Page 73 - 南京医科大学自然版
P. 73
第45卷第7期 高婧婧,宗 丹,徐婧姝,等. 抗血管生成药物联合PD⁃1抑制剂及化疗对晚期鼻咽癌的疗效
2025年7月 与安全性分析[J]. 南京医科大学学报(自然科学版),2025,45(7):963-972 ·971 ·
ble for data collection;HE Xia was responsible for research of immunotherapy combination strategies in cancer[J].
guidance and manuscript review. Cancer Discov,2021,11(6):1368-1397
[参考文献] [13] MA X L,HUANG J W,WU X,et al. Epidermal growth
factor receptor could play a prognostic role to predict the
[1] CHEN Y P,CHAN A T C,LE Q T,et al. Nasopharyngeal
outcome of nasopharyngeal carcinoma:a meta⁃analysis[J].
carcinoma[J]. Lancet(London,England),2019,394
Cancer Biomark,2014,14(4):267-277
(10192):64-80
[14] CHEN L,LIN G X,CHEN K H,et al. VEGF promotes
[2] CHANG E T,YE W M,ZENG Y X,et al. The evolving
migration and invasion by regulating EMT and MMPs in
epidemiology of nasopharyngeal carcinoma[J]. Cancer nasopharyngeal carcinoma[J]. J Cancer,2020,11(24):
Epidemiol Biomark Prev,2021,30(6):1035-1047
7291-7301
[3] CHENG G,DONG H,YANG C,et al. A review on the
[15]CREELAN B C,WANG C,TEER J K,et al. Tumor⁃infil⁃
advances and challenges of immunotherapy for head and
trating lymphocyte treatment for anti ⁃ PD ⁃ 1 ⁃ resistant
neck cancer[J]. Cancer Cell Int,2021,21(1):406 metastatic lung cancer:a phase 1 trial[J]. Nat Med,
[4] YAN L,REN B,HU R,et al. Are PD⁃1 inhibitors effective
2021,27(8):1410-1418
for recurrent/metastatic nasopharyngeal carcinoma? Meta⁃
[16]LORUSSO D,XIANG Y,HASEGAWA K,et al. Pembroli⁃
analysis and systematic review[J]. Front Pharmacol,
zumab or placebo with chemoradiotherapy followed by
2022,13:1095734 pembrolizumab or placebo for newly diagnosed,high⁃risk,
[5] YANG Y P,QU S,LI J G,et al. Camrelizumab versus
locally advanced cervical cancer(ENGOT ⁃ cx11/GOG ⁃
placebo in combination with gemcitabine and cisplatin as 3047/KEYNOTE ⁃ A18):a randomised,double ⁃ blind,
first⁃line treatment for recurrent or metastatic nasopharyn⁃ phase 3 clinical trial[J]. Lancet,2024,403(10434):
geal carcinoma(CAPTAIN⁃1st):a multicentre,randomised,
1341-1350
double⁃blind,phase 3 trial[J]. Lancet Oncol,2021,22 [17] JANJIGIAN Y Y,KAWAZOE A,BAI Y X,et al. Pembro⁃
(8):1162-1174
lizumab plus trastuzumab and chemotherapy for HER2 ⁃
[6] MAI H Q,CHEN Q Y,CHEN D P,et al. Toripalimab plus positive gastric or gastro⁃oesophageal junction adenocarci⁃
chemotherapy for recurrent or metastatic nasopharyngeal
noma:interim analyses from the phase 3 KEYNOTE⁃811
carcinoma:the JUPITER⁃02 randomized clinical trial[J]. randomised placebo ⁃ controlled trial[J]. Lancet,2023,
JAMA,2023,330(20):1961-1970
402(10418):2197-2208
[7] YANG Y P,PAN J J,WANG H,et al. Tislelizumab plus [18]CHENG D A,HU J,WU X Y,et al. PD⁃1 blockade com⁃
chemotherapy as first⁃line treatment for recurrent or meta⁃ bined with gemcitabine plus nab⁃paclitaxel is superior to
static nasopharyngeal cancer:a multicenter phase 3 trial chemotherapy alone in the management of unresectable
(RATIONALE ⁃ 309)[J]. Cancer Cell,2023,41(6): stage Ⅲ/Ⅳ pancreatic cancer:a retrospective real⁃world
1061-1072 study[J]. Front Oncol,2023,13:1281545
[8] RAHMA O E,HODI F S. The intersection between tumor [19] YOU R,ZOU X,DING X,et al. Gemcitabine combined
angiogenesis and immune suppression[J]. Clin Cancer with apatinib and toripalimab in recurrent or metastatic
Res,2019,25(18):5449-5457 nasopharyngeal carcinoma[J]. Med,2022,3(10):664-
[9] WEGMANN F,PETRI B,KHANDOGA A G,et al. ESAM 681
supports neutrophil extravasation,activation of Rho,and [20] HUANG H,YAO Y,DENG X,et al. Characteristics of
VEGF ⁃ induced vascular permeability[J]. J Exp Med, immunotherapy trials for nasopharyngeal carcinoma over
2006,203(7):1671-1677 a 15⁃year period[J]. Front Immunol,2023,14:1195659
[10] HARIMOTO H,SHIMIZU M,NAKAGAWA Y,et al. [21]LIANG H,JIANG Y F,LIU G Y,et al. Camrelizumab and
+
Inactivation of tumor⁃specific CD8 CTLs by tumor⁃infil⁃ apatinib plus induction chemotherapy and concurrent
trating tolerogenic dendritic cells[J]. Immunol Cell Biol, chemoradiotherapy in stage N3 nasopharyngeal carcino⁃
2013,91(9):545-555 ma:a phase 2 clinical trial[J]. Nat Commun,2024,15
[11]ZHANG X Y,ZENG L,LI Y Z,et al. Anlotinib combined (1):1029
with PD⁃1 blockade for the treatment of lung cancer:a real⁃ [22] YUAN L,JIA G D,LV X F,et al. Camrelizumab com⁃
world retrospective study in China[J]. Cancer Immunol bined with apatinib in patients with first⁃line platinum⁃
Immunother,2021,70(9):2517-2528 resistant or PD⁃1 inhibitor resistant recurrent/metastatic
[12]YAP T A,PARKES E E,PENG W Y,et al. Development nasopharyngeal carcinoma:a single⁃arm,phase 2 trial[J].

