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第44卷第10期
               ·1404 ·                           南 京    医 科 大 学 学         报                        2024年10月


                                                   表1 两组患者临床资料比较
                                       Table 1 Comparison of clinical data between the two groups

                           Variable                  Non⁃LVH(n=240)              LVH(n=177)              P
                 Hypertension[n(%)]               0.0091(37.92)             000 0.97(54.80)             0.001
                 Diabetes mellitus[n(%)]          00.038(15.83)             00 00.35(19.77)             0.295
                 Age[years,M(P25,P75)]            039.00(28.25,52.00)       00.51.00(40.00,59.50)      <0.001
                 Male/Female                             171/69                    41/136              <0.001
                 BMI(kg/m ,x ± s)                      25.24 ± 3.81              23.81 ± 3.53          <0.001
                        2
                 SBP(mmHg,x ± s)                      129.18 ± 17.44            132.93 ± 19.00          0.037
                 DBP(mmHg,x ± s)                      082.17 ± 11.89            081.16 ± 12.38          0.403
                 MAP(mmHg,x ± s)                      097.84 ± 12.67            098.42 ± 12.80          0.645
                 25(OH)D[nmol/L,M(P25,P75)]       035.75(21.58,47.73)       0 032.25(21.28,45.05)       0.225
                 FBG[mmol/L,M(P25,P75)]           004.46(4.04,4.95)         00 04.54(4.16,5.10)         0.240
                 Hemoglobin(g/L,x ± s)                136.61 ± 19.72            123.22 ± 17.29         <0.001
                 Serum albumin[g/L,M(P25,P75)]    037.85(31.40,40.90)       0 035.70(28.25,38.65)       0.014
                 eGFR[mL/min/1.73 m ,M(P25,P75)]  097.05(74.89,115.26)      0 088.42(62.36,106.46)      0.005
                                 2
                 TG[mmol/L,M(P25,P75)]            001.49(1.01,2.23)         0001.42(0.92,2.13)          0.629
                 TC[mmol/L,M(P25,P75)]            004.81(4.09,5.97)         0 004.86(4.15,6.05)         0.912
                 LDL⁃C[mmol/L,M(P25,P75)]         003.08(2.45,3.74)         0 002.93(2.38,3.71)         0.507
                 Calcium[mmol/L,M(P25,P75)]       002.21(2.08,2.30)         0 002.17(2.06,2.28)         0.231
                 Phosphorus[mmol/L,M(P25,P75)]    001.24(1.12,1.36)         00 01.26(1.17,1.35)         0.320
                 24hUP[mg,M(P25,P75)]             776.00(294.75,2 892.50)   1 109.00(217.50,2 861.50)   0.629


                      表2 两组患者间慢性肾脏病分期比较                                    表3 两组患者间病理类型比较
              Table 2  Comparison of CKD stage between the two   Table 3  Comparison of pathological types between the
                       groups of patients          [n(%)]                two groups of patients       [n(%)]
                 CKD stage       Non⁃LVH           LVH                                Non⁃LVH     LVH
                 1(n=226)        140(61.95)      86(38.05)           Pathological type  (n=240) (n=177)    P
                 2(n=114)         63(55.26)      51(44.74)        Membranous nephropathy 036(15.00) 28(15.82) 0.082
                 3(n=77)          37(48.05)      40(51.95)        IgA nephropathy     104(43.33) 58(32.77)
                  2
                 χ =4.876,P=0.087.                                FSGS                050(20.83) 37(20.90)
                                                                  Diabetic nephropathy  010(4.17) 19(10.73)
              处于同样的高血压水平下,中青年女性发生LVH的                             Minimal change disease  008(3.33) 05(2.83)
              风险高于男性,性别差异可能是由于正常情况下                               HSPN                015(6.25) 10(5.65)
              该年龄段女性血压远低于男性,伴发高血压时女                               Lupus nephritis     004(1.67) 08(4.52)
              性心脏和肾脏承受的血流动力学负荷比同龄男性                               Other               013(5.42) 12(6.78)
              更大  [18-19] 。可见同样的高血压水平对CKD 1~3期的                     FSGS:focal segmental glomerulosclerosis;HSPN:Henoch ⁃
                                                                                    2
              女性影响更大,对此类患者的高血压进行积极控制                             Schönlein Purpura Nephritis. χ =12.633,P=0.082.

                                               表4   两组间生物电阻抗检测指标比较
                                      Table 4  Comparison of BIA indicators between the two groups

                            Variable                Non⁃LVH(n=240)            LVH(n=177)              P
                    LTM(kg,x ± s)                     46.42 ± 11.46           37.48 ± 9.20          <0.001
                    ATM(kg,x ± s)                     25.36 ± 12.56           23.36 ± 9.75           0.071
                    LTI(kg/m ,x ± s)                  16.20 ± 3.320           14.41 ± 3.08          <0.001
                           2
                    FTI(kg/m ,x ± s)                   8.96 ± 4.51            09.27 ± 3.94           0.471
                           2
                    Over hydration[L,M(P25,P75)]    0.10(-0.68,1.38)        0.30(-0.40,1.70)         0.139
                    LTM/ATM[M(P25,P75)]             1.81(1.19,3.07)         1.58(1.08,2.43)          0.013
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