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第44卷第11期 陈 思,陈允安,张 洁,等. 多模态影像对STEMI患者急诊PCI术后MACE的预测价值[J].
2024年11月 南京医科大学学报(自然科学版),2024,44(11):1525-1533,1549 ·1529 ·
表1 两组患者临床特征比较
Table 1 Comparison of clinical characteristics between the two groups of patients
Demographics MACE(+)(n=20) MACE(-)(n=70) P
Age(years,x ± s) 62.0 ± 9.2 057.1 ± 10.6 0.063
Male[n(%)] 17(85.0) 55(78.6)% 0.751
Hypertension[n(%)] 09(45.0) 35(50.0)% 0.693
Diabetes[n(%)] 07(35.0) 28(40.0)% 0.686
Hyperlipidemia[n(%)] 09(45.0) 32(45.7)% 0.955
LAD is IRA[n(%)] 15(75.0) 29(41.4)% 0.008
Degree of stenosisof the IRA(%,x ± s) 92.9 ± 6.1 90.6 ± 6.0 0.138
Lengths of thestent(mm,x ± s) 048.0 ± 13.3 041.5 ± 14.3 0.077
GRACE score>140[n(%)] 17(85.0) 41(58.6)% 0.056
Extensive myocardial infarction[n(%)] 19(95.0) 44(62.9)% 0.013
Peak hs⁃cTnI(pg/mL,x ± s) 23 418.8 ± 7 648.0 21 818.3 ± 7 052.1 0.382
Peak NT⁃proBNP(pg/mL,x ± s) 1 296.9 ± 230.5 1 058.3 ± 450.4 0.002
Peak CRP(mg/L,x ± s) 023.5 ± 11.9 14.7 ± 5.0 0.004
Peak CK(U/L,x ± s) 03 193.5 ± 2 296.0 02 126.3 ± 1 528.5 0.017
Aspirin[n(%)] 020(100.0) 66(94.3)0 0.572
Ticagrelor[n(%)] 19(95.0) 69(98.6)0 0.924
Statins[n(%)] 19(95.0) 69(98.6)0 0.924
B⁃receptor blocker[n(%)] 020(100.0) 58(82.9)0 0.061
ARNI[n(%)] 17(85.0) 57(81.4)0 0.971
LAD:left anterior descending branch;IRA:infarction related artery;hs⁃cTnI:high sensitivity troponinI;CK:creatine kinase;ARNI:inhibitors of
angiotensin receptor enkephalinase;MACE:major adverse cardiovascular events.
表2 两组患者基线影像学参数比较
Table 2 Comparison of baselineimaging parameters betweenthe two groups ofpatients (x ± s)
MACE(+) MACE(-) MACE(+) MACE(-)
Variable P Variable P
(n=20) (n=70) (n=20) (n=70)
TTE MW(mmHg%)
TTE⁃LVEF(%) 44.1 ± 5.6 50.2 ± 6.3 <0.001 GWI 1 113.3 ± 99.20 1 322.5 ± 186.6 <0.001
TTE⁃LVEDV(mL) 130.6 ± 15.0 123.4 ± 13.3 0.049 GCW 1 332.7 ± 600.3 1 699.8 ± 447.6 0.004
TTE⁃LVESV(mL) 0 67.8 ± 11.8 0 61.8 ± 12.3 0.057 GWW 0 330.4 ± 362.0 174.2 ± 97.4 0.002
3D⁃STE(%) GWE 0 80.8 ± 10.3 87.9 ± 6.1 <0.001
GLS -9.8 ± 0.7 -11.6 ± 1.6 <0.001 LGE⁃CMR
GCS -9.4 ± 2.1 -11.5 ± 2.6 0.001 IS(%) 30.4 ± 5.3 21.9 ± 4.9 <0.001
GAS -14.9 ± 2.8 -20.2 ± 4.9 <0.001 CMR⁃LVEDV(mL) 150.9 ± 9.0 149.9 ± 9.7 0.702
GRS 20.3 ± 4.6 26.5 ± 7.0 <0.001 CMR⁃LVESV(mL) 82.2 ± 9.2 77.6 ± 9.5 0.063
CMR⁃LVEF(%) 45.3 ± 3.7 48.2 ± 4.8 0.015
GLS:global longitudinal strain;GCS:global circumferential strain;GAS:global area strain;GRS:global radial strain;MW:myocardial work;GWI:
global work index;GCW:global constructive work;GWW:global wasted work;GWE:global work efficiency;LGE⁃CMR:late gadolinium enhancement
imaging⁃cardiac magnetic resonance;IS:infarctionsize;LVEDV:left ventricular end diastolic volume;LVESV:left ventricular end systolic volume;
LVEF:left ventricular ejection fraction.
灵敏度为 100%,特异度 58.6%,GLS 和 GWI 联合预 GWI 0.830;GWI 0.830 vs. IS 0.886,GLS+GWI 0.939
测MACE发生的AUC值达0.939,灵敏度为85%,特异 vs. IS 0.886,P 均>0.05)。而 GLS+GWI 联合预测
度为90%(图3,表4)。使用DeLong方法比较AUC值 MACE 发生的价值显著优于 GLS 和 GWI 单一指标
无显著差异(GLS 0.846 vs. IS 0.886;GLS 0.846 vs. (P均<0.05)。GLS、GWI、IS预测MACE的ROC曲线