Page 39 - 南京医科大学学报自然科学版
P. 39
第43卷第12期 王 瑶,张劲松,范博文,等. 急性硫化氢中毒合并中枢神经系统损伤的相关危险因素及其预测
2023年12月 价值研究[J]. 南京医科大学学报(自然科学版),2023,43(12):1650-1655,1680 ·1655 ·
存在于神经元及神经内分泌组织中。研究显示NSE Med,1999,35(2):192-195
改变与神经系统疾病关系密切,被认为是神经元损 [9] WANG J,ZHANG H,SU C,et al. Dexamethasone amelio⁃
伤的生物标志物。研究表明在心肺复苏术后合并 rates H(2)S⁃induced acute lung injury by alleviating ma⁃
弥漫性脑水肿、急性缺血性脑卒中、自发性或创伤 trix metalloproteinase ⁃ 2 and ⁃ 9 expression[J]. PLoS
One,2014,9(4):e94701
性脑出血、颅内感染等患者中均发现血清NSE水平
[10] HAOUZI P,SONOBE T,JUDENHERC⁃HAOUZI A. Hy⁃
增高,且与病情严重程度及早期不良预后有显著相
drogen sulfide intoxication induced brain injury and meth⁃
关性 [19-24,26] 。本研究也同样发现急性 H2S 中毒合并
ylene blue[J]. Neurobiol Dis,2020,133:104474
CNS 损伤患者血清 NSE 明显升高,是其独立危险因 [11] TANG D,TIAN N,CAI J,et al. Analysis of CT and MR
素之一。并且同时与血清 Lac 联合分析后,AUC 达 imaging features of the brain in patients with hydrogen
0.948,显著高于单个指标的预测效能。因此本研究 sulfide poisoning based on clinical symptom grading[J].
认为 NSE 联合 Lac 对急性 H2S 中毒合并 CNS 损伤具 BMC Neurol,2022,22(1):413
有良好的临床预测价值。 [12] 宋丽红,于军红,胡晓亮,等. 疑似急性硫化氢中毒迟发
综上所述,与未合并 CNS 损伤的急性 H2S 中毒 性脑病 1 例[J]. 中华劳动卫生职业病杂志,2022,40
(7):529-531
患者相比,合并 CNS 损伤患者并发 ARDS 及心肌损
[13]王涤新,王淑芬,刘维群,等. 急性硫化氢中毒152例临
害的风险升高,30 d 的致残及死亡率明显增加;此
床分析[J]. 中华预防医学杂志,1989,23(6):330-332
外,急性H2S中毒联合早期血清Lac以及NSE水平升 [14] SHEIKH S,BAIG M A,ALI N,et al. Hydrogen sulfide gas
高判断急性H2S中毒合并CNS损伤具有较高的临床 poisoning in fish garbage room:a report of a fisherman
价值,以便临床医生早期诊断、早期治疗。 [J]. J Pak Med Assoc,2017,67(7):1097-1099
[参考文献] [15] SUZUKI Y,TAGUCHI K,OKAMOTO W,et al. Methemo⁃
globin⁃albumin clusters for the treatment of hydrogen sul⁃
[1] SANTANA M C,WEIR A,RUMBEIHA W K. A compre⁃
fide intoxication[J]. J Control Release,2022,349:304-314
hensive review of treatments for hydrogen sulfide poison⁃
[16] BAUD F J,HAIDAR M K,JOUFFROY R,et al. Determi⁃
ing:past,present,and future[J]. Toxicol Mech Methods,
nants of lactic acidosis in acute cyanide poisonings[J].
2023,33(3):183-196
Crit Care Med,2018,46(6):e523-e529
[2] SANTANA MALDONADO C M,KIM D S,PURNELL B,
[17] ANANTHARAM P,WHITLEY E M,MAHAMA B,et al.
et al. Acute hydrogen sulfide⁃induced neurochemical and
Characterizing a mouse model for evaluation of counter⁃
morphological changes in the brainstem[J]. Toxicology,
measures against hydrogen sulfide⁃induced neurotoxicity
2023,485:153424 and neurological sequelae[J]. Ann N Y Acad Sci,2017,
[3] NG P C,HENDRY⁃HOFER T B,WITEOF A E,et al. Hy⁃
1400(1):46-64
drogen sulfide toxicity:mechanism of action,clinical pre⁃ [18] WARENYCIA M W,SMITH K A,BLASHKO C S,et al.
sentation,and countermeasure development[J]. J Med Monoamine oxidase inhibition as a sequel of hydrogen sul⁃
Toxicol,2019,15(4):287-294 fide intoxication:increases in brain catecholamine and 5⁃
[4] JIANG J,CHAN A,ALI S,et al. Hydrogen sulfide⁃mecha⁃ hydroxytryptamine levels[J]. Arch Toxicol,1989,63(2):
nisms of toxicity and development of an antidote[J]. Sci
131-136
Rep,2016,6:20831 [19] FREEMAN W D,CHIOTA N A. Neuron⁃specific enolase
[5] MO W,SHEN J,HUANG X,et al. Acute myocardial inju⁃ correlates with other prognostic markers after cardiac ar⁃
ry following hydrogen sulfide poisoning[J]. Toxicol Ind rest[J]. Neurology,2011,77(20):1856-1857
Health,2020,36(10):750-758 [20] SHARMA K,JOHN M,ZHANG S,et al. Serum neuron⁃
[6] MIYAZAKI Y,MARUTANI E,IKEDA T,et al. A sulfonyl specific enolase thresholds for predicting postcardiac ar⁃
azide⁃based sulfide scavenger rescues mice from lethal hy⁃ rest outcome:a systematic review and meta⁃analysis[J].
drogen sulfide intoxication[J]. Toxicol Sci,2021,183 Neurology,2022,98(1):62-72
(2):393-403 [21] ZHANG P,OMANSKA A,ANDER B P,et al. Neuron⁃spe⁃
[7] KHATTAK S,ZHANG Q Q,SARFRAZ M,et al. The role cific transcriptomic signatures indicate neuroinflamma⁃
of hydrogen sulfide in respiratory diseases[J]. Biomole⁃ tion and altered neuronal activity in ASD temporal cortex
cules,2021,11(5):682 [J]. Proc Natl Acad Sci U S A,2023,120(10):
[8] MILBY T H,BASELT R C. Hydrogen sulfide poisoning: e2088209176
clarification of some controversial issues[J]. Am J Ind (下转第1680页)