Page 99 - 南京医科大学学报自然科学版

第41卷第4期 南京医科大学学报（自然科学版）
2021年4月 Journal of Nanjing Medical University（Natural Sciences） ·569 ·

·临床医学·

不同胶原型骨粉应用于拔牙后牙槽骨缺损修复的随机对照研究

陈梦琦 ，景 杨 ，汪家庆 ，王 林 ，李宏卫 1*
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南京医科大学附属口腔医院口腔颌面外科，正畸科，江苏 南京 210029
1 2
［摘 要］ 目的：评价新型胶原型人工骨粉应用于单颗牙拔除后牙槽骨缺损的修复效果。方法：选取就诊于南京医科大学附
属口腔医院口腔颌面外科的89例单颗磨牙需拔除患者，随机分为2组，实验组在拔牙后即刻植入新型胶原型人工骨粉，对照组
植入Bio⁃Oss Collagen，应用可吸收生物膜严密关创。术后当天和术后6个月拍摄锥形束CT（cone beam CT，CBCT），测量相应的
牙槽骨高度、宽度及密度值，进行统计分析；期间3次随访观察创口愈合情况。结果：CBCT测量显示，实验组与对照组牙槽骨
高度和宽度的变化量差异无统计学意义（P > 0.05）；术后 6 个月与术后当天比较，实验组颊侧骨高度及宽度无明显变化，舌
（腭）侧骨高度降低（0.75 ± 0.95）mm，对照组颊侧骨高度降低（0.54 ± 1.47）mm，舌（腭）侧骨高度降低（1.20 ± 1.18）mm，宽度无明
显变化；术后当天实验组骨密度大于对照组（P < 0.01），术后6个月时两组骨密度无明显差异（P > 0.05）。临床检查显示，两组
在创口愈合评分上无明显差异。结论：对于单颗磨牙拔除患者，新型胶原型骨粉在拔牙后牙槽骨缺损修复上与Bio⁃Oss Colla⁃
gen具有相似的作用，并且在颊侧骨高度保存上的效果略优于Bio⁃Oss Collagen。
［关键词］ 胶原型骨粉；Bio⁃Oss Collagen；锥形束CT；骨缺损
［中图分类号］ R782.13 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）04⁃569⁃06
doi：10.7655/NYDXBNS20210416

Application of different collagen⁃type bone graft for the repair of alveolar bone defect after
tooth extraction：a randomized controlled clinical trial

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CHEN Mengqi ，JING Yang ，WANG Jiaqing ，WANG Lin ，LI Hongwei 1*
1 Department of Oral and Maxillofacial Surgery，Department of Orthodontics，the Affiliated Stomatological Hospital of
2
Nanjing Medical University，Nanjing 210029，China
［Abstract］ Objective：To evaluate the effect of a new collagen⁃type artificial bone graft on the repair of alveolar bone defect after
single tooth extraction. Methods：A total of 89 patients with a single molar planned to be extracted at our institution were included and
randomly divided into two groups. The experimental group was implanted with the new collagen⁃type bone graft while the control group
was implanted with Bio⁃Oss collagen immediately after tooth extraction. After then，all wounds were coated by the absorbable biological
membrane. The height，width and density of alveolar bone were tested by CBCT immediately and 6 months after surgery，and clinical
examinations were conducted three times during the period. Results：There was no significant difference in the change of alveolar bone
height and width between the experimental group and the control group（P > 0.05）. In the experimental group，the lingual bone height
decreased by（0.75 ± 0.95）mm，while no significant change was found in the buccal bone height and the width. In the control group，the
height decreased by（0.54 ± 1.47）mm in the buccal and decreased by（1.20 ± 1.18）mm in the lingual，whereas bone width did not
change significantly. Bone density of the experimental group was higher than that of the control group immediately after surgery（P <
0.01），but no significant differences were found between the two groups 6 months after surgery（P > 0.05）. Clinical examination showed
that there was no significant difference in wound healing score between the two groups. Conclusion：The new collagen⁃type artificial
bone graft has similar effects to Bio ⁃ Oss collagen on the repair of alveolar bone defect after extraction，and is slightly better in
preservation of the buccal bone.
［Key words］ collagen⁃type bone graft；Bio⁃Oss collagen；CBCT；bone defect
［J Nanjing Med Univ，2021，41（04）：569⁃574］

［基金项目］ 江苏省医学重点学科（ZCB2012010）
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通信作者（Corresponding author），E⁃mail： lhwqhxa@sina.com