Page 40 - 南京医科大学自然版
P. 40
第45卷第5期
·626 · 南 京 医 科 大 学 学 报 2025年5月
[7] MU R,LI C,LI X M,et al. Effectiveness and safety of igu⁃ pendent interaction between inflammatory fibroblasts and
+
ratimod treatment in patients with active rheumatoid ar⁃ FOLR2 macrophages promotes fibrosis in chronic kidney
thritis in chinese:a nationwide,prospective real ⁃ world disease[J]. Nat Commun,2024,15(1):743
study[J]. Lancet Reg Health West Pac,2021,10:100128 [16]邱郁梅,何伟春. 肾脏纤维化患者肌成纤维细胞来源的
[8] LI J,BAO J,ZENG J,et al. Iguratimod:a valuable reme⁃ 研究进展[J]. 中国医药,2018,13(9):1437-1440
dy from the Asia Pacific region for ameliorating autoim⁃ QIU Y M,HE W C. Originating sites of myofibroblasts in
mune diseases and protecting bone physiology[J]. Bone renal fibrosis[J]. China Medicine,2018,13(9):1437-
Res,2019,7:27 1440
[9] LIU W P,HAN X,LI Q,et al. Iguratimod ameliorates bleo⁃ [17]TOKI D,ZHANG W,HOR K L M,et al. The role of mac⁃
mycin⁃induced pulmonary fibrosis by inhibiting the EMT rophages in the development of human renal allograft fi⁃
process and NLRP3 inflammasome activation[J]. Biomed⁃ brosis in the first year after transplantation[J]. Am J
ecine Pharmacother,2022,153:113460 Transplant,2014,14(9):2126-2136
[10]SHAO S Q,QU Z Y,LIANG Y W,et al. Iguratimod de⁃ [18]TANG P M K,NIKOLIC⁃PATERSON D J,LAN H Y. Mac⁃
creases bleomycin⁃induced pulmonary fibrosis in associa⁃ rophages:versatile players in renal inflammation and fi⁃
tion with inhibition of TNF⁃ α in mice[J]. Int Immuno⁃ brosis[J]. Nat Rev Nephrol,2019,15(3):144-158
pharmacol,2021,99:107936 [19]WANG Y J,LI Y S,CHEN Z M,et al. GSDMD⁃dependent
[11]蔡欣诺,邵思琪,马 华,等. 艾拉莫德通过抑制TNF⁃α neutrophil extracellular traps promote macrophage ⁃ to ⁃
减轻博来霉素诱导的小鼠间质性肺病[J]. 中华肺部疾 myofibroblast transition and renal fibrosis in obstructive
病杂志(电子版),2022,15(3):331-334 nephropathy[J]. Cell Death Dis,2022,13(8):693
CAI X N,SHAO S Q,MA H,et al. Iguratimod decreases [20]MENG X M,WANG S,HUANG X R,et al. Inflammatory
bleomycin⁃induced pulmonary fibrosis in association with macrophages can transdifferentiate into myofibroblasts
inhibition of TNF⁃α in mice[J]. Chinese Journal Of Lung during renal fibrosis[J]. Cell Death Dis,2016,7(12):e2495
Diseases(Electronic Edition),2022,15(3):331-334 [21]JIANG X J,STOCKWELL B R,CONRAD M. Ferroptosis:
[12]ZHANG Y,ZHANG J J,FENG D Y,et al. IRF1/ZNF350/ mechanisms,biology and role in disease[J]. Nat Rev Mol
GPX4 ⁃ mediated ferroptosis of renal tubular epithelial Cell Biol,2021,22(4):266-282
cells promote chronic renal allograft interstitial fibrosis[J]. [22]CUI W W,LIU D,GU W,et al. Peroxisome⁃driven ether⁃
Free Radic Biol Med,2022,193(Pt 2):579-594 linked phospholipids biosynthesis is essential for ferropto⁃
[13]HANG Z,WEI J T,ZHENG M,et al. Iguratimod attenu⁃ sis[J]. Cell Death Differ,2021,28(8):2536-2551
ates macrophage polarization and antibody ⁃ mediated re⁃ [23]ZHU B W,NI Y F,GONG Y,et al. Formononetin amelio⁃
jection after renal transplant by regulating KLF4[J]. rates ferroptosis⁃associated fibrosis in renal tubular epi⁃
Front Pharmacol,2022,13:865363 thelial cells and in mice with chronic kidney disease by
[14]MAYRDORFER M,LIEFELDT L,WU K Y,et al. Explor⁃ suppressing the Smad3/ATF3/SLC7A11 signaling[J].
ing the complexity of death⁃censored kidney allograft fail⁃ Life Sci,2023,315:121331
ure[J]. J Am Soc Nephrol,2021,32(6):1513-1526 [收稿日期] 2024-08-02
[15]COHEN C,MHAIDLY R,CROIZER H,et al. WNT⁃de⁃ (本文编辑:陈汐敏)

