Page 63 - 南京医科大学自然版
P. 63

第44卷第11期         陈   思,陈允安,张 洁,等. 多模态影像对STEMI患者急诊PCI术后MACE的预测价值[J].
                 2024年11月                  南京医科大学学报(自然科学版),2024,44(11):1525-1533,1549                   ·1529 ·


                                                     表1 两组患者临床特征比较
                                Table 1 Comparison of clinical characteristics between the two groups of patients

                            Demographics                  MACE(+)(n=20)          MACE(-)(n=70)            P
                   Age(years,x ± s)                          62.0 ± 9.2            057.1 ± 10.6         0.063
                   Male[n(%)]                                17(85.0)               55(78.6)%           0.751
                   Hypertension[n(%)]                        09(45.0)               35(50.0)%           0.693
                   Diabetes[n(%)]                            07(35.0)               28(40.0)%           0.686
                   Hyperlipidemia[n(%)]                      09(45.0)               32(45.7)%           0.955
                   LAD is IRA[n(%)]                          15(75.0)               29(41.4)%           0.008
                   Degree of stenosisof the IRA(%,x ± s)     92.9 ± 6.1             90.6 ± 6.0          0.138
                   Lengths of thestent(mm,x ± s)            048.0 ± 13.3           041.5 ± 14.3         0.077
                   GRACE score>140[n(%)]                     17(85.0)               41(58.6)%           0.056
                   Extensive myocardial infarction[n(%)]     19(95.0)               44(62.9)%           0.013
                   Peak hs⁃cTnI(pg/mL,x ± s)              23 418.8 ± 7 648.0     21 818.3 ± 7 052.1     0.382
                   Peak NT⁃proBNP(pg/mL,x ± s)            1 296.9 ± 230.5         1 058.3 ± 450.4       0.002
                   Peak CRP(mg/L,x ± s)                     023.5 ± 11.9            14.7 ± 5.0          0.004
                   Peak CK(U/L,x ± s)                     03 193.5 ± 2 296.0     02 126.3 ± 1 528.5     0.017
                   Aspirin[n(%)]                            020(100.0)              66(94.3)0           0.572
                   Ticagrelor[n(%)]                          19(95.0)               69(98.6)0           0.924
                   Statins[n(%)]                             19(95.0)               69(98.6)0           0.924
                   B⁃receptor blocker[n(%)]                 020(100.0)              58(82.9)0           0.061
                   ARNI[n(%)]                                17(85.0)               57(81.4)0           0.971
                   LAD:left anterior descending branch;IRA:infarction related artery;hs⁃cTnI:high sensitivity troponinI;CK:creatine kinase;ARNI:inhibitors of
                angiotensin receptor enkephalinase;MACE:major adverse cardiovascular events.

                                                  表2 两组患者基线影像学参数比较
                              Table 2 Comparison of baselineimaging parameters betweenthe two groups ofpatients  (x ± s)
                                  MACE(+)     MACE(-)                               MACE(+)     MACE(-)
                     Variable                              P           Variable                             P
                                  (n=20)      (n=70)                                (n=20)      (n=70)
                TTE                                               MW(mmHg%)
                  TTE⁃LVEF(%)     44.1 ± 5.6  50.2 ± 6.3  <0.001    GWI           1 113.3 ± 99.20 1 322.5 ± 186.6 <0.001
                  TTE⁃LVEDV(mL) 130.6 ± 15.0  123.4 ± 13.3  0.049   GCW           1 332.7 ± 600.3 1 699.8 ± 447.6  0.004
                  TTE⁃LVESV(mL) 0 67.8 ± 11.8  0 61.8 ± 12.3  0.057  GWW          0 330.4 ± 362.0 174.2 ± 97.4  0.002
                3D⁃STE(%)                                           GWE            0 80.8 ± 10.3  87.9 ± 6.1  <0.001
                  GLS             -9.8 ± 0.7  -11.6 ± 1.6  <0.001  LGE⁃CMR
                  GCS             -9.4 ± 2.1  -11.5 ± 2.6  0.001    IS(%)           30.4 ± 5.3  21.9 ± 4.9  <0.001
                  GAS            -14.9 ± 2.8  -20.2 ± 4.9  <0.001   CMR⁃LVEDV(mL) 150.9 ± 9.0  149.9 ± 9.7  0.702
                  GRS             20.3 ± 4.6  26.5 ± 7.0  <0.001    CMR⁃LVESV(mL) 82.2 ± 9.2    77.6 ± 9.5  0.063
                                                                    CMR⁃LVEF(%)     45.3 ± 3.7  48.2 ± 4.8  0.015
                   GLS:global longitudinal strain;GCS:global circumferential strain;GAS:global area strain;GRS:global radial strain;MW:myocardial work;GWI:
                global work index;GCW:global constructive work;GWW:global wasted work;GWE:global work efficiency;LGE⁃CMR:late gadolinium enhancement
                imaging⁃cardiac magnetic resonance;IS:infarctionsize;LVEDV:left ventricular end diastolic volume;LVESV:left ventricular end systolic volume;
                LVEF:left ventricular ejection fraction.

                灵敏度为 100%,特异度 58.6%,GLS 和 GWI 联合预                 GWI 0.830;GWI 0.830 vs. IS 0.886,GLS+GWI 0.939
                测MACE发生的AUC值达0.939,灵敏度为85%,特异                     vs. IS 0.886,P 均>0.05)。而 GLS+GWI 联合预测
                度为90%(图3,表4)。使用DeLong方法比较AUC值                     MACE 发生的价值显著优于 GLS 和 GWI 单一指标

                无显著差异(GLS 0.846 vs. IS 0.886;GLS 0.846 vs.       (P均<0.05)。GLS、GWI、IS预测MACE的ROC曲线
   58   59   60   61   62   63   64   65   66   67   68