Page 90 - 南京医科大学学报自然科学版
P. 90

第41卷第7期
               ·1020 ·                           南 京    医 科 大 学 学         报                        2021年7月


              症,稳定脑内肥大细胞可能通过HPT轴抑制脂多糖                                引起的 HUVEC 功能异常和凋亡调控作用的研究[J].
              诱导的肝脏炎症。因此,进一步深入研究中枢神经                                 南京医科大学学报(自然科学版),2020,40(11):1590-
              系统肥大细胞激活在肝脏炎症中的作用机制,将为肝                                1596
              脏炎症相关性疾病的预防和治疗提供新的思路。本                            [12] ZHU M,MIAO S,ZHOU W,et al. MAPK,AKT/FoxO3a
                                                                     and mTOR pathways are involved in cadmium regulating
              研究的创新点在于将肝脏炎性的调节与下丘脑中肥
                                                                     the cell cycle,proliferation and apoptosis of chicken follic⁃
              大细胞的激活相联系,中枢神经系统对肝脏炎症的调
                                                                     ular granulosa cells[J]. Ecotoxicol Environ Saf,2021,
              节作用为治疗炎症性肝病拓展了治疗思路。
                                                                     214:112091⁃112101
             [参考文献]                                             [13] NAGATA K,SUZUKI H,SAKAGUCHI S. Common patho⁃
                                                                     genic mechanism in development progression of liver inju⁃
             [1] BLACK P H. Immune system⁃central nervous system in⁃
                                                                     ry caused by non ⁃ alcoholic or alcoholic steatohepatitis
                   teractions:effect and immunomodulatory consequences of
                                                                    [J]. J Toxicol Sci,2007,32(5):453-468
                   immune system mediators on the brain[J]. Antimicrob
                                                                [14] WU H M,NI X X,XU Q Y,et al. Regulation of lipid⁃in⁃
                   Agents Chemother,1994,38(1):7-12
                                                                     duced macrophage polarization through modulating per⁃
             [2] TREFTS E,GANNON M,WASSERMAN D H. The liver
                                                                     oxisome proliferator⁃activated receptor⁃gamma activity af⁃
                  [J]. Curr Biol,2017,27(21):R1147-R1151
                                                                     fects hepatic lipid metabolism via a Toll⁃like receptor 4/
             [3] BRANDT C,NOLTE H,HENSCHKE S,et al. Food per⁃
                                                                     NF ⁃ κB signaling pathway[J]. J Gastroenterol Hepatol,
                   ception primes hepatic ER homeostasis via melanocortin⁃
                                                                     2020,35(11):1998-2008
                   dependent control of mTOR activation[J]. Cell,2018,175
                                                                [15] TAO Y,WANG M,CHEN E,et al. Liver regeneration:
                  (5):1321-1335. e20
                                                                     analysis of the main relevant signaling molecules[J]. Me⁃
             [4] SINHA R A,SINGH B K,YEN P M. Direct effects of thy⁃
                                                                     diators Inflamm,2017,2017:4256352-4256360
                   roid hormones on hepatic lipid metabolism[J]. Nat Rev
                                                                [16] DONG H,WANG Y,ZHANG X,et al. Stabilization of
                   Endocrinol,2018,14(5):259-269
                                                                     brain mast cells alleviates LPS⁃Induced neuroinflamma⁃
             [5] THEOHARIDES T C,STEWART J M,PANAGIOTIDOU
                                                                     tion by inhibiting microglia activation[J]. Front Cell Neu⁃
                   S,et al. Mast cells,brain inflammation and autism[J].
                                                                     rosci,2019,13:191-205
                   Eur J Pharmacol,2016,778:96-102
                                                                [17] 茅江峰,黄炳昆,孙       昭,等. 脂多糖和地塞米松对雄性
             [6] CHO K A,PARK M,KIM Y H,et al. Benzoxazole deriva⁃
                                                                     小鼠下丘脑 Kisspeptin/GPR54 表达的影响[J]. 中华医
                   tives suppress lipopolysaccharide⁃induced mast cell acti⁃
                                                                     学杂志,2016,96(11):897-900
                   vation[J]. Mol Med Rep,2018,17(5):6723-6730
                                                                [18] CORDER R B,FLATLAND B,FRY M M,et al. Cortisol,
             [7] HENDRIKSEN E,VAN BERGEIJK D,OOSTING R S,et
                                                                     progesterone,17α ⁃ hydroxyprogesterone,and TSH re⁃
                   al. Mast cells in neuroinflammation and brain disorders
                                                                     sponses in dogs injected with low⁃dose lipopolysaccharide
                  [J]. Neurosci Biobehav Rev,2017,79:119-133
                                                                    [J]. PeerJ,2019,7:e7468-e7484
             [8] D’MELLO C,SWAIN M G. Liver⁃brain interactions in in⁃
                                                                [19] DE LUCA R,DAVIS P J,LIN H Y,et al. Thyroid hor⁃
                   flammatory liver diseases:implications for fatigue and
                                                                     mones interaction with immune response,inflammation
                   mood disorders[J]. Brain Behav Immun,2014,35:9-20
                                                                     and non⁃thyroidal illness syndrome[J]. Front Cell Dev Bi⁃
             [9] PAXINOS G,WATSON C. The rat brain in stereotaxic co⁃
                                                                     ol,2020,8:614030-614038
                   ordinates[M]. Orlando:Academic Press,Inc,1986:32887
                                                                [20]LI Q,VERMA I M. NF⁃kappaB regulation in the immune
             [10] SKELLY D T,HENNESSY E,DANSEREAU M,et al. A
                                                                     system[J]. Nat Rev Immunol,2002,2(10):725-734
                   systematic analysis of the peripheral and CNS effects of
                                                                [21] GILMORE T D. Introduction to NF⁃kappa B:players,path⁃
                   systemic LPS,IL ⁃ 1B,TNF ⁃ α and IL ⁃ 6 challenges in
                                                                     ways,perspectives[J]. Oncogene,2006,25(51):6680-
                   C57BL/6 mice[J]. PLoS One,2013,8(7):e69123-
                   e69142                                            6684
             [11] 尹超云,潘雅妮,刘        彬,等. 丹参酮ⅡA 磺酸钠对 LPS                                    [收稿日期] 2020-11-31
   85   86   87   88   89   90   91   92   93   94   95