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表2 体力活动水平、是否达到WHO推荐中高强度活动量及静坐时间与月经周期异常的Logistic回归分析
Table 2 Logistic regression analysis of physical activity level,achievement of WHO⁃recommended MVPA,sedentary time,
and abnormal menstrual cycle
Model 1 Model 2 a Model 3 b
Variable
OR(95% CI) P OR(95% CI) P OR(95% CI) P
Physical activity level
Low Ref Ref Ref
Middle 0.51(0.39-0.67) <0.001 0.59(0.44-0.79) <0.001 0.60(0.44- 0.81) <0.001
High 0.49(0.35-0.70) <0.001 0.53(0.36-0.76) <0.001 0.54(0.37- 0.79) <0.010
Recommended MVPA
No Ref Ref Ref
Yes 0.63(0.48- 0.82) <0.001 0.63(0.47- 0.83) <0.010 0.64(0.48- 0.85) <0.010
Daily sedentary time 1.01(0.97-1.05) 0.516 1.02(0.98-1.07) 0.300 1.02(0.98- 1.07) <0.300
a:Adjusted for age,education level,age at menarche,hair loss,dietary habits,family history of menstrual disorders,DASS⁃21 score,PSQI score. b:
Further adjusted for acne,BMI. OR:odds ratio;CI:confidence interval;MVPA:moderate⁃to⁃vigorous physical activity.
A B
1.6 1.6
P for non⁃linear association < 0.05 P for non⁃linear association=0.197
P for overall < 0.001 P for overall < 0.001
(95%CI) 1.2 (95%CI) 1.2
1.0
1.0
OR 0.8 OR 0.8
0.4 0.4
0 600 2 000 4 000 6 000 0 5 7.5 10
Total volume of physical activity(MET⁃min/week) Daily sedentary time(h)
A:Dose ⁃ response relationship between weekly physical activity metabolic equivalents and irregular menstrual cycles. B:Dose ⁃ response
relationship between daily sedentary time and irregular menstrual cycles.
图1 体力活动水平及静坐时间与月经周期异常的非线性关联
Figure 1 The nonlinear association of physical activity and daily sedentary time with irregular menstrual cycles
35 岁人群中,保护效应同样显著,且年龄越大保护
Variable Count Percent P for interaction
Overall 1 246 100 效 应 越 强(OR=0.54,95% CI:0.32~0.92;OR=0.21,
Age 0.030 95%CI:0.05~0.95)。未发现保护效应存在显著的
18-20 276 22.2
2
21-24 430 34.5 BMI差异(交互作用P=0.602)。在BMI<18.5 kg/m 的
25-34 466 37.4
人群中,OR=0.65(95%CI:0.33~1.27),在BMI为18.5~
≥35 74 5.9
2
BMI 0.602 25.0 kg/m 的人群中,OR=0.62(95%CI:0.44~0.87),
<18.5 229 18.4
在 BMI≥25.0 kg/m 的 人 群 中 ,OR=0.19(95% CI:
2
18.5⁃25.0 954 76.6
≥25.0 63 5.1 0.03~1.29)。同样,是否有MD/PCOS/POF家族史,保
FH+ 0.364
No 1 046 83.9 护效应差异无统计学意义(交互作用P值=0.364)。
Yes 200 16.1
3 讨 论
0.5 1 2
Estimates were derived from logistic models. FH+,family history of
本研究发现中等体力活动水平或高等体力活
menstrual disorders(MD)/polycystic ovary syndrome(PCOS)/premature
动水平与更低的月经周期异常风险相关,达到WHO
ovarian failure(POF).
图2 是否达到WHO推荐中高强度活动量标准与月经周期 推荐的MVPA活动量标准与更低的月经周期异常风
异常的亚组分析 险相关。静坐时间与月经周期异常无统计学关
Figure 2 Subgroup analysis of the association of recom ⁃ 联。这表明体力活动的总量可能是影响月经周期
meded MVPA with irregular menstrual cycles 性的更关键行为因素。

