Page 85 - 《南京医科大学学报》自然科学版2026年第2期
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第46卷第2期                           南京医科大学学报(自然科学版)
                  2026年2月                   Journal of Nanjing Medical University(Natural Sciences)     ·241 ·


               ·临床研究·

                腰椎零回波时间成像中采样点数对图像质量影响的探讨



                孙   仪 ,徐露露 ,吴仆射 ,邹月芬           1*
                      1
                                       2
                              1
                南京医科大学第一附属医院放射科,江苏 南京                  210029;通用电气医疗,北京        100176
                1                                            2

               [摘   要] 目的:探讨不同采样点数(number of readout points,Nread)对腰椎零回波时间(zero echo time,ZTE)成像质量的影响,
                并确定最优的 Nread。方法:招募 16 例健康志愿者,分别采用 128、144 和 160 3 种 Nread进行腰椎冠状位 ZTE 扫描,获得 Nread⁃128、
                Nread⁃144和Nread⁃160 3组图像。在各组图像中分别测量皮质骨、肌肉及松质骨区域的信号强度,并以皮下脂肪标准差作为噪声,
                计算信噪比(signal⁃to⁃noise ratio,SNR)和对比噪声比(contrast⁃to⁃noise ratio,CNR)。由2名观察者采用4分法,从皮质骨描绘、
                解剖结构清晰度、感知图像噪声及总体图像质量4个方面对3组图像进行主观评价,并采用加权Kappa检验评估观察者间评分
                的一致性。SNR和CNR的比较采用重复测量方差分析,图像质量主观评分的比较采用Friedman检验,事后分析均采用Bonfer⁃
                roni法。结果:在所有测量区域(皮质骨、肌肉、松质骨)的SNR及组织间(皮质⁃肌肉、皮质⁃松质)CNR方面,Nread⁃160>Nread⁃144>
                Nread⁃128(P 均< 0.001)。在主观评价方面,Nread⁃160 组明显高于 Nread⁃128 组(P < 0.001),而与 Nread⁃144 组间差异无统计学意义
               (P > 0.05)。结论:在腰椎ZTE成像中,增加Nread有助于提升图像质量。Nread⁃144在提供较高SNR与CNR的同时,其主观图像质量
                评分与Nread⁃160相当。综合考虑扫描时间与图像质量,推荐将144作为腰椎ZTE成像中的最优Nread。
               [关键词] 磁共振成像;腰椎;零回波时间成像;骨皮质;图像质量
               [中图分类号] R445.2                   [文献标志码] A                       [文章编号] 1007⁃4368(2026)02⁃241⁃07
                doi:10.7655/NYDXBNSN251199


                Exploration on the impact of the number of readout points on image quality in zeroecho
                time imaging of the lumbar spine

                      1        1         2           1*
                SUN Yi ,XU Lulu ,WU Pushe ,ZOU Yuefen
                Department of Radiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;GE
                1                                                                                            2
                Healthcare,Beijing 100176,China


               [Abstract] Objective:To investigate the impact of different numbers of readout points(Nread)on image quality in zero echo time
               (ZTE)imaging of the lumbar spine,and to determine the optimal N read. Methods:Sixteen healthy volunteers were recruited and
                underwent coronal ZTE scans of the lumbar spine with three different N read(128,144,and 160),to obtain three sets of images(Nread⁃128,
                Nread⁃144,and Nread⁃160). The signal intensity of the cortical bone,muscle,and cancellous bone was measured in each set,and the
                standard deviation of subcutaneous fat was defined as noise to calculate the signal⁃to⁃noise ratio(SNR)and contrast⁃to⁃noise ratio
               (CNR). Two observers subjectively evaluated the three sets of images using a 4⁃point scale across four aspects:cortical bone depiction,
                anatomical structure clarity,perceived image noise,and overall image quality. Inter⁃observer agreement was assessed using weighted
                Kappa statistics. Repeated ⁃ measures ANOVA was used to compare SNR and CNR,and the Friedman test was used to compare
                subjective image quality scores,with Bonferroni correction applied for post⁃hoc analyses. Results:For the SNR in all measured regions
               (cortical bone,muscle,and cancellous bone)and the CNR between tissues(cortical bone⁃muscle,cortical⁃cancellous bone),the results
                consistently showed N read⁃160>Nread⁃144>Nread⁃128(P < 0.001). In terms of subjective evaluation,the scores for the N read⁃160 set were
                significantly higher than those for the N read⁃128 set(P < 0.001),while the difference between the N read⁃160 set and the Nread⁃144 set was
                not statistically significant(P > 0.05). Conclusion:In ZTE scanning of the lumbar spine,increasing Nread helps improve image quality.
                Nread⁃144 provides high SNR and CNR,and its subjective image quality scores are comparable to those of N read⁃160. Considering both
                scanning time and image quality,144 is recommended as the optimal N readfor ZTE imaging of the lumbar spine.
               [Key words] magnetic resonance imaging;lumbar spine;zero echo time imaging;cortical bone;image quality
                                                                          [J Nanjing Med Univ,2026,46(02):241⁃246,261]
               [基金项目] 国家自然科学基金(81701652)
                通信作者(Corresponding author),E⁃mail:zou_yf@163.com(ORCID:0000⁃0002⁃2645⁃1454)
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