Page 100 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第2期
·240 · Journal of Nanjing Medical University（Natural Sciences） 2025年2月

·临床研究·

运用超声心动图多模态参数评估肥厚型心肌病患者早期左心

室功能变化

张艳娟 ，王璎瑛 ，赵 迪 ，吴红平 ，孙 伟 ，雍永宏 1*
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南京医科大学第一附属医院心血管内科，老年医学科，江苏 南京 210029
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［摘 要］ 目的：运用超声心动图的多模态参数评估肥厚型心肌病（hypertrophic cardiomyopathy，HCM）患者早期左心室收缩
及舒张功能的变化。方法：选取2019年10月—2021年6月在南京医科大学第一附属医院门诊就诊的HCM患者共54例，其中
包括非梗阻性HCM患者34例和梗阻性HCM患者20例，同时选择30例正常人作为对照组，运用超声心动图的多模态参数，比
较3组间左心室收缩及舒张功能的变化。结果：HCM患者左室收缩功能及舒张功能均降低，其中梗阻性HCM患者左心室整体
长轴应变（global longitudinal strain，GLS）、整体做功指数（global work index，GWI）、整体有效功（global constructive work，GCW）、
整体做功效率（global work efficiency，GWE）降低更为明显，整体无效功（global waste work，GWW）在 3 组间差异无统计学意
义。结论：超声心动图的多模态参数可以早期全面地评价HCM患者左室收缩及舒张功能的受损情况，为临床诊疗及预后提供
重要依据。
［关键词］ 压力⁃应变环；肥厚型心肌病；左心室做功；左心室舒张功能
［中图分类号］ R445.1 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）02⁃240⁃06
doi：10.7655/NYDXBNSN241008

Assessment of early left ventricular functional changes in HCM patients by multimodality
echocardiographic parameters
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ZHANG Yanjuan ，WANG Yingying ，ZHAO Di ，WU Hongping ，SUN Wei ，YONG Yonghong 1*
Department of Cardiology，Department of Geriatrics，the First Affiliated Hospital of Nanjing Medical University，
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Nanjing 210029，China
［Abstract］ Objective：The aim of this study was using multimodality echocardiographic parameters to evaluate early changes in
systolic and diastolic functions of left ventricle in patients with hypertrophic cardiomyopathy（HCM）. Methods：A total of 54 HCM
patients were selected，including 34 with non ⁃ obstructive HCM patients and 20 with obstructive HCM patients，who visited the
outpatient department of the First Affiliated Hospital of Nanjing Medical University from October 2019 to June 2021. Additionally，30
healthy individuals were chosen as a control group. Multimodality echocardiographic parameters were used to compare the changes in
left ventricular systolic and diastolic functions among three groups. Results：HCM patients exhibited reduced left ventricular systolic
and diastolic function. Obstructive HCM patients showed more significant reduction in global longitudinal strain（GLS），global work
index（GWI），global constructive work（GCW），and global work efficiency（GWE）. The difference in global waste work（GWW）among
the three groups was not statistically significant. Conclusion：Multimodality echocardiographic parameters can comprehensively
evaluate the early impairment of left ventricular systolic and diastolic functions in HCM patients，providing important basis for clinical
diagnosis，treatment，and prognosis as early as possible.
［Key words］ pressure⁃strain loop；hypertrophic cardiomyopathy；left ventricular work；left ventricular diastolic function
［J Nanjing Med Univ，2025，45（02）：240⁃244，259］

［基金项目］ 国家自然科学基金（82270362）
通信作者（Corresponding author），E⁃mail：yongyonghong@163.com（ORCID：0009⁃0004⁃4957⁃9073）
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