Page 91 - 南京医科大学学报自然科学版

第41卷第7期 南京医科大学学报（自然科学版）
2021年7月 Journal of Nanjing Medical University（Natural Sciences） ·1021 ·

·基础医学·

新型三维打印镁合金支架的显微结构及降解性能研究

汤海燕 ，张 璐 ，陆 韬 ，邱 憬 1*
2
1
2
南京医科大学附属口腔医院种植科，江苏省口腔疾病研究重点实验室，江苏省口腔转化医学工程研究中心，江苏 南京
1
210029；东南大学江苏省先进金属材料高技术研究重点实验室，江苏 南京 211189
2

［摘 要］ 目的：制备一种新型三维打印镁合金支架，探究其显微结构并检测体外降解性能。方法：应用Magics软件设计圆柱
体三维模型，再使用增材制造技术将 AZ91 镁合金粉制备成 3D 打印镁合金（3D⁃AZ91）试件。观察 3D⁃AZ91 与铸造镁合金
（AZ31）试件的金相结构，X射线能量色散光谱仪（energy dispersive X⁃ray spectroscopy，EDX）分析表面元素，X射线衍射仪（（X⁃
ray diffraction，XRD）分析晶相结构，并测试维氏硬度值。采用提拉浸渍法将聚乳酸（polylactic acid，PLA）包裹于3D⁃AZ91表面，
制成复合材料试件（PLA⁃3D⁃AZ91）。进行降解实验，通过析氢观察和计算失重率检测3组试件的体外降解速率。扫描电镜观
察 3D⁃AZ91 和 AZ31 降解后的表面形貌，EDX 分析表面降解产物的元素组成。结果：金相显微镜观察显示 3D⁃AZ91 晶粒较
AZ31更细化，两者表面元素均以Mg为主，晶相以α⁃Mg基体为主。3D⁃AZ91的维氏硬度显著高于AZ31。降解速率3D⁃AZ91＞
AZ31＞PLA⁃3D⁃AZ91，3D⁃AZ91和AZ31表面覆盖不规则团状降解产物，含镁、钙、磷等元素。结论：相比于传统铸造法，3D打
印镁合金的力学性能更佳，而表面包裹PLA能有效控制其降解速率。
［关键词］ 镁合金；三维打印；显微结构；降解性能
［中图分类号］ R783.1 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）07⁃1021⁃07
doi：10.7655/NYDXBNS20210713

The study of microstructure and in vitro degradation performance of a novel 3D⁃printed
magnesium alloy stent

1 2 2 1*
TANG Haiyan ，ZHANG Lu ，LU Tao ，QIU Jing
1 Department of Oral Implantology，the Affiliated Stomatological Hospital of Nanjing Medical University，Jiangsu Key
Laboratory of Oral Diseases，Jiangsu Province Engineering Research Center of Stomatological Translational
2
Medicine，Nanjing 210029；Jiangsu Key Laboratory for Advanced Metallic Materials，Southeast University，Nanjing
211189，China

［Abstract］ Objective：To prepare a novel magnesium alloy stent using 3D printing and investigate its microstructure and in vitro
degradation performance. Methods：Magics software was applied to design a cylinder 3D model，on the basis of which，3D⁃printed
magnesium alloy（3D⁃AZ91）specimens were prepared with AZ91 magnesium alloy powder via an additive manufacturing technology.
Then，metallographic structures of 3D⁃AZ91 and casting magnesium alloy（AZ31）specimens were observed. Surface elements and
crystal phase structure were analyzed by EDX and XRD，respectively. Vickers hardness values were tested. After that，the polylactic
acid（PLA）was coated on the surface of 3D ⁃ AZ91 to make the composite material specimen（PLA ⁃ 3D ⁃ AZ91）. The degradation
experiment was performed，and the in vitro degradation properties of three different specimens were measured by observing hydrogen
evolution and calculating weight loss rate. The surface morphology of 3D⁃AZ91 and AZ31 specimens after degradation was evaluated
by the scanning electron microscopy. The elemental compositions of the surface degradation products were examined by EDX. Results：
Metallographic observation showed more obvious grain refinement in 3D⁃AZ91 than in AZ31. Mg was main surface element and α⁃Mg
matrix was main crystal phase for both of them. The Vickers hardness of 3D⁃AZ91 was significantly higher than that of AZ31. The
［基金项目］ 国家自然科学基金面上项目（81870799）；江苏省重点研发计划（社会发展）项目（BE2019728）；东南大学⁃南京医
科大学合作基金面上项目（2242017K3DN14）；镇江市重点研发计划（社会发展）项目（SH2019040）；江苏高校优势学科建设工
程资助项目（2018⁃87）
∗
通信作者（Corresponding author），E⁃mail：qiujing@njmu.edu.cn