Page 118 - 《南京医科大学学报(自然科学版)》2025年第9期
P. 118

第45卷第9期
               ·1330 ·                           南 京    医 科 大 学 学         报                        2025年9月


                                       表2 NAFLD相关影响因素的二元多因素Logistic回归分析
                            Table 2 Multifactorial logistic regression analysis of NAFLD⁃related influencing factors
                          Index                 B         SE        Wald χ 2      P            OR(95%CI)
                  AI                           0.743     0.141      27.701      <0.001      2.103(1.595-2.774)
                  Sex
                   Male                                                                     1.000(Ref.)
                   Female                     -0.035     0.317      00.012       0.913      0.966(0.519-1.797)
                  Age                         -0.025     0.015      02.850       0.091      0.975(0.947-1.004)
                  BMI                          0.356     0.090      15.674      <0.001      1.428(1.197-1.703)
                  SBP                          0.001     0.009      00.016       0.899      1.001(0.983-1.020)
                  AST                          0.071     0.016      19.987      <0.001      1.073(1.041-1.107)
                  FBG                          0.783     0.186      17.665      <0.001      2.188(1.519-3.152)
                  Uric acid                    0.003     0.002      02.617       0.106      1.003(0.999-1.007)
                  TG                          -0.055     0.035      02.549       0.110      0.946(0.884-1.013)
                  LDL⁃C                       -0.070     0.079      00.775       0.379      0.932(0.798-1.090)
                  baPWV                        0.001     0.001      06.323       0.012      1.001(1.000-1.003)
                  eGFR                         0.019     0.011      02.760       0.097      1.019(0.997-1.042)
                  Frequency of regular exercise
                   <1 time/week                                                             1.000(Ref.)
                   ≥1 time/week               -0.492     0.307      02.566       0.109      0.611(0.335-1.116)
                  Body weight condition
                   Normal weight                                    01.334       0.513      1.000(Ref.)
                   Over weight                 0.399     0.370      01.164       0.281      1.490(0.722-3.077)
                   Obesity                     0.370     0.817      00.206       0.650      1.448(0.292-7.177)



                                  表3 不同模型中AI与NAFLD相关关系的二元多因素Logistic回归分析
                   Table 3 Multifactorial logistic regression analysis of the association between AI and NAFLD in different models

                                Model 1               Model 2               Model 3              Model 4
                 Index
                           OR(95%CI)      P       OR(95%CI)      P     OR(95%CI)      P      OR(95%CI)     P
              AI        02.335(2.009-2.713) <0.001 02.216(1.899-2.586) <0.001 1.850(1.548-2.210) <0.001 1.846(1.541-2.121) <0.001
              AI(quartile)
                Q1            Ref.                   Ref.                 Ref.                  Ref.
                Q2      02.304(1.158-4.580) 0.017 02.150(1.073-4.308) 0.031 1.385(0.637-3.013) 0.411 1.449(0.662-3.171) 0.353
                Q3      05.453(2.880-10.325)<0.001 04.775(2.949-9.144) <0.001 2.296(1.103-4.777) 0.026 2.294(1.097-4.795) 0.027
                Q4      16.893(9.071-31.460)<0.001 13.860(7.313-26.270)<0.001 6.180(3.035-12.584)<0.001 6.169(3.006-12.661)<0.001
              P              <0.001                 <0.001               <0.001               <0.001
                 Model 1 did not adjust for confounding factors;Model 2 adjusted for age and gender;Model 3 adjusted for age,gender,BMI,AST,and fasting blood
              glucose;Model 4 adjusted for age,gender,BMI,AST,fasting blood glucose,smoking status,and exercise status. The arterial sclerosis index(AI)was di⁃
              vided into four equal groups:the first group(Q1,AI≤2.23,n=213),the second group(Q2,AI≤2.24-2.93,n=215),the third group(Q3,AI≤2.94-3.90,
              n=214),and the fourth group(Q4,AI≥3.91,n=214).

              P < 0.001),也高于传统血脂指标 TC(AUC=0.576,
                                                                3  讨 论
              95% CI=0.532~0.621,P=0.001;DeLong 检 验 ,P <
              0.001)、TG(AUC=0.735,95% CI=0.696~0.774,P <             本研究的856例日本体检人群发生脂肪肝209例,
              0.001;DeLong 检验,P=0.013)、LDL⁃C(AUC=0.639,         NAFLD 的发生率为 24.42%,体重正常、超重和肥胖

              95% CI=0.597~0.681,P < 0.001;DeLong 检 验 ,P <      者NAFLD患病率分别为11.17%、48.20%和83.72%,
              0.001),提示AI具有更优异的预测能力(图2)。                        BMI与NAFLD呈正相关,这与现有的研究一致。窦紫
   113   114   115   116   117   118   119   120   121   122   123