Page 19 - 南京医科大学学报自然科学版
P. 19
第43卷第12期 黄凯玥,张 伟,朱玉婕,等. 氯氮平对斑马鱼心脏发育的影响及机制研究[J].
2023年12月 南京医科大学学报(自然科学版),2023,43(12):1630-1635 ·1635 ·
激的主要原因。溴隐亭是一种多巴胺 D2 受体激动 2020,23(3):441-445
剂,作为围产期心肌病治疗药物,具有高效和安全 [12] ZHANG F,HAN L,WANG J,et al. Clozapine induced de⁃
性 [24] 。溴隐亭处理后相较于H⁃CLP组,内质网应激 velopmental and cardiac toxicity on zebrafish embryos by
elevating oxidative stress[J]. Cardiovasc Toxicol,2021,
标志基因显著下调,斑马鱼心包水肿、心率过缓,心脏
21(5):399-409
环化均得到缓解。以上提示,氯氮平引起胚胎发育的
[13] REN J,BI Y,SOWERS J R,et al. Endoplasmic reticulum
心脏损伤,可能是其多巴胺D2受体的毒性作用所致。
stress and unfolded protein response in cardiovascular dis⁃
综上所述,氯氮平可能因其抑制多巴胺 D2 受 eases[J]. Nat Rev Cardiol,2021,18(7):499-521
体,导致胚胎出现内质网应激,引起了细胞凋亡,最 [14] RUAN Y,ZENG J,JIN Q,et al. Endoplasmic reticulum
终造成了斑马鱼心脏发育损伤。 stress serves an important role in cardiac ischemia/reper⁃
fusion injury(Review)[J]. Exp Ther Med,2020,20(6):
[参考文献]
268-279
[1] BOYD R,MCMULLEN H,BEQAJ H,et al. Environmen⁃ [15] 史有阳,郝 炜,吴春宇,等. 斑马鱼心脏损伤模型的建
tal exposures and congenital heart disease[J]. Pediatrics, 立及桔梗提取物对其心脏损伤的干预作用研究[J]. 江
2022,149(1):e2021052151
苏中医药,2020,52(5):82-85
[2] MA X J,HUANG G Y. Current status of screening,diag⁃ [16] BHAGAT J,ZANG L,NISHIMURA N,et al. Zebrafish:
nosis,and treatment of neonatal congenital heart disease
an emerging model to study microplastic and nanoplastic
in China[J]. World J Pediatr,2018,14(4):313-314
toxicity[J]. Sci Total Environ,2020,728:138707
[3] ANDERSON K N,LIND J N,SIMEONE R M,et al. Mater⁃
[17] BOWLEY G,KUGLER E,WILKINSON R,et al. Zebraf⁃
nal use of specific antidepressant medications during ear⁃
ish as a tractable model of human cardiovascular disease
ly pregnancy and the risk of selected birth defects[J]. JA⁃
[J]. Br J Pharmacol,2022,179(5):900-917
MA Psychiatry,2020,77(12):1246-1255
[18] DRAKHLIS L,BISWANATH S,FARR C M,et al. Hu⁃
[4] 房 宁,陈丽娟,范光磊,等. 24节段二维斑点追踪技术 man heart⁃forming organoids recapitulate early heart and
评估妊娠期糖尿病胎儿心室收缩功能的研究[J]. 南京 foregut development[J]. Nat Biotechnol,2021,39(6):
医科大学学报(自然科学版),2022,42(5):708-714 737-746
[5] 徐 影,刁飞扬. 母体微生物群对妊娠并发症及子代发 [19] TAN C M J,LEWANDOWSKI A J. The transitional heart:
育的影响[J]. 南京医科大学学报(自然科学版)2022, from early embryonic and fetal development to neonatal
42(7):1030-1035 life[J]. Fetal Diagn Ther,2020,47(5):373-386
[6] SEEMAN P. Clozapine,a fast ⁃ off ⁃ D2 antipsychotic[J]. [20] KNUTSON A K,WILLIAMS A L,BOISVERT W A,et al.
ACS Chem Neurosci,2014,5(1):24-29 HIF in the heart:development,metabolism,ischemia,and
[7] ICHIKAWA J,DAI J,MELTZER H Y. DOI,a 5⁃HT2A/ atherosclerosis[J]. J Clin Invest,2021,131(17):
2C receptor agonist,attenuates clozapine⁃induced cortical e137557
dopamine release[J]. Brain Res,2001,907(1⁃2):151- [21] HU H,TIAN M,DING C,et al. The C/EBP homologous
155 protein(CHOP)transcription factor functions in endoplas⁃
[8] VICKERS M,RAMINENI V,MALACOVA E,et al. Risk mic reticulum stress⁃induced apoptosis and microbial in⁃
factors for clozapine⁃induced myocarditis and cardiomyop⁃ fection[J]. Front Immunol,2018,9:3083
athy:A systematic review and meta⁃analysis[J]. Acta Psy⁃ [22] FU X,CUI J,MENG X,et al. Endoplasmic reticulum
chiatr Scand,2022,145(5):442-455 stress,cell death and tumor:Association between endo⁃
[9] HÁLFDÁNARSON Ó,COHEN J M,KARLSTAD Ø,et al. plasmic reticulum stress and the apoptosis pathway in tu⁃
Antipsychotic use in pregnancy and risk of attention/defi⁃ mors(Review)[J]. Oncol Rep,2021,45(3):801-808
cit⁃hyperactivity disorder and autism spectrum disorder:a [23] LUO X,O'NEILL K L,HUANG K. The third model of
Nordic cohort study[J]. Evid Based Ment Health,2022, Bax/Bak activation:a Bcl⁃2 family feud finally resolved?
25(2):54-62 [J].F1000Res,2020,9:935
[10] MEHTA T M,VAN LIESHOUT R J. A review of the safe⁃ [24] TRONGTORSAK A,KITTIPIBUL V,MAHABIR S,et al.
ty of clozapine during pregnancy and lactation[J]. Arch Effects of bromocriptine in peripartum cardiomyopathy:a
Womens Ment Health,2017,20(1):1-9 systematic review and meta⁃analysis[J]. Heart Fail Rev,
[11] NGUYEN T,MORDECAI J,WATT F,et al. Obstetric and 2022,27(2):533-543
neonatal outcomes of clozapine exposure in pregnancy:a [收稿日期] 2023-03-30
consecutive case series[J]. Arch Womens Ment Health, (本文编辑:唐 震)