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第46卷第1期 杨明哲,陈仁杰. 基于cfDNA多组学模型进行头颈部鳞状细胞癌早期诊断的研
2026年1月 究进展[J]. 南京医科大学学报(自然科学版),2026,46(1):21-30 · 29 ·
(1):430 HPV⁃negative head and neck squamous cell carcinomas
[16] CARVALHO A L,HENRIQUE R,JERONIMO C,et al. [J]. Clin Cancer Res,2015,21(3):632-641
Detection of promoter hypermethylation in salivary rinses [30]LECHNER M,SCHARTINGER V H,STEELE C D,et al.
as a biomarker for head and neck squamous cell carcinoma Somatostatin receptor 2 expression in nasopharyngeal
surveillance[J]. Clin Cancer Res,2011,17(14):4782- cancer is induced by Epstein Barr virus infection:impact
4789 on prognosis,imaging and therapy[J]. Nat Commun,
[17]CHEN K Z,ZHANG J B,GUAN T,et al. Comparison of 2021,12(1):117
plasma to tissue DNA mutations in surgical patients with [31]LEEMANS C R,SNIJDERS P J F,BRAKENHOFF R H.
non⁃small cell lung cancer[J]. J Thorac Cardiovasc Surg, The molecular landscape of head and neck cancer[J].
2017,154(3):1123-1131 Nat Rev Cancer,2018,18(5):269-282
[18] AGRAWAL N,FREDERICK M J,PICKERING C R,et [32]GILLISON M L,KOCH W M,CAPONE R B,et al. Evi⁃
al. Exome sequencing of head and neck squamous cell dence for a causal association between human papilloma⁃
carcinoma reveals inactivating mutations in NOTCH1[J]. virus and a subset of head and neck cancers[J]. J Natl
Science,2011,333(6046):1154-1157 Cancer Inst,2000,92(9):709-720
[19] RAJA R,KUZIORA M,BROHAWN P Z,et al. Early [33]FERRIS R L,BLUMENSCHEIN G Jr,FAYETTE J,et al.
reduction in ctDNA predicts survival in patients with Nivolumab for recurrent squamous⁃cell carcinoma of the
lung and bladder cancer treated with durvalumab[J]. head and neck[J]. N Engl J Med,2016,375(19):1856-
Clin Cancer Res,2018,24(24):6212-6222 1867
[20]CABEL L,RIVA F,SERVOIS V,et al. Circulating tumor [34]CHAUDHARY K,POIRION O B,LU L Q,et al. Deep
DNA changes for early monitoring of anti⁃PD1 immuno⁃ learning⁃based multi⁃omics integration robustly predicts
therapy:a proof⁃of⁃concept study[J]. Ann Oncol,2017, survival in liver cancer[J]. Clin Cancer Res,2018,24
28(8):1996-2001 (6):1248-1259
[21] HASIN Y,SELDIN M,LUSIS A. Multi⁃omics approaches [35]BARABÁSI A L,GULBAHCE N,LOSCALZO J. Network
to disease[J]. Genome Biol,2017,18(1):83 medicine:a network⁃based approach to human disease[J].
[22]HUANG S J,CHAUDHARY K,GARMIRE L X. More is Nat Rev Genet,2010,12(1):56-68
better:recent progress in multi ⁃ omics data integration [36]LIU X H,WANG G R,ZHONG N N,et al. Multi⁃omics in
methods[J]. Front Genet,2017,8:84 immunotherapy research for HNSCC:present situation
[23]KARCZEWSKI K J,SNYDER M P. Integrative omics for and future perspectives[J]. NPJ Precis Oncol,2025,9
health and disease[J]. Nat Rev Genet,2018,19(5):299- (1):93
310 [37] BOLGER A M,LOHSE M,USADEL B. Trimmomatic:a
[24]RITCHIE M D,HOLZINGER E R,LI R W,et al. Methods flexible trimmer for illumina sequence data[J]. Bioinfor⁃
of integrating data to uncover genotype⁃phenotype inter⁃ matics,2014,30(15):2114-2120
actions[J]. Nat Rev Genet,2015,16(2):85-97 [38]HO T K. Random decision forests[C]//Proceedings of 3rd
[25]BOYLE A P,HONG E L,HARIHARAN M,et al. Annota⁃ international conference on document analysis and recog⁃
tion of functional variation in personal genomes using nition. Washinton DC:IEEE,2002:278-282
RegulomeDB[J]. Genome Res,2012,22(9):1790-1797 [39]CORTES C,VAPNIK V. Support ⁃ vector networks[J].
[26]HUTTER C,ZENKLUSEN J C. The cancer genome atlas: Mach Learn,1995,20(3):273-297
creating lasting value beyond its data[J]. Cell,2018,173 [40]CHEN T Q,GUESTRIN C. XGBoost:a scalable tree boos⁃
(2):283-285 ting system[C]//Proceedings of the 22nd ACM SIGKDD
[27] RAIHAN F R,ABDULRAZAK L F,RAHMAN M A, international conference on knowledge discovery and data
et al. StackTHP:a stacking ensemble model for accurate mining. New York:ACM,2016:785-794
prediction of tumor⁃homing peptides in cancer therapy[J]. [41]KE G L,MENG Q,FINLEY T,et al. LightGBM:a highly
Comput Biol Med,2025,189:109958 efficient gradient boosting decision tree[C]//Proceedings
[28] STRANSKY N,EGLOFF A M,TWARD A D,et al. The of the 31st international conference on neural information
mutational landscape of head and neck squamous cell processing systems. New York:Curran Associates Inc.,
carcinoma[J]. Science,2011,333(6046):1157-1160 2017:6000-6010
[29]SEIWERT T Y,ZUO Z X,KECK M K,et al. Integrative [42] LECUN Y,BENGIO Y,HINTON G. Deep learning[J].
and comparative genomic analysis of HPV ⁃ positive and Nature,2015,521(7553):436-444

