Page 21 - 南京医科大学自然版

第45卷第6期 行浩然，赵海强，鲍天昊. 事件相关电位在抑郁障碍诊疗中的潜力与前景［J］.
2025年6月 南京医科大学学报（自然科学版），2025，45（6）：756-765，809 ·759 ·

表1 P300波幅和潜伏期在抑郁障碍患者中的变化
Table 1 Changes of P300 amplitude and latency in patients with depressive disorders

Study Participants（n） Parameters Antidepressant use Major findings
Van Dinteren MDD：1008； P300，N100 Patients were randomized in a Patients with MDD exhibited significantly
［16］
et al.，2015 HC：336 1∶1∶1 ratio to receive treatment lower P300 amplitudes compared to HC.
with escitalopram，sertraline，or There were no significant differences in
venlafaxine P300 changes among patients treated with
the three different antidepressants，and
P300 was not an effective predictor of treat⁃
ment response
Chen et al.， First⁃episode P3a， Antidepressants acting on the In patients with recurrent MDD，the P3a
［13］
2015 MDD：45；Recur⁃ MMN serotonin system amplitude was significantly reduced and
rent MDD：40； the latency was significantly prolonged
HC：46 compared to HC. Additionally，the MMN
amplitude was significantly reduced in pa⁃
tients with MDD compared to HC
Zhou et al.， MDD：30；HC：30 P300 Five patients were medication ⁃ Patients with MDD exhibited significantly
2018 ［5］ free，while twenty ⁃ five patients reduced P300 amplitudes and prolonged
were receiving antidepressant P300 latencies compared to HC
treatment
Shim et al.， MDD：67；HC：39 P300 Antidepressant treatment Patients with MDD exhibited significantly
2019 ［22］ reduced P300 amplitudes compared to HC
Li et al.， MDD：60；HC：40 P300，MMN， Patients with first ⁃ episode MDD Patients with MDD exhibited significantly
［12］
2020 P50 who were drug⁃naïve reduced P300 and MMN amplitudes and
prolonged P300 and MMN latencies com⁃
pared to HC. Furthermore，the S1 P50 am⁃
plitude was significantly lower in patients
with MDD than in HC，while the S2 P50
amplitude was significantly higher
Santopetro MDD：58 P300 Some patients were medicated， A reduction in P300 amplitude at the first
［15］
et al.，2020 while others were drug⁃naïve visit in patients with MDD was associated
with an increase in overall depressive
symptoms at follow⁃up
Jang et al.， MDD：33；HC：30 P300，N100 Twenty⁃seven patients were drug⁃ Patients with MDD exhibited significantly
2021 ［17］ naïve，while six patients received reduced P300 and N100 amplitudes com⁃
antidepressant treatment pared to HC
White et al.， MDD：60；HC：40 P300，N200 Some patients were medicated， Patients with MDD exhibited significantly
［19］
2021 while others were drug⁃naïve reduced P300 amplitudes compared to HC
Wen et al.， MDD with Self⁃injury： P3a，P3b， Patients with first ⁃ episode MDD Patients with MDD exhibited significantly
2021 ［23］ 18；MDD without Self⁃ N100，N200， who were drug⁃naïve prolonged latencies of P3a，P3b，N100，
injury：21；HC：24 P50 N200，and P50 compared to HC
Santopetro et al.， MDD：80；HC：43 P300 Forty ⁃ four patients were drug ⁃ Patients with MDD exhibited significantly
2021 ［21］ naïve，while thirty ⁃ six patients reduced P300 amplitudes compared to HC
received antidepressant treatment
Fang et al.， MDD：18；HC：20 P300，N200， Some patients were medicated， Patients with MDD in remission exhibited
2022 ［20］ N450 while others were drug⁃naïve significantly increased P300 amplitudes
compared to HC
Jang et al.， MDD：31；HC：31 P300 Patients with first ⁃ episode MDD Patients with MDD exhibited significantly
［14］
2023 who were drug⁃naïve increased P300 amplitudes compared to HC
MMN：mismatch negativity；MDD：major depressive disorder；HC：healthy controls.