Page 50 - 南京医科大学自然版
P. 50
第45卷第5期
·636 · 南 京 医 科 大 学 学 报 2025年5月
injury and fibrosis by obstructive cholestasis［J］. J Vis ［20］SUN X W，CUI Q，NI J，et al. Gut microbiota mediates the
Exp，2015（96）：52438 therapeutic effect of monoclonal anti ⁃ TLR4 antibody on
［12］POLLHEIMER M J，TRAUNER M，FICKERT P. Will we acetaminophen⁃induced acute liver injury in mice［J］. Mi⁃
ever model PSC?⁃“it’s hard to be a PSC model!”［J］. Clin crobiol Spectr，2022，10（3）：e0064722
Res Hepatol Gastroenterol，2011，35（12）：792-804 ［21］ISHAK K，BAPTISTA A，BIANCHI L，et al. Histological
［13］ VAN CAMPENHOUT S，VAN VLIERBERGHE H，DE⁃ grading and staging of chronic hepatitis［J］. J Hepatol，
VISSCHER L. Common bile duct ligation as model for 1995，22（6）：696-699
secondary biliary cirrhosis［J］. Methods Mol Biol，2019， ［22］LI J，ZHU X Y，ZHANG M H，et al. Limb expression 1⁃
1981：237-247 like（LIX1L）protein promotes cholestatic liver injury by
［14］CARPENTER⁃DEYO L，MARCHAND D H，JEAN P A， regulating bile acid metabolism［J］. J Hepatol，2021，75
et al. Involvement of glutathione in 1⁃naphthylisothiocya⁃ （2）：400-413
nate（ANIT）metabolism and toxicity to isolated hepato⁃ ［23］WANG M Q，ZHANG K H，LIU F L，et al. Wedelolactone
cytes［J］. Biochem Pharmacol，1991，42（11）：2171- alleviates cholestatic liver injury by regulating FXR⁃bile
2180 acid⁃NF⁃κB/NRF2 axis to reduce bile acid accumulation
［15］ASSIS D N，BOWLUS C L. Recent advances in the man⁃ and its subsequent inflammation and oxidative stress［J］.
agement of primary sclerosing cholangitis［J］. Clin Gastro⁃ Phytomedicine，2024，122：155124
enterol Hepatol，2023，21（8）：2065-2075 ［24］ LABIANO I，AGIRRE-LIZASO A，OLAIZOLA P，et al.
［16］RAUF A，KHALIL A A，RAHMAN U U，et al. Recent ad⁃ TREM⁃2 plays a protective role in cholestasis by acting
vances in the therapeutic application of short⁃chain fatty as a negative regulator of inflammation［J］. J Hepatol，
acids（SCFAs）：an updated review［J］. Crit Rev Food Sci 2022，77（4）：991-1004
Nutr，2022，62（22）：6034-6054 ［25］WANG Z，ZHANG X X，ZHU L L，et al. Inulin alleviates
［17］ZHANG S M，ZHAO J W，XIE F，et al. Dietary fiber⁃ inflammation of alcoholic liver disease via SCFAs⁃induc⁃
derived short ⁃ chain fatty acids：a potential therapeutic ing suppression of M1 and facilitation of M2 macrophages
target to alleviate obesity⁃related nonalcoholic fatty liver in mice［J］. Int Immunopharmacol，2020，78：106062
disease［J］. Obes Rev，2021，22（11）：e13316 ［26］ WANG W，ZHAO X，MA Y，et al. Alleviating effect of
［18］ SHASHNI B，TAJIKA Y，IKEDA Y，et al. Self ⁃ assem⁃ Lacticaseibacillus rhamnosus 1.0320 combined with dihy⁃
bling polymer⁃based short chain fatty acid prodrugs ame⁃ dromyricetin on acute alcohol exposure⁃induced hepatic
liorate non⁃alcoholic steatohepatitis and liver fibrosis［J］. impairment：based on short⁃chain fatty acids and adenos⁃
Biomaterials，2023，295：122047 ine 5’⁃monophosphate⁃activated protein kinase⁃mediated
［19］AWONIYI M，WANG J，NGO B，et al. Protective and ag⁃ lipid metabolism signaling pathway［J］. J Agric Food
gressive bacterial subsets and metabolites modify hepato⁃ Chem，2023，71（12）：4837-4850
biliary inflammation and fibrosis in a murine model of ［收稿日期］ 2025-01-22
PSC［J］. Gut，2023，72（4）：671-685 （本文编辑：戴王娟）
