Page 44 - 《南京医科大学学报（自然科学版）》2026年第3期

第46卷第3期
·352 · 南 京 医 科 大 学 学 报 2026年3月

implementation，provide guidance for thesis revision and offer ［12］JUNG S M，DOXSEY W G，LE J，et al. In vivo isotope trac⁃
financial support. ing reveals the versatility of glucose as a brown adipose tis⁃
［参考文献］ sue substrate［J］. Cell Rep，2021，36（4）：109459
［13］BAVIS M M，NICHOLAS A M，TOBIN A J，et al. The
［1］ SU Z G，ZHOU Y H，HAN X K，et al. Symptom burden in breast cancer microenvironment and lipoprotein lipase：
advanced breast cancer patients and its association be⁃
another negative Notch for a beneficial enzyme?［J］.
tween death anxiety and psychological distress［J］. Chin J
FEBS Open Bio，2023，13（4）：586-596
Cancer Res，2022，34（3）：298-308
［14］JIAO Y，ZHANG T，LIU M，et al. Exosomal PGE2 from
［2］ LI C Z，TAO Y J，CHEN Y N，et al. Development of a me⁃
M2 macrophages inhibits neutrophil recruitment and NET
tabolism ⁃ related signature for predicting prognosis，im⁃
formation through lipid mediator class switching in sep⁃
mune infiltration and immunotherapy response in breast
sis［J］. J Biomed Sci，2023，30（1）：62
cancer［J］. Am J Cancer Res，2022，12（12）：5440-5461
［15］GUO Z Y，XU J H，HUANG S Z，et al. Abrogation of graft
［3］ WANG M L，FENG R F，CHEN Z H，et al. Identification
ischemia⁃reperfusion injury in ischemia⁃free liver trans⁃
of cancer⁃associated fibroblast subtype of triple⁃negative
plantation［J］. Clin Transl Med，2022，12（4）：e546
breast cancer［J］. J Oncol，2022，2022：6452636
［16］DECKING S M，BRUSS C，BABL N，et al. LDHB overex⁃
［4］ CHEN X，ZHANG J Z，LEI X H，et al. CD1C is associat⁃
pression can partially overcome T cell inhibition by lactic
ed with breast cancer prognosis and immune infiltrates［J］.
acid［J］. Int J Mol Sci，2022，23（11）：5970
BMC Cancer，2023，23（1）：129
［17］DUBEY S，GHOSH S，GOSWAMI D，et al. Immunometa⁃
［5］ NI Y C，JIANG M N，WU Y X，et al. Anoikis ⁃ related bolic attributes and mitochondria⁃associated signaling of
CTNND1 is associated with immuno ⁃ suppressive tumor tumor ⁃ associated macrophages in tumor microenviron⁃
microenvironment and predicts unfavorable immunothera⁃ ment modulate cancer progression［J］. Biochem Pharma⁃
peutic outcome in non⁃small cell lung cancer［J］. J Can⁃
col，2023，208：115369
cer，2024，15（2）：317-331
［18］LAI Y M，ZHAO S Y，CHEN B F，et al. Iron controls T
［6］ ZHAO Y，WENG Z Y，ZHOU X，et al. Mesenchymal stro⁃ helper cell pathogenicity by promoting glucose metabo⁃
mal cells promote the drug resistance of gastrointestinal lism in autoimmune myopathy［J］. Clin Transl Med，
stromal tumors by activating the PI3K⁃AKT pathway via 2022，12（8）：e999

TGF⁃β2［J］. J Transl Med，2023，21（1）：219 ［19］SHIRAKAWA K，ENDO J，KATAOKA M，et al. IL（inter⁃
［7］ ANDREUZZI E，FEJZA A，POLANO M，et al. Colorectal leukin）⁃10⁃STAT3⁃galectin⁃3 axis is essential for osteo⁃
cancer development is affected by the ECM molecule pontin⁃producing reparative macrophage polarization after
EMILIN ⁃ 2 hinging on macrophage polarization via the myocardial infarction［J］. Circulation，2018，138（18）：
TLR⁃4/MyD88 pathway［J］. J Exp Clin Cancer Res，2022， 2021-2035
41（1）：60 ［20］JOHNSON D E，O’KEEFE R A，GRANDIS J R. Targeting
［8］ LI R，ZHOU Y M，LIU Y J，et al. Asymmetric，amphiphilic the IL ⁃ 6/JAK/STAT3 signalling axis in cancer［J］. Nat
RGD conjugated phthalocyanine for targeted photodynamic Rev Clin Oncol，2018，15（4）：234-248
therapy of triple negative breast cancer［J］. Signal Trans⁃ ［21］MIAO X L，LIU C，JIANG Y C，et al. BET protein inhibi⁃
duct Target Ther，2022，7（1）：64 tion evidently enhances sensitivity to PI3K/mTOR dual in⁃
［9］ WANG F K，MA S S，CHEN P P，et al. Imaging the meta⁃ hibition in intrahepatic cholangiocarcinoma［J］. Cell
bolic reprograming of fatty acid synthesis pathway Death Dis，2021，12（11）：1020
enables new diagnostic and therapeutic opportunity for ［22］CHEN H J，HUANG S，NIU P G，et al. Cardamonin sup⁃
breast cancer［J］. Cancer Cell Int，2023，23（1）：83 presses pro⁃tumor function of macrophages by decreasing
［10］SCHOORS S，DE BOCK K，CANTELMO A R，et al. Par⁃ M2 polarization on ovarian cancer cells via mTOR inhibi⁃
tial and transient reduction of glycolysis by PFKFB3 tion［J］. Mol Ther Oncolytics，2022，26：175-188
blockade reduces pathological angiogenesis［J］. Cell ［23］GU Y R，HUANG Z X，LI X Y，et al. Serum HBV prege⁃
Metab，2014，19（1）：37-48 nomic RNA exhibited opposite associations with NK dim
［11］DE PAZ LINARES G A，OPPERMAN R M，MAJUMDER and NKbright cell immunity in treatment ⁃ naïve chronic
M，et al. Prostaglandin E2 receptor 4（EP4）as a therapeu⁃ hepatitis B patients［J］. Biosci Rep，2021，41（7）：
tic target to impede breast cancer⁃associated angiogenesis BSR20210600
and lymphangiogenesis［J］. Cancers（Basel），2021，13 ［24］LI X L，ZHU X X，DIBA P，et al. Tumor⁃derived cyclooxy⁃
（5）：942 genase⁃2 fuels hypothalamic inflammation［J］. Brain Be⁃