Page 92 - 南京医科大学自然版

南京医科大学学报（自然科学版） 第45卷第5期
·678 · Journal of Nanjing Medical University（Natural Sciences） 2025年5月

·临床研究·

抗 SSA 阳性伴或不伴抗 SSB 阳性对儿童狼疮性肾炎患者的临

床意义

王文琰，车若琛，赵三龙，丁桂霞，赵 非，成学琴 *

南京医科大学附属儿童医院肾脏科，江苏 南京 210008

［摘 要］ 目的：探讨抗SSA阳性伴或不伴抗SSB阳性对狼疮性肾炎患儿的临床意义。方法：回顾性分析2018年1月1日—
2023 年 1 月 1 日在南京医科大学附属儿童医院肾脏科初诊狼疮性肾炎患儿的临床病理资料，85 例狼疮性肾炎患儿入选本研
究，根据自身抗体的检查结果，分为抗SSA阳性伴或不伴抗SSB阳性组（A组，共34例）以及抗SSA和抗SSB均阴性组（B组，共
51 例），A组又分为仅抗SSA阳性组（A1组，22例）和抗SSA及SSB均阳性组（A2组，12例），不存在仅抗SSB阳性情况。比较各
组间临床表现、系统性红斑狼疮疾病活动度评分⁃2000（systemic lupus erythematosus disease activity index 2000，SLEDAI⁃2K）及
病理特点，并随访治疗半年狼疮肾炎的缓解情况。结果：A组、A1组分别与B组相比，临床表现、SLEDAI⁃2K、肾脏病理分型及
半年缓解率差异无统计学意义（P > 0.05）。而A2组患儿皮疹发生率较B组低，差异有统计学意义（P < 0.05），且A2组半年未缓
解率高于B组，差异有统计学意义（P < 0.05）。结论：抗SSB阳性的狼疮性肾炎患儿均伴有抗SSA阳性，抗SSA及SSB均阳性的
狼疮性肾炎患儿，临床上虽然皮疹发生率偏低，但半年肾脏未缓解率较高，可能需要更积极的针对肾脏的治疗。
［关键词］ 抗SSA阳性；抗SSB阳性；儿童；狼疮性肾炎
［中图分类号］ R726.9 ［文献标志码］ A ［文章编号］ 1007⁃4368（2025）05⁃678⁃05
doi：10.7655/NYDXBNSN240970

Significance of anti⁃SSA positive with or without anti⁃SSB positive in children with lupus

nephritis
WANG Wenyan，CHE Ruochen，ZHAO Sanlong，DING Guixia，ZHAO Fei，CHENG Xueqin *
Department of Nephrology，Children’s Hospital of Nanjing Medical University，Nanjing 210008，China

［Abstract］ Objective：To investigate the clinical significance of anti⁃SSA positive with or without anti⁃SSB positive in children with
lupus nephritis. Methods：The clinicopathological data of children with lupus nephritis newly diagnosed in the Nephrology Department
of Nanjing Children’s Hospital from January 1，2018 to January 1，2023 were retrospectively analyzed. Eighty⁃five children with lupus
nephritis were enrolled in this study，including 34 children in the anti⁃SSA positive with or without anti⁃SSB positive group（Group A）
and 51 children in the anti⁃SSA and anti⁃SSB negative group（Group B）. Group A was divided into Group A1（anti⁃SSA positive，22
children）and Group A2（anti ⁃ SSA and anti ⁃ SSB positive，12 children）. The clinical manifestations，SLEDAI ⁃ 2K scores and
pathological features were compared among all groups，and the remission of lupus nephritis after six months of treatment was followed
up. Results：The Group A and Group A1 had no statistical significance compared with the Group B，respectively（P > 0.05）. The
incidence of rash in the Group A2 was lower than that in the Group B，the difference was statistically significant（P < 0.05），and the
non ⁃ remission rate in the Group A2 was higher than that in the Group B，the difference was statistically significant（P < 0.05）.
Conclusion：Children with anti⁃SSB positive lupus nephritis are all accompanied by anti⁃SSA positive，and children with both anti⁃SSA
and anti⁃SSB positive lupus nephritis have a lower incidence of rash clinically，but a higher renal unremission rate for half a year，
which may require more aggressive renal treatment.
［Key words］ anti⁃SSA positive；anti⁃SSB positive；child；lupus nephritis
［J Nanjing Med Univ，2025，45（05）：678⁃682］

［基金项目］ 南京市卫生科技发展专项（YKK22159）
通信作者（Corresponding author），E⁃mail：duoer417@126.com（ORCID：0009⁃0006⁃3919⁃9709）
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