Page 88 - 南京医科大学自然版
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第44卷第10期
·1404 · 南 京 医 科 大 学 学 报 2024年10月
表1 两组患者临床资料比较
Table 1 Comparison of clinical data between the two groups
Variable Non⁃LVH(n=240) LVH(n=177) P
Hypertension[n(%)] 0.0091(37.92) 000 0.97(54.80) 0.001
Diabetes mellitus[n(%)] 00.038(15.83) 00 00.35(19.77) 0.295
Age[years,M(P25,P75)] 039.00(28.25,52.00) 00.51.00(40.00,59.50) <0.001
Male/Female 171/69 41/136 <0.001
BMI(kg/m ,x ± s) 25.24 ± 3.81 23.81 ± 3.53 <0.001
2
SBP(mmHg,x ± s) 129.18 ± 17.44 132.93 ± 19.00 0.037
DBP(mmHg,x ± s) 082.17 ± 11.89 081.16 ± 12.38 0.403
MAP(mmHg,x ± s) 097.84 ± 12.67 098.42 ± 12.80 0.645
25(OH)D[nmol/L,M(P25,P75)] 035.75(21.58,47.73) 0 032.25(21.28,45.05) 0.225
FBG[mmol/L,M(P25,P75)] 004.46(4.04,4.95) 00 04.54(4.16,5.10) 0.240
Hemoglobin(g/L,x ± s) 136.61 ± 19.72 123.22 ± 17.29 <0.001
Serum albumin[g/L,M(P25,P75)] 037.85(31.40,40.90) 0 035.70(28.25,38.65) 0.014
eGFR[mL/min/1.73 m ,M(P25,P75)] 097.05(74.89,115.26) 0 088.42(62.36,106.46) 0.005
2
TG[mmol/L,M(P25,P75)] 001.49(1.01,2.23) 0001.42(0.92,2.13) 0.629
TC[mmol/L,M(P25,P75)] 004.81(4.09,5.97) 0 004.86(4.15,6.05) 0.912
LDL⁃C[mmol/L,M(P25,P75)] 003.08(2.45,3.74) 0 002.93(2.38,3.71) 0.507
Calcium[mmol/L,M(P25,P75)] 002.21(2.08,2.30) 0 002.17(2.06,2.28) 0.231
Phosphorus[mmol/L,M(P25,P75)] 001.24(1.12,1.36) 00 01.26(1.17,1.35) 0.320
24hUP[mg,M(P25,P75)] 776.00(294.75,2 892.50) 1 109.00(217.50,2 861.50) 0.629
表2 两组患者间慢性肾脏病分期比较 表3 两组患者间病理类型比较
Table 2 Comparison of CKD stage between the two Table 3 Comparison of pathological types between the
groups of patients [n(%)] two groups of patients [n(%)]
CKD stage Non⁃LVH LVH Non⁃LVH LVH
1(n=226) 140(61.95) 86(38.05) Pathological type (n=240) (n=177) P
2(n=114) 63(55.26) 51(44.74) Membranous nephropathy 036(15.00) 28(15.82) 0.082
3(n=77) 37(48.05) 40(51.95) IgA nephropathy 104(43.33) 58(32.77)
2
χ =4.876,P=0.087. FSGS 050(20.83) 37(20.90)
Diabetic nephropathy 010(4.17) 19(10.73)
处于同样的高血压水平下,中青年女性发生LVH的 Minimal change disease 008(3.33) 05(2.83)
风险高于男性,性别差异可能是由于正常情况下 HSPN 015(6.25) 10(5.65)
该年龄段女性血压远低于男性,伴发高血压时女 Lupus nephritis 004(1.67) 08(4.52)
性心脏和肾脏承受的血流动力学负荷比同龄男性 Other 013(5.42) 12(6.78)
更大 [18-19] 。可见同样的高血压水平对CKD 1~3期的 FSGS:focal segmental glomerulosclerosis;HSPN:Henoch ⁃
2
女性影响更大,对此类患者的高血压进行积极控制 Schönlein Purpura Nephritis. χ =12.633,P=0.082.
表4 两组间生物电阻抗检测指标比较
Table 4 Comparison of BIA indicators between the two groups
Variable Non⁃LVH(n=240) LVH(n=177) P
LTM(kg,x ± s) 46.42 ± 11.46 37.48 ± 9.20 <0.001
ATM(kg,x ± s) 25.36 ± 12.56 23.36 ± 9.75 0.071
LTI(kg/m ,x ± s) 16.20 ± 3.320 14.41 ± 3.08 <0.001
2
FTI(kg/m ,x ± s) 8.96 ± 4.51 09.27 ± 3.94 0.471
2
Over hydration[L,M(P25,P75)] 0.10(-0.68,1.38) 0.30(-0.40,1.70) 0.139
LTM/ATM[M(P25,P75)] 1.81(1.19,3.07) 1.58(1.08,2.43) 0.013

