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               ·982 ·                            南 京    医 科 大 学 学         报                        2025年7月


              析,有效提升对生存评估的准确性。                                  [3] KOH J S,JOO M K,PARK J J,et al. Characteristics of
                  本研究也存在一定的局限性。第一,单中心、                               proximal early gastric cancer differentiating distal early⁃
              回顾性研究可能导致不可避免的偏倚,尽管进行了                                 gastric cancer[J]. PLoS One,2019,14(9):e0223284
              PSM 分析以最小化偏差,但混杂效应无法完全消                           [4] CHU Y N,YU Y N,JING X,et al. Feasibility of endoscopic
                                                                     treatment and predictors of lymph node metastasis inearly
              除。第二,研究纳入的 ESD 组(393 例)和手术组
                                                                     gastric cancer[J]. World J Gastroenterol,2019,25(35):
             (169 例)的样本量存在差异,这会对结果造成一定
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              的偏差。第三,由于患者中存在部分失访,ESD及外                          [5] AJANI J A,D’AMICO T A,BENTREM D J,et al. Esoph⁃
              科手术治疗AEGJ患者的疾病进展和长期预后的临                                ageal and esophagogastric junction cancers,version
              床价值仍有不确定性。第四,手术组患者未根据关                                 2.2023,NCCN clinical practice guidelines in oncology[J].
              键变量(如手术方式的选择、是否联合食管切除术                                 J Natl Compr Canc Netw,2023,21(4):393-422
              等)进行更细致的亚组分析,这些因素可能对并发                            [6] LIU K,FENG F,CHEN X Z,et al. Comparison between
              症发生率及生存结局产生潜在影响。                                       gastric and esophageal classification system amongadeno⁃
                                                                     carcinomas of esophagogastric junction according to
                  综上所述,本研究发现早期 SiewertⅡ型 AEGJ
                                                                     AJCC 8th edition:aretrospective observational study from
              患者接受ESD或手术治疗的长期生存结局相似,对                                two high⁃volume institutions in China[J]. Gastric Cancer,
              于符合内镜切除绝对或扩展标准的病例,ESD 可替
                                                                     2019,22(3):506-517
              代外科手术实现等效预后。                                      [7] GREALLY M,AGARWAL R,ILSON D H. Optimal man⁃
                  利益冲突声明:                                            agement of gastroesophageal junction cancer[J]. Cancer,
                  所有作者声明不存在任何利益冲突。                                   2019,125(12):1990-2001
                  Conflict of Interests:                        [8] TAKADA K,YABUUCHI Y,YAMAMOTO Y,et al. Pre⁃
                  The authors have declared that no competing interest exists.  dicting the depth of superficial adenocarcinoma of the
                  作者贡献声明:                                            esophagogastricjunction[J]. J Gastroenterol Hepatol,
                  郁馨负责研究概念和设计,数据分析与解释,稿件起                            2022,37(2):363-370
              草。杨若云负责数据提取,设计并排序图表,研究质量评                         [9] JIA P F,LI Y R,WANG L Y,et al. Radiomics in esopha⁃
              估。周晓颖和陈涵负责设计并排序图表,研究质量评估。张                             gogastric junction cancer:a scoping review of current sta⁃
              国新负责对稿件重要知识产权内容的审稿,获得资金和研究                             tusand advances[J]. Eur J Radiol,2024,177:111577
              监督。所有作者均对文章作出贡献并批准了提交的版本。                         [10]Japanese Gastric Cancer Association. Japanese gastric
                  Author’s Contribution:                             cancer treatment guidelines 2021(6th edition)[J]. Gas⁃
                  YU Xin was responsible for study conception and design,  tric Cancer,2023,26(1):1-25
              performed data analysis and interpretation,and drafted the man⁃  [11]ZHENG Y H,ZHAO E H. Recent advances in multidisci⁃
              uscript. YANG Ruoyun conducted data extraction,design and  plinary therapy for adenocarcinoma of the esophagusand
                                                                     esophagogastric junction[J]. World J Gastroenterol,
              arranged the charts,and contributed to study quality assess⁃
              ment. ZHOU Xiaoying and CHEN Han participated in chart de⁃  2022,28(31):4299-4309
              sign and arrangement as well as study quality assessment;  [12]MATSUMOTO C,IWATSUKI M,MORINAGA T,et al.
              ZHANG Guoxin provided critical review of the manuscript for  Long⁃term survival after multidisciplinary treatments for
                                                                     advancedesophagogastric junction cancer[J]. Int Cancer
              important intellectual content,secured funding,and supervised
                                                                     Conf J,2021,10(3):207-211
              the study. All authors have made substantial contributions to
                                                                [13]LUMISH M A,WALCH H,MARON S B,et al. Clinical
              this work and approved the final version to be published.
                                                                     and molecular characteristics of early⁃onset vs. average⁃
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