Page 70 - 南京医科大学自然版
P. 70

第45卷第7期
               ·968 ·                            南 京    医 科 大 学 学         报                        2025年7月



                                          Combination group             100                 Combination group
                      100
                                          Non⁃combination group                             Non⁃combination group
                       80                                                80
                      (%)  60                                           (%)  60

                      PFS  40                                           OS  40
                           P=0.025                                           P=0.203
                       20                                                20
                           HR=0.625                                          HR=0.694
                        0                                                 0
                             12   24   36   48   60   72                       12   24   36   48   60   72
                 Combination                                      Combination
                        68    31    18    9    5     0     0              68    41    21   12     7    0     0
                    group                                             group
              Non⁃combination                                   Non⁃combination
                        103   50    23    11   3     2     0              103   69    40   18     6    2     0
                    group                                             group
                         0    12    24   36    48    60    72              0    12    24   36    48    60   72
                                    Time(months)                                      Time(months)
                                             图2 联合治疗组与非联合治疗组的生存曲线
                              Figure 2 Survival curves of the combination group and the non⁃combination group


                A                                                  B
                                            Combination group                              Combination group
                          100                                             100
                                            Non⁃combination group                          Non⁃combination group
                           80                                              80
                         (%)  60                                         (%)  60
                         PFS  40                                         OS  40
                              P=0.310                                         P=0.492
                           20                                              20
                              HR=0.754                                        HR=0.745
                           0                                               0
                                12   24  36  48   60  72                        12  24   36  48  60   72
                 Combination                                      Combination
                        42    20    14    9    5     0     0              42    25    17   11     7    0     0
                    group                                             group
              Non⁃combination                                   Non⁃combination
                        62    37    16    10   3     2     0              62    45    29   14     4    2     0
                    group                                             group
                         0    12    24   36    48    60    72              0    12    24   36    48    60   72
                                    Time(months)                                     Time(months)

                C                                                  D
                                           Combination group                                Combination group
                          100                                             100
                                           Non⁃combination group                            Non⁃combination group
                           80                                              80
                         (%)  60                                          (%)  60
                         PFS  40                                          OS  40

                                                                              P=0.305
                           20 P=0.027                                      20
                                                                              HR=0.673
                             HR=0.500
                           0                                                0
                                12   24  36  48   60  72                         12  24  36   48  60  72
                 Combination                                      Combination
                         26   12     5    0     0     0    0              26    16   5      2    0     0     0
                    group                                             group
              Non⁃combination                                   Non⁃combination
                         41   14     8    2     0     0    0              41    24   12     5    3     0     0
                    group                                             group
                         0     12   24    36   48    60    72             0     12   24    36    48    60   72
                                     Time(months)                                    Time(months)
                 A:PFS in the first⁃line treatment subgroup. B:OS in the first⁃line treatment subgroup. C:PFS in the subsequent⁃line treatment subgroup. D:OS in
              the subsequent⁃line treatment subgroup.
                               图3 一线或后线方案治疗患者按是否联合抗血管生成药物治疗分组的生存曲线
              Figure 3  Survival curves of patients receiving first⁃line or subsequent⁃line therapy stratified by the use of anti⁃angiogenic
                       agents
   65   66   67   68   69   70   71   72   73   74   75