Page 80 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第44卷第10期
·1396 · Journal of Nanjing Medical University（Natural Sciences） 2024年10月

·临床研究·

妊娠对肺部磨玻璃结节生长的影响

王博煊，徐 海，许晓泉，仲 艳，陆 杰，高叶祺，俞同福 *
南京医科大学第一附属医院放射科，江苏 南京 210029

［摘 要］ 目的：通过单中心回顾性队列评估妊娠与磨玻璃结节生长之间的关系。方法：回顾性分析44例因肺部磨玻璃结节
行孕前和分娩后胸部CT扫描的妊娠孕妇的临床和影像学资料。根据影像学特征，将磨玻璃结节分为纯磨玻璃结节、异质性磨
玻璃结节和部分实性结节。磨玻璃结节的大小定义为胸部CT扫描轴位图像中的最大直径，而观察间隔定义为孕前和分娩后
胸部CT检查之间的时间间隔。当磨玻璃结节最大直径增加2 mm、固体成分增加2 mm或出现新的固体成分时，则被认为磨玻
璃结节出现了生长。结果：在44例中，共检出70个磨玻璃结节，其中包括66个纯磨玻璃结节和4个异质性磨玻璃结节。其中
43个磨玻璃结节直径<6 mm，22个直径6.0~7.9 mm，4个直径8.0~9.9 mm，1个直径≥10 mm。在779 d的中位观察间隔（范围为
337~2 795 d）内，未观察到磨玻璃结节出现生长。结论：妊娠不太可能导致肺部直径较小的纯磨玻璃结节生长。因此，育龄期
女性患者如有怀孕计划，无需过度担心此类纯磨玻璃结节的生长问题。
［关键词］ 磨玻璃结节；生长；妊娠
［中图分类号］ R814.42 ［文献标志码］ A ［文章编号］ 1007⁃4368（2024）10⁃1396⁃05
doi：10.7655/NYDXBNSN240812

Influence of pregnancy on the growth of pulmonary ground glass nodules

WANG Boxuan，XU Hai，XU Xiaoquan，ZHONG Yan，LU Jie，GAO Yeqi，YU Tongfu *
Department of Radiology，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：To evaluate the relationship between pregnancy and the growth of ground glass nodules（GGNs）through a
single⁃center retrospective cohort analysis. Methods：Clinical and radiologic data of 44 pregnant women who underwent pre⁃ and post⁃
pregnancy chest CT scans due to pulmonary GGNs were retrospectively reviewed. Based on imaging characteristics，the GGNs were
divided into the pure GGNs（PGGNs），heterogeneous GGNs（HGGNs），and part solid nodules（PSN）. The size of a GGN was
determined as the maximum diameter in axial chest CT images，and the observation interval was the time between pre⁃ and post⁃
pregnancy chest CT scans. Growth of a GGN was defined as an increase of 2 mm in the maximum diameter，an increase of 2 mm in the
solid composnent，or the appearance of new solid component. Results：Among the 44 pregnant women，70 GGNs were detected，
including 66 PGGNs and 4 HGGNs. Of these，43 GGNs had a diameter of < 6 mm，22 were between 6.0 and 7.9 mm，4 were between
8.0 and 9.9 mm，and 1 GGN was ≥10 mm. No growth of pulmonary GGNs was observed at a median observing interval of 779 days
（ranging from 337 to 2 795 days）. Conclusion：Pregnancy is unlikely to cause the growth of pulmonary PGGNs with a small diameter.
Therefore，women of child⁃bearing age who plan to become pregnant need not be overly concerned about the growth of such GGNs.
［Key words］ ground glass nodule；growth；pregnancy
［J Nanjing Med Univ，2024，44（10）：1396⁃1400］

近年来，随着肺癌低剂量 CT 筛查的推广，肺部 著增加。GGN被定义为CT肺窗图像中可观察到的
磨玻璃结节（ground glass nodules，GGN）的检出率显 圆形或类圆形高密度病变，不掩盖其内走行的血管
和支气管影，呈现出磨玻璃样的特征 。尽管随访
［1］
［基金项目］ 江苏省卫生健康委员会科研重点项目（K2023057） 时持续存在的GGN具有较高的肿瘤风险，但它也可
∗ 能是由肉芽肿、肺泡出血或间质纤维化等疾病引起
通信作者（Corresponding author），E⁃mail：yu.tongfu @163.com