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第46卷第4期 陈语悉,高 翔,许 洁,等. 移植肾病理指标对不同时期移植肾功能异常的预测价值[J].
2026年4月 南京医科大学学报(自然科学版),2026,46(4):577-586 ·581 ·
表2 与活检时移植肾功能异常有关的多因素分析
Table 2 Multivariate analysis associated with abnormal graft function at biopsy
Characteristic Regression coefficient S.E Z P OR(95%CI)
HLA⁃I antibody MFI[M(P25,P75)] 0.00 0.00 -1.57 0.116 1.00(1.00-1.00)
i score[n(%)]
0 1.00
≥1 1.00 0.45 -2.21 0.027 2.73(1.12-6.63)
ptc score[n(%)]
0 1.00
≥1 0.86 0.45 -1.90 0.057 2.35(0.97-5.69)
OR:odds ratio;CI:confidence interval.
表3 与活检后第1年移植肾功能异常有关的多因素分析
Table 3 Multivariate analysis associated with abnormal graft function in the first year of post⁃biopsy
Characteristic Regression coefficient S.E Z P OR(95%CI)
i score[n(%)]
0 1.00
≥1 01.25 0 000.42 2.97 0.003 3.50(1.53-8.01)
History of rejection[n(%)]
No 1.00
Yes 17.40 1 032.04 0.02 0.987 36 151 160.57(0.00-Inf)
DGF:delayed graft function.
0 10 20 30 40 50 60 70 80 90 100
Points
1
i score
0
1
History of rejection
0
Total points
0 10 20 30 40 50 60 70 80 90 100 110 120
Risk
0.3 0.5 0.7 0.9
图1 活检后第1年移植肾功能异常发生风险的列线图模型
Figure 1 Nomogram model for the risk of abnormal graft function in the first year of post⁃biopsy
A B
1.0 1.0
0.8 0.8
Sensitivity 0.6 Actual probaility 0.6
0.4
0.4
0.2 0.2 Apparent
Bias⁃corrected
AUC:0.690(0.607-0.773) Ideal
0 0
.0 0.2 0.4 0.6 0.8 1.0 .0 0.2 0.4 0.6 0.8 1.0
1-Speciticity Nomogram predicted probaility
A:ROC curve of the nomogram model in the first year of post⁃biopsy. B:Calibration curve of the nomogram model in the first year of post⁃biopsy.
图2 活检后第1年列线图模型的ROC曲线与校准曲线
Figure 2 ROC curve and calibration curve of the nomogram model in the first year of post⁃biopsy

