Page 47 - 南京医科大学学报自然科学版

第41卷第8期 方 萌，池晴佳，赵 晗，等. SOX12与肝细胞癌患者不良预后和免疫浸润的相关性研究［J］.
2021年8月 南京医科大学学报（自然科学版），2021，41（08）：1141-1150，1165 ·1149 ·

A B
Aitered in 150（89.82%）of 167 samples. Aitered in 160（73.73%）of 217 samples.
1 293 815

0 67 0 54
0 0
TP53 40% TP53 25%
TTN 29% TTN 24%
CTNNB1 24% CTNNB1 17%
MUC16 16% MUC16 12%
OBSCN 15% ALB 8%
ALB 12% OBSCN 8%
LRP1B 12% CSMD3 8%
PCLO 11% APOB 7%
ABCA13 11% CACNA1E 7%
APOB 11% FAT3 7%
CACNA1E 11% LRP1B 7%
FLG 10% PCLO 7%
FAT3 10% RYR2 7%
RYR2 10% CSMD3 6%
CSMD3 9% USH2A 6%
GPR98 9% ABCA13 6%
RB1 9% XIRP2 6%
DNAH7 8% DNAH7 6%
DOCK2 8% PKHD1L1 6%
WDR87 8% RYR3 6%
Missense_Mutation Frame_Shift_Ins Missense_Mutation Splice_Site
Splice_Site In_Frame_Del Splice_Site_Del Frame_Shift_Ins
Frame Shift Del In Frame Ins Nonsense Mutation In Frame Ins
C D
Aitered in 155（91.18%）of 170 samples. Aitered in 132（83.54%）of 158 samples.
1 293 1 049

0 68 0 44
0 0
TP53 40% CTNNB1 28%
TTN 32% TTN 23%
CTNNB1 25% TP53 20%
MUC16 19% MUC16 13%
OBSCN 12% PCLO 13%
FLG 12% ALB 13%
ALB 11% APOB 11%
FAT3 11% ABCA13 10%
LRP1B 11% OBSCN 9%
PCLO 10% PRKDC 9%
RYR2 10% HMCN1 8%
ABCA13 9% LRP1B 8%
ARID1A 9% RYR2 8%
CSMD3 9% XIRP2 8%
AXOM1 9% CACNA1E 8%
CACNA1E 9% CSMD1 8%
GPR98 9% CSMD3 8%
UNC80 9% HERC2 8%
APOB 8% RYR1 8%
DNAH7 8% BIRC6 7%
Missense_Mutation In_Frame_Del Missense_Mutation Frame_Shift_Ins
Splice_Site Frame_Shift_Ins Frame_Shift_Del Splice_Site
Frame Shift Del In Frame Ins Nonsense Mutation In Frame Ins
A：高SOX12表达组；B：低SOX12表达组；C：IRG高风险组；D：IRG低风险组。
图9 HCC中基因突变的瀑布图
Figure 9 Waterfall chart of genetic mutations in HCC

开展提供参考。 ［3］ ZAWERTON A，YAO B，YEAGER J P，et al. De novo

SOX4 variants cause a neurodevelopmental disease asso⁃
［参考文献］
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pressed in chondrogenesis and cooperatively activate the
［2］ HUANG X，WU C，GONG K，et al. Sox gene family re⁃ type II collagen gene［J］. EMBO J，17（19）：5718-5733
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