Page 143 - 南京医科大学自然版

第45卷第10期 张宇烨，顾彰琦，钱伟峰. 癌症相关成纤维细胞在乳腺癌转移中的研究进展［J］.
2025年10月 南京医科大学学报（自然科学版），2025，45（10）：1502-1512 ·1511 ·

（12）：1439-1448 metabolic coupling［J］. EBioMedicine，2019，41：370-
［26］WEN S，HOU Y，FU L，et al. Cancer⁃associated fibroblast 383
（CAF）⁃derived IL32 promotes breast cancer cell invasion ［38］BECKER L M，O’CONNELL J T，VO A P，et al. Epigene⁃
and metastasis via integrin β3⁃p38 MAPK signalling［J］. tic reprogramming of cancer⁃associated fibroblasts deregu⁃
Cancer Lett，2019，442：320-332 lates glucose metabolism and facilitates progression of
［27］CIRILLO F，PELLEGRINO M，TALIA M，et al. Estrogen breast cancer［J］. Cell Rep，2020，31（9）：107701
receptor variant ERα46 and insulin receptor drive in pri⁃ ［39］YAN W，WU X，ZHOU W，et al. Cancer⁃cell⁃secreted exo⁃
mary breast cancer cells growth effects and interleukin 11 somal miR⁃105 promotes tumour growth through the MYC⁃
induction prompting the motility of cancer⁃associated fi⁃ dependent metabolic reprogramming of stromal cells［J］.
broblasts［J］. Clin Transl Med，2021，11（11）：e516 Nat Cell Biol，2018，20（5）：597-609
［28］XI L，PENG M，LIU S，et al. Hypoxia⁃stimulated ATM ［40］DE JAEGHERE E A，DENYS H G，DE WEVER O. Fibro⁃
activation regulates autophagy⁃associated exosome release blasts fuel immune escape in the tumor microenvironment
from cancer⁃associated fibroblasts to promote cancer cell ［J］. Trends Cancer，2019，5（11）：704-723
invasion［J］. J Extracell Vesicles，2021，10（11）：e12146 ［41］GOK YAVUZ B，GUNAYDIN G，GEDIK M E，et al. Can⁃
［29］SCOGNAMIGLIO I，COCCA L，PUOTI I，et al. Erratum： cer associated fibroblasts sculpt tumour microenviron⁃
Exosomal microRNAs synergistically trigger stromal fibro⁃ ment by recruiting monocytes and inducing immunosup⁃
blasts in breast cancer［J］. Mol Ther Nucleic Acids， pressive PD⁃1+ TAMs［J］. Sci Rep，2019，9（1）：3172
2022，29：656 ［42］TOKUDA K，MORINE Y，MIYAZAKI K，et al. The inter⁃
［30］DONNARUMMA E，FIORE D，NAPPA M，et al. Cancer⁃ action between cancer associated fibroblasts and tumor as⁃
associated fibroblasts release exosomal microRNAs that sociated macrophages via the osteopontin pathway in the
dictate an aggressive phenotype in breast cancer［J］. On⁃ tumor microenvironment of hepatocellular carcinoma［J］.
cotarget，2017，8（12）：19592-19608 Oncotarget，2021，12（4）：333-343
［31］LIU Y，YANG Y，DU J，et al. MiR⁃3613⁃3p from carcino⁃ ［43］JIN K，PANDEY N B，POPEL A S. Crosstalk between stro⁃
ma⁃associated fibroblasts exosomes promoted breast can⁃ mal components and tumor cells of TNBC via secreted fac⁃
cer cell proliferation and metastasis by regulating SOCS2 tors enhances tumor growth and metastasis［J］. Oncotar⁃
expression［J］. IUBMB Life，2020，72（8）：1705-1714 get，2017，8（36）：60210-60222
［32］YAN Z，SHENG Z，ZHENG Y，et al. Cancer⁃associated fi⁃ ［44］KIEFFER Y，HOCINE H R，GENTRIC G，et al. Single⁃
broblast⁃derived exosomal miR⁃18b promotes breast can⁃ cell analysis reveals fibroblast clusters linked to immuno⁃
cer invasion and metastasis by regulating TCEAL7［J］. therapy resistance in cancer［J］. Cancer Discov，2020，10
Cell Death Dis，2021，12（12）：1120 （9）：1330-1351
［33］TAO S，LI H，MA X，et al. Elevating microRNA⁃1⁃3p shut⁃ ［45］FANG J，XIAO L，JOO K I，et al. A potent immunotoxin
tled by cancer⁃associated fibroblasts⁃derived extracellular targeting fibroblast activation protein for treatment of
vesicles suppresses breast cancer progression and metas⁃ breast cancer in mice［J］. Int J Cancer，2016，138（4）：
tasis by inhibiting GLIS1［J］. Cancer Gene Ther，2021，28 1013-1023
（6）：634-648 ［46］GENG F，BAO X，DONG L，et al. Doxorubicin pretreat⁃
［34］CHEN B，SANG Y，SONG X，et al. Exosomal miR⁃500a⁃ ment enhances FAPα/survivin co⁃targeting DNA vaccine
5p derived from cancer ⁃ associated fibroblasts promotes anti⁃tumor activity primarily through decreasing peripher⁃
breast cancer cell proliferation and metastasis through tar⁃ al MDSCs in the 4T1 murine breast cancer model［J］. On⁃
geting USP28［J］. Theranostics，2021，11（8）：3932⁃3947 coimmunology，2020，9（1）：1747350
［35］FRANCHI M，PIPERIGKOU Z，KARAMANOS K A，et al. ［47］DAS S，VALTON J，DUCHATEAU P，et al. Stromal deple⁃
Extracellular matrix⁃mediated breast cancer cells morpho⁃ tion by TALEN⁃edited universal hypoimmunogenic FAP⁃
logical alterations，invasiveness，and microvesicles/exo⁃ CAR T cells enables infiltration and anti⁃tumor cytotoxicity
somes release［J］. Cells，2020，9（9）：2031 of tumor antigen ⁃ targeted CAR ⁃ T immunotherapy［J］.
［36］LI Z，SUN C，QIN Z. Metabolic reprogramming of cancer⁃ Front Immunol，2023，14：1172681
associated fibroblasts and its effect on cancer cell repro⁃ ［48］RIVAS E I，LINARES J，ZWICK M，et al. Targeted immu⁃
gramming［J］. Theranostics，2021，11（17）：8322-8336 notherapy against distinct cancer ⁃ associated fibroblasts
［37］SUN K，TANG S，HOU Y，et al. Oxidized ATM⁃mediated overcomes treatment resistance in refractory HER2 +
glycolysis enhancement in breast cancer⁃associated fibro⁃ breast tumors［J］. Nat Commun，2022，13（1）：5310
blasts contributes to tumor invasion through lactate as ［49］FORMENTI S C，LEE P，ADAMS S，et al. Focal irradia⁃