Page 23 - 南京医科大学自然版

第44卷第5期 周俊发，乔婷婷，张志宏，等. 胆酸和去氧胆酸抗惊厥作用的血清代谢组学研究［J］.
2024年5月 南京医科大学学报（自然科学版），2024，44（5）：604-614 ·611 ·

Class
Class
HMDB0011719 2 Control
HMDB0001264 1 Model
HMDB0000017
HMDB0000208 0
HMDB0000251
HMDB0001160 -1
HMDB0002361 -2
HMDB0000011
HMDB0001706
HMDB0242414
HMDB0253077
HMDB0000637
HMDB0028685
HMDB0003040
HMDB0000626
HMDB0002209
HMDB0250445
HMDB0059729
HMDB0029949
HMDB0000874
HMDB0255980
HMDB0000169
HMDB0006029
HMDB0252495
HMDB0011745
C06658
HMDB0015109
HMDB0258513
HMDB0006294
HMDB0302724
HMDB0010730
HMDB0004667
HMDB0013609
HMDB0003355
HMDB0003640
HMDB0257481
HMDB0002925
HMDB0006270
HMDB0024602
Control2 Control4 Control5 Control1 Control3 Control6 Model2 Model5 Model3 Model4 Model1 Model6
图9 对照组和模型组差异代谢物热图（n=6）
Figure 9 Heat map of differential metabolites between the control group and the model group（n=6）
表2 差异化合物在各组中的相对含量
Table 2 Relative contents of differential compounds in each group （x ± s）
Compound Control group Model group CA group DCA group
## * **
Sapacitabine 1.00 ± 0.09 2.85 ± 0.17 1.34 ± 0.30 1.08 ± 0.24
### **
Linoelaidic acid 1.00 ± 0.03 1.88 ± 0.10 1.14 ± 0.05 1.78 ± 0.22
### *** ***
Pangamic acid 1.00 ± 0.21 2.17 ± 0.23 0.80 ± 0.11 1.06 ± 0.20
2⁃Oxoglutaric acid 1.00 ± 0.05 0.52 ± 0.052 ### 0.73 ± 0.03 0.79 ± 0.06 *
DL⁃Tryptophan 1.00 ± 0.53 7.32 ± 1.80 ## 2.32 ± 0.53 ** 3.35 ± 1.08 *
Taurine 1.00 ± 0.09 0.53 ± 0.03 ## 0.79 ± 0.08 0.66 ± 0.04
5⁃Aminovaleric acid 1.00 ± 0.15 5.18 ± 0.97 ### 1.93 ± 0.34 *** 1.68 ± 0.40 ***
DL⁃β⁃Leucine 1.00 ± 0.16 3.45 ± 0.48 ### 1.80 ± 0.26 ** 1.34 ± 0.27 ***
Acetyl⁃L⁃methionine 1.00 ± 0.10 2.06 ± 0.12 ### 0.76 ± 0.18 *** 0.69 ± 0.10 ***
Tricosylic acid 1.00 ± 0.15 2.09 ± 0.38 # 1.87 ± 0.09 1.12 ± 0.10 *
N⁃Acetyl⁃L⁃glutamine 1.00 ± 0.19 2.09 ± 0.12 ### 2.28 ± 0.28 2.13 ± 0.10
Arabinosylhypoxanthine 1.00 ± 0.19 3.15 ± 0.59 # 2.44 ± 0.87 1.57 ± 0.48
D⁃（+）⁃Mannose 1.00 ± 0.25 1.78 ± 0.15 ## 1.10 ± 0.05 * 1.26 ± 0.05
Homovanillic acid sulfate 1.00 ± 0.09 0.39 ± 0.06 ### 0.47 ± 0.05 0.35 ± 0.02
L⁃Alanyl⁃L⁃glutamine 1.00 ± 0.31 2.42 ± 0.34 ## 1.36 ± 0.12 1.79 ± 0.28
Ethylenediaminetetraaceti⁃c acid 1.00 ± 0.48 3.16 ± 0.33 ## 5.22 ± 1.33 5.06 ± 0.64
Pentacosanoic acid 1.00 ± 0.07 1.98 ± 0.31 # 1.19 ± 0.15 * 1.05 ± 0.09 *
4⁃Pyridoxic acid 1.00 ± 0.07 0.42 ± 0.07 # 0.85 ± 0.13 0.70 ± 0.15
Dehydroascorbic acid 1.00 ± 0.05 0.67 ± 0.08 # 0.71 ± 0.06 0.66 ± 0.06
Oxetacaine 1.00 ± 0.11 1.68 ± 0.13 ## 1.04 ± 0.07 ** 0.99 ± 0.10 ***
Fructoselysine 1.00 ± 0.22 2.19 ± 0.20 ## 1.17 ± 0.27 ** 1.26 ± 0.24 *
Proclavaminic acid 1.00 ± 0.46 2.63 ± 0.22 ## 4.30 ± 0.92 4.21 ± 0.51
Streptozotocin 1.00 ± 0.57 4.31 ± 0.39 ### 6.33 ± 1.21 6.34 ± 0.69
Convicine 1.00 ± 0.09 1.48 ± 0.15 # 1.42 ± 0.19 2.04 ± 0.09
###
*
***
**
##
##
Compared with the control group，P < 0.05，P < 0.01， P < 0.001；compared with the model group，P < 0.05，P < 0.01， P < 0.001（n=6）.