Page 55 - 南京医科大学自然版

第45卷第5期 张嘉男，李沣员，李清雅，等. 优化淋巴结比率预测淋巴结转移阳性胃癌患者预后研究［J］.
2025年5月 南京医科大学学报（自然科学版），2025，45（5）：637-643，651 ·641 ·

表2 影响淋巴结转移阳性胃癌患者生存单因素及多因素分析
Table 2 Univariate and multivariate analysis of factors affecting survival in gastric cancer patients with positive lymph node
metastasis
Univariate analysis Multivariate analysis
Characteristic
HR 95%CI P HR 95%CI P
Age
<65 years Reference - - Reference - -
≥65 years 1.868 1.442-2.419 <0.001 1.759 1.353-2.289 <0.001
Sex
Female Reference - - - - -
Male 1.006 0.754-1.342 0.967 - - -
Gastrectomy
Total Reference - - Reference - -
Others 0.650 0.501-0.845 0.001 0.905 0.689-1.189 0.473
Tumor site 0.479
U Reference - - - - -
M 0.859 0.586-1.260 0.437 - - -
L 0.847 0.641-1.120 0.244 - - -
Tumor size
<4 cm Reference - - Reference - -
≥4 cm 1.755 1.327-2.321 <0.001 1.142 0.852-1.532 0.373
Differentiation
Moderate Reference - - - - -
Poor 1.502 0.890-2.535 0.127 - - -
Vascular invasion
Absent Reference - - Reference - -
Present 1.526 1.161-2.006 0.002 1.077 0.806-1.438 0.618
Neural invasion
Absent Reference - - Reference - -
Present 1.976 1.508-2.590 <0.001 1.216 0.906-1.631 0.193
T stage <0.001 <0.001
T1 Reference - - Reference - -
T2 2.042 0.755-5.521 0.160 1.375 0.504-3.747 0.534
T3 4.850 2.128-11.056 <0.001 2.481 1.047-5.876 0.039
T4 8.426 3.707-19.149 <0.001 3.960 1.660-9.448 0.002
CEA
Normal Reference - - Reference - -
Elevated 1.707 1.291-2.257 <0.001 1.415 1.062-1.885 0.018
AFP
Normal Reference - - - - -
Elevated 1.341 0.807-2.228 0.258 - - -
CA199
Normal Reference - - Reference - -
Elevated 1.762 1.329-2.336 <0.001 1.283 0.960-1.715 0.093
mLNR <0.001 <0.001
mLNR1 Reference - - Reference - -
mLNR2 1.264 0.885-1.807 0.198 1.057 0.733-1.523 0.766
mLNR3 3.016 1.983-4.588 <0.001 2.378 1.538-3.676 <0.001
mLNR4 3.378 2.470-4.618 <0.001 2.484 1.792-3.443 <0.001