Page 75 - 南京医科大学学报自然科学版
P. 75
第44卷第2期 方 印,俞 敏,周晓凯. del Nido和HTK停搏液在成人左心室肥厚患者心脏手术中心肌保护效果
2024年2月 的比较[J]. 南京医科大学学报(自然科学版),2024,44(2):210-217 ·213 ·
表1 一般资料
Table 1 General data
Variables Group D(n=39) Group H(n=36) P
Gender[n(%)]
Male 22(56.4) 22(61.1) 0.680
Female 17(43.6) 14(38.9)
Age(years,x ± s) 059.4 ± 11.0 058.4 ± 10.0 0.685
BMI(kg/m ,x ± s) 24.7 ± 4.3 25.2 ± 3.5 0.554
2
ASA(x ± s) 03.2 ± 0.4 03.2 ± 0.5 0.496
NYHA(x ± s) 02.7 ± 0.6 02.7 ± 0.7 0.890
Hypertension[n(%)] 17(43.6) 15(41.7) 0.866
DiabetesMellitus[n(%)] 06(15.4) 04(11.1) 0.586
Hyperlipemia[n(%)] 05(12.8) 06(16.7) 0.638
COPD[n(%)] 1(2.6) 0(0.0) >0.999
Atrial fibrillation[n(%)] 07(17.9) 05(13.9) 0.632
Stroke[n(%)] 04(10.3) 2(5.6) 0.453
Smoking history[n(%)] 12(30.8) 08(22.2) 0.403
Alcohol consumption history[n(%)] 05(12.8) 07(19.4) 0.434
ACEI/ARB[n(%)] 2(5.1) 04(11.1) 0.419
β⁃blokers[n(%)] 27(69.2) 22(61.1) 0.460
Calcium blockers[n(%)] 15(38.5) 13(36.1) 0.833
Causes of left ventricular hypertrophy[n(%)] 0.141
Aortic valve stenosis 14(35.9) 19(52.8)
Hypertrophiccardiomyopathy 25(64.1) 17(47.2)
Preoperative echocardiogram
IVS(mm,x ± s) 16.6 ± 3.8 17.0 ± 4.3 0.705
LVPW(mm,x ± s) 12.4 ± 2.0 12.8 ± 2.4 0.537
LVEDD(mm,x ± s) 50.5 ± 7.7 49.0 ± 6.9 0.372
LVEF(%,x ± s) 61.0 ± 6.5 61.9 ± 5.6 0.497
LVM(g,x ± s) 316.8 ± 91.2 314.1 ± 98.6 0.904
LVMI(g/m ,x ± s) 182.9 ± 43.1 183.3 ± 54.4 0.846
2
表2 两组患者手术和体外循环情况的比较
Table 2 Comparison of surgical and cardiopulmonary bypass outcomes between the two groups
Variables Group D(n=39) Group H(n=36) P
Procedures[n(%)] 0.141
Aortic valve replacement 14(35.9) 19(52.8)
Morrow 25(64.1) 17(47.2)
Duration of procedures(min,x ± s) 0 268.3 ± 69.2 0 285.8 ± 54.7 0.229
Duration of cardiopulmonary bypass(min,x ± s) 0 132.4 ± 53.6 0 139.9 ± 48.1 0.527
Duration of aortic cross⁃clamp(min,x ± s) 0 091.9 ± 40.0 0 099.8 ± 39.2 0.386
Priming volume(mL,x ± s) 1 038.5 ± 288.0 1 033.3 ± 343.9 0.944
Cardioplegia volume(mL,x ± s) 1 566.7 ± 563.0 1 851.4 ± 587.3 0.035
Times of administering cardioplegia(x ± s) 0 001.4 ± 0.5 0 001.3 ± 0.5 0.819
Duration of administering cardioplegia(min,x ± s) 0 005.6 ± 1.2 0 008.1 ± 1.1 <0.001
2.4 两组患者心肌标志物和NT⁃proBNP的比较 行两因素重复测量方差分析,结果显示:H 组 CK⁃
T1~T3各时间点的心肌标志物和NT⁃proBNP水 MB 整体高于D组(F 组间=6.22,P=0.015),差异有统计
平见表 4。对各时间点的心肌标志物和 NT⁃proBNP 学意义;两组CK⁃MB随着时间的延长先增高后降低