Page 137 - 南京医科大学自然版
P. 137

第45卷第5期                 李佳欣,陶善东,于 亮. KMT2A重排急性髓系白血病的研究进展[J].
                  2025年5月                     南京医科大学学报(自然科学版),2025,45(5):718-726                        ·723 ·


                     Cell Dev Biol,2019,7:81                           leukemia:determination of prognostic significance of rare
               [11]MACPHERSON L,ANOKYE J,YEUNG M M,et al.              recurring chromosomal abnormalities among 5 876 younger
                    HBO1 is required for the maintenance of leukaemia stem  adult patients treated in the United Kingdom Medical
                    cells[J]. Nature,2020,577(7789):266-270            Research Council trials[J]. Blood,2010,116(3):354-
               [12] MEYER C,LARGHERO P,ALMEIDA LOPES B,et al.          365
                    The KMT2A recombinome of acute leukemias in 2023[J].  [21]LOPES B A,POUBEL C P,TEIXEIRA C E,et al. Novel
                    Leukemia,2023,37(5):988-1005                       diagnostic and therapeutic options for KMT2A⁃rearranged
               [13]LI Z J,CHEN P,SU R,et al. PBX3 and MEIS1 Cooperate  acute leukemias[J]. Front Pharmacol,2022,13:749472
                    in hematopoietic cells to drive acute myeloid leukemias  [22] CASLINI C,YANG Z H,EL⁃OSTA M,et al. Interaction
                    characterized by a core transcriptome of the MLL ⁃ rear⁃  of MLL amino terminal sequences with menin is required
                    ranged disease(Article)[J]. Cancer Res,2016,76(3):  for transformation[J]. Cancer Res,2007,67(15):7275-
                    619-629                                            7283
               [14] ESPOSITO M T,ZHAO L,FUNG T K,et al. Synthetic  [23]YOKOYAMA A,SOMERVAILLE T C P,SMITH K S,
                    lethal targeting of oncogenic transcription factors in acute  et al. The menin tumor suppressor protein is an essential
                    leukemia by PARP inhibitors[J]. Nat Med,2015,21    oncogenic cofactor for MLL ⁃ associated leukemogenesis
                    (12):1481-1490                                    [J]. Cell,2005,123(2):207-218
               [15] MIYAMOTO R,KANAI A,OKUDA H,et al. HOXA9      [24]GREMBECKA J,HE S H,SHI A B,et al. Menin⁃MLL
                     promotes MYC⁃mediated leukemogenesis by maintaining  inhibitors reverse oncogenic activity of MLL fusion
                     gene expression for multiple anti⁃apoptotic pathways[J].  proteins in leukemia[J]. Nat Chem Biol,2012,8(3):
                     Elife,2021,10:e64148                              277-284
               [16]强    萍,丁凯阳. MLL基因重排成人急性B淋巴细胞白                 [25]SHI A B,MURAI M J,HE S H,et al. Structural insights
                    血病和急性髓系白血病临床特征及预后危险因素分                             into inhibition of the bivalent menin⁃MLL interaction by
                    析[J]. 安徽医学,2023,44(4):367-371                      small molecules in leukemia[J]. Blood,2012,120(23):
                    QIANG P,DING K Y. The clinical characteristics and  4461-4469
                    prognostic risk factors of B ⁃ lymphoblastic leukemia and  [26]ZHANG M ,AGUILAR A ,XU S ,et al. Discovery of
                    acute myelogenous leukemia with MLL gene rearrange⁃  M⁃1121 as an orally active covalent inhibitor of menin⁃
                    ment[J]. Anhui Medical Journal,2023,44(4):367-371  MLL interaction capable of achieving complete and long⁃
               [17] KONOPLEV S,WANG X Q,TANG G L,et al. Compre⁃        lasting tumor regression[J]. J Med Chem,2021,64(14):
                    hensive immunophenotypic study of acute myeloid leuke⁃  10333-10349
                    mia with KMT2A(MLL)rearrangement in adults:a single⁃  [27] ISSA G C,ALDOSS I,THIRMAN M J,et al. Menin inhi⁃
                    institution experience[J]. Cytometry B Clin Cytom,2022,  bition with revumenib for KMT2A⁃rearranged relapsed or
                    102(2):123-133                                     refractory acute leukemia(AUGMENT ⁃ 101)[J]. J Clin
               [18]王    彤,赵   燕,张青青,等. 成人 AML 伴 MLL 重排患                Oncol,2024,43(1):75-84
                    者临床特征及预后影响因素探讨[J]. 中国实验血液学                   [28]CHENG M,GE L,GAO Z H,et al. Abstract 2113:HMPL⁃
                    杂志,2020,28(3):775-780                              506,a novel,highly potent and differentiated menin⁃MLL
                    WANG T,ZHAO Y,ZHANG Q Q,et al. Clinical charac⁃    inhibitor for the treatment of MLL ⁃ rearrangedand
                    teristics and prognostic influencing factors of adult AML  NPM1mutant acute leukemia in preclinical models[J].
                    patients with MLL rearrangement[J]. Journal of Experi⁃  Cancer Res,2024,84(6_Supplement):2113
                    mental Hematology,2020,28(3):775-780         [29]WANG E S,ALTMAN J K,PETTIT K,et al. Preliminary
               [19]弓晓媛,王      迎,刘兵城,等. MLL基因重排成人急性髓                    data on a phase 1/2A first in human study of the menin⁃
                    系白血病的特征和预后分析[J]. 中华血液学杂志,                          KMT2A(MLL)inhibitor KO⁃539 in patients with relapsed
                    2018,39(1):9-14                                    or refractory acute myeloid leukemia[J]. Blood,2020,
                    GONG X Y,WANG Y,LIU B C,et al. Characteristics     136(1):7-8
                    and prognosis in adult acute myeloid leukemia patients  [30]DAVER N,ZEIDNER J F,YUDA J,et al. Phase 1/2 first⁃
                    with MLL gene rearrangements[J]. Chinese Journal of  in⁃human study of the menin⁃MLL inhibitor DSP⁃5336 in
                    Hematology,2018,39(1):9-14                         patients with relapsed or refractory acute leukemia[J].
               [20] GRIMWADE D,HILLS R K,MOORMAN A V,et al.            Blood,2023,142(Supplement 1):2911
                    Refinement of cytogenetic classification in acute myeloid  [31]THOMAS X. Small molecule menin inhibitors:novel ther⁃
   132   133   134   135   136   137   138   139   140   141   142