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第45卷第7期 王 潇,王一帆,孙龙虎,等. 奶酪摄入与健康寿命终止风险的关联及其代谢机制研究[J].
2025年7月 南京医科大学学报(自然科学版),2025,45(7):991-1000 ·995 ·
(续表1)
Characteristics HST(n=93 214) Control(n=279 642) P
Moderate 32 533(34.90) 98 489(35.22)
Heavy 41 561(44.59) 132 407(47.35)
IPAQ activity group[n(%)] <0.001
Low 14 176(15.21) 37 965(13.58)
Moderate 29 531(31.68) 93 131(33.30)
High 29 581(31.73) 94 503(33.79)
Healthy diet[n(%)] 58 070(62.30) 181 581(64.93) <0.001
Carbohydrate intake[n(%)] <0.001
Low 11 400(12.23) 38 796(13.87)
Moderate 11 680(12.53) 40 836(14.60)
High 12 292(13.19) 41 873(14.97)
Protein intake[n(%)] <0.001
Low 11 354(12.18) 39 131(13.99)
Moderate 11 745(12.60) 41 181(14.73)
High 12 273(13.17) 41 193(14.73)
Fat intake[n(%)] <0.001
Low 11 551(12.39) 39 537(14.14)
Moderate 11 713(12.57) 41 077(14.69)
High 12 108(12.99) 40 891(14.62)
Unknown 57 842(62.05) 158 137(56.55)
Fiber intake[n(%)] <0.001
Low 11 495(12.33) 38 406(13.73)
Moderate 11 654(12.50) 40 740(14.57)
High 12 223(13.11) 42 359(15.15)
Aspirin/ibuprofen used[n(%)] 23 375(25.08) 63 393(22.67) <0.001
CLM used[n(%)] 6 272(6.73) 14 388(5.15) <0.001
Have family cancer[n(%)] 34 667(37.19) 100 693(36.01) <0.001
Have family CCVD[n(%)] 54 753(58.74) 160 357(57.34) <0.001
HST:healthspan terminated;BMI:body mass index;Townsend:Townsend deprivation index;IPAQ:international physical activity questionnaire;
CCVD:Cardiovascular and cerebrovascular diseases;CLM:Cholesterol lowering medication. The Mann⁃Whitney test was used to calculate whether the
distribution of continuous variables was statistically different between the two groups. The Chi⁃squared test was used to calculate whether the distribu⁃
tion of categorical variables was statistically different between the two groups.
表2 奶酪摄入量和HST风险的关联
Table 2 Association of cheese intake with HST
Crude model Fully adjusted model
Cheese intake
OR(95%CI) Ptrend OR(95%CI) Ptrend
Never Ref. - Ref. -
Low frequency 0.94(0.90-0.99) 0.015 0.98(0.94-1.03) 0.431
Moderate frequency 0.88(0.84-0.92) <0.001 0.95(0.90-0.99) 0.026
High frequency 0.83(0.79-0.87) <0.001 0.93(0.89-0.98) <0.001
<0.001 <0.001
Ptrend
OR:odds ratio;CI:confidence interval;Ptrend:P value for trend. Conditional logistic regression was used to estimate the odds ratios and corresponding
95% confidence intervals of cheese intake related to HST. We established two model. Crude model:unadjusted model. Fully adjusted model:adjusted
for BMI,townsend,ethnic,education,smoking status,alcohol intake,IPAQ activity group,family cancer,family CCVD,aspirin/ibuprofen used,
cholesterol lowering medication used,healthy diet.

