Page 45 - 南京医科大学自然版

第45卷第5期 路 寒，张雪飞，孙学伟，等. 两种小鼠模型在胆汁淤积性肝损伤实验中的应用［J］.
2025年5月 南京医科大学学报（自然科学版），2025，45（5）：627-636 ·631 ·

A Control Sham BDL ANIT

1 week

2 weeks

B Control Sham BDL ANIT

× 100

week
1

× 400

C Control Sham BDL ANIT

× 100
2 weeks

× 400

D
5 5
week 4 BDL 2 weeks BDL
ANIT
ANIT
1 3 4 3 * *
Pathological score 2 1 * * Pathological score 2 1

0 0
Portal fibrosis
Biliary proliferation
Portal fibrosis Biliary proliferation Inflammatory infiltration Hepatic necrosis
Inflammatory infiltration
Hepatic necrosis

A：Gross morphological features of liver tissues across experimental groups. B，C：H&E staining of hepatic tissues at 1 week and 2 weeks intervals
post⁃induction（black arrows：necrotic foci；yellow arrows：portal connective tissue hyperplasia；blue arrows：inflammatory cell infiltration；red arrows：
ductular proliferation；×100，×400）. D：Semiquantitative assessment of liver injury severity in the two experimental models. Compared to the ANIT
*
group，P < 0.05（n=6）.
图2 BDL和ANIT模型肝脏病变的组织病理学对比分析
Figure 2 Comparative histopathological analysis of hepatic lesions in BDL and ANIT models