrium was significantly related to SVA in patients with PH，and was seemed to be an independent predictor of
SVA in patients with PH.
［Key words］ pulmonary hypertension；arrhythmia；atrial fibrillation；right atrium enlargement
［J Nanjing Med Univ，2021，41（02）：207⁃211］

肺高压（pulmonary hypertension，PH）是一类严
［基金项目］ 国家自然科学基金（81273571）；江苏高校优势
学科建设工程资助项目（JX10231802） 重威胁人类健康的肺血管疾病，其主要病理生理学
∗ 特征是静息状态下肺动脉压力升高，同时合并不同
通信作者（Corresponding author），E⁃mail： wpxie@njmu.edu.cn