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第43卷第12期          辅  容,陆 辉,杭 菁,等. 645例初治甲状腺乳头状癌患者气管周围淋巴结转移的危险
                 2023年12月               因素分析[J]. 南京医科大学学报(自然科学版),2023,43(12):1681-1685                  ·1685 ·


                管周围淋巴结转移的独立危险因素。因此,若能在                           [4] LIU C,XIAO C,CHEN J,et al. Risk factor analysis for
                术中对喉前淋巴结进行冰冻病理分析,其结果对是                                 predicting cervical lymph node metastasis in papillary thy⁃
                否行气管周围淋巴结清扫有指导意义。本研究表                                  roid carcinoma:a study of 966 patients[J]. BMC Cancer,
                明,喉前淋巴结转移对气管周围淋巴结转移的灵敏                                 2019,19(1):622
                                                                 [5] 中华医学会内分泌学分会,中华医学会外科学分会,中
                度、特异度、阳性预测值、阴性预测值和准确度分别
                                                                       国抗癌协会头颈肿瘤专业委员会,等. 甲状腺结节和分
                为 21.4%、93.7%、63.0%、70.5%、69.6%,特异度、阴                  化型甲状腺癌指南[J]. 中华核医学与分子影像杂志,
                性预测值和准确度较高。对 T1/2 期进行亚组分析                              2013,33(2):96-115
                提示,喉前淋巴结转移对气管周围淋巴结转移的灵                           [6] HAUGEN B R. 2015 American thyroid association man⁃
                敏度、特异度、阳性预测值、阴性预测值和准确度分                                agement guidelines for adult patients with thyroid nodules
                别为 21.3%、93.5%、58.8%、73.0%、71.4%,阴性预测                  and differentiated thyroid cancer:what is new and what
                值和准确度更高,说明排他性更强,可用于排除性                                 has changed?[J]. Cancer,2017,123(3):372-381
                                                                 [7] LI Y,GAO X,GUO T,et al. Development and validation
                诊断。气管周围淋巴结清扫会加剧下位甲状旁腺
                                                                       of nomograms for predicting the risk of central lymph
                血供破坏风险和严重程度,增加甲状旁腺功能低下
                                                                       node metastasis of solitary papillary thyroid carcinoma of
                可能。因此,综合患者情况和癌灶位置等特征,喉                                 the isthmus[J]. J Cancer Res Clin Oncol,2023,149(16):
                前淋巴结转移对气管周围淋巴结受累有一定预测                                  14853-14868
                性。评估喉前淋巴结有助于制定气管周围淋巴结                            [8] ISAACS J D,LUNDGREN C I,SIDHU S B,et al. The del⁃
                处理策略,若喉前淋巴结未转移,是否需进行下一步                                phian lymph node in thyroid cancer[J]. Ann Surg,2008,
                中央区其他区域淋巴结清扫值得探讨,但目前仍需要                                247(3):477-482
                更多循证医学证据以帮助临床医生更好地决策。                            [9] SANTRAC N,BESIC N,BUTA M,et al. Lymphatic drain⁃
                                                                       age,regional metastases and surgical management of pap⁃
               [参考文献]
                                                                       illary thyroid carcinoma arising in pyramidal lobe⁃a single
               [1] HENG Y,YANG Z,ZHOU L,et al. Risk stratification for  institution experience[J]. Endocr J,2014,61(1):55-59
                    lateral involvement in papillary thyroid carcinoma pa⁃  [10] IYER N G,KUMAR A,NIXON I J,et al. Incidence and
                    tients with central lymph node metastasis[J]. Endocrine,  significance of Delphian node metastasis in papillary thy⁃
                    2020,68(2):320-328                                 roid cancer[J]. Ann Surg,2011,253(5):988-991
               [2] FENG J W,YANG X H,WU B Q,et al. Predictive factors  [11] ISAACS J D,MCMULLEN T P,SIDHU S B,et al. Predic⁃
                    for central lymph node and lateral cervical lymph node  tive value of the Delphian and level VI nodes in papillary
                    metastases in papillary thyroid carcinoma[J]. Clin Transl  thyroid cancer[J]. ANZ J Surg 2010,80(11):834-838
                    Oncol,2019,21(11):1482-1491                  [12] YAN Y,WANG Y,LIU N,et al. Predictive value of the
               [3] YANG Z,HENG Y,ZHOU J,et al. Central and lateral     Delphian lymph node in cervical lymph node metastasis
                    neck involvement in papillary thyroid carcinoma patients  of papillary thyroid carcinoma[J]. Eur J Surg Oncol,
                    with or without thyroid capsular invasion:a multi ⁃ center  2021,47(7):1727-1733
                    analysis[J]. Front Endocrinol(Lausanne),2023,14:                        [收稿日期] 2023-08-17
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