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第42卷第7期 祁颜艳,顾 愹,杨 涛. 负载HIP的耐受性树突状细胞对BDC2.5 T细胞的免疫调节作用[J].
2022年7月 南京医科大学学报(自然科学版),2022,42(7):913-920 ·919 ·
iDC LPS⁃iDC tolDC LPS⁃tolDC
10 5 0% 7.60% 10 5 0.009% 4.05% 10 5 0.55% 9.96% 10 5 0.068% 7.40%
10 4 10 4 10 4 10 4
2.5HIP组 10 3 2 10 3 2 10 3 2 10 3 2
10
10
10
10
101 101 101 101
14.0% 78.4% 6.96% 89.0% 54.9% 34.6% 37.7% 54.8%
1
1
1
1
10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4
10 5 4 0.17% 7.60% 10 5 4 0.022% 0.45% 10 5 4 0.77% 1.16% 10 5 4 4.82% 0.56%
10
10
10
无关肽组 10 3 2 10 3 2 10 3 2 10 3 2
10
10
10
10
10
101 101 101 101
82.5% 78.4% 87.6% 12.0% 95.7% 2.32% 96.7% 0.97%
1
1
1
1
10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4 10 0 10 10 2 10 3 10 4
( % ) 15 *** □ 无关肽组
■ 2.5HIP组
CD4 + CD25 + Foxp3 + 10 5
0
LPS⁃tolDC
iDC LPS⁃iDC tolDC
诱导Treg生成的情况(CD4 T细胞中CD25 Foxp3 所占比例)。两组比较, P < 0.001,n:3~4。
+
+
+
***
+
图4 BDC2.5 CD4 T细胞与负载2.5HIP的DC共培养后产生Treg的比例
Figure 4 Proportion of Treg in BDC2.5 CD4 T cells co⁃cultured with 2.5HIP⁃loaded DC
+
的增殖活化,诱导抗原特异性 Treg 的产生,这为今 sights,biomarkers and therapeutic targets[J]. Front Im⁃
后 T1DM 的抗原特异性细胞疗法提供了参考,但对 munol,2021,12:667989
于T1DM的具体治疗效果还需要更进一步的探究。 [6] BALAKRISHNAN S,KUMAR P,PRABHAKAR B S. Post⁃
translational modifications contribute to neoepitopes in
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