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[39]GUIÈZE R,LIU V M,ROSEBROCK D,et al. Mitochon⁃ Glutaminolysis is a metabolic dependency in FLT3 ITD
drial reprogramming underlies resistance to BCL⁃2 inhibi⁃ acute myeloid leukemia unmasked by FLT3 tyrosine ki⁃
tion in lymphoid malignancies[J]. Cancer Cell,2019,36 nase inhibition[J]. Blood,2018,131(15):1639-1653
(4):369-384 [51]KOLBA M D,DUDKA W,ZAREBA⁃KOZIOŁ M,et al.
[40]ZHOU H M,ZHANG J G,ZHANG X,et al. Targeting can⁃ Tunneling nanotube ⁃ mediated intercellular vesicle and
cer stem cells for reversing therapy resistance:mecha⁃ protein transfer in the stroma ⁃ provided imatinib resis⁃
nism,signaling,and prospective agents[J]. Signal Trans⁃ tance in chronic myeloid leukemia cells[J]. Cell Death
duct Target Ther,2021,6(1):62 Dis,2019,10(11):817
[41]CHEN C L,UTHAYA KUMAR D B,PUNJ V,et al. [52]ROCA⁃PORTOLES A,RODRIGUEZ⁃BLANCO G,SUMP⁃
NANOG metabolically reprograms tumor⁃initiating stem⁃ TON D,et al. Venetoclax causes metabolic reprogram⁃
like cells through tumorigenic changes in oxidative phos⁃ ming independent of BCL ⁃ 2 inhibition[J]. Cell Death
phorylation and fatty acid metabolism[J]. Cell Metab, Dis,2020,11(8):616
2016,23(1):206-219 [53]ZHANG Y,ZHANG X,YANG X,et al. EGFR⁃TKIs in⁃
[42]NAIK P P,MUKHOPADHYAY S,PANDA P K,et al. Au⁃ duced DPP4 drives metabolic reprogramming of persister
tophagy regulates cisplatin⁃induced stemness and chemo⁃ cells in lung cancer[J]. Adv Sci(Weinh),2025,12(31):
resistance via the upregulation of CD44,ABCB1 and e06950
ADAM17 in oral squamous cell carcinoma[J]. Cell Prolif, [54]WU B,XIONG J,ZHOU Y,et al. Luteolin enhances
2018,51(1):e12411 TRAIL sensitivity in non ⁃ small cell lung cancer cells
[43]IKEDA K,HORIE⁃INOUE K,SUZUKI T,et al. Mitochon⁃ through increasing DR5 expression and Drp1 ⁃ mediated
drial super complex assembly promotes breast and endo⁃ mitochondrial fission[J]. Arch Biochem Biophys,2020,
metrial tumorigenesis by metabolic alterations and en⁃ 692:108539
hanced hypoxia tolerance[J]. Nat Commun,2019,10(1): [55]HE P,FENG J J,XIA X T,et al. Discovery of a potent and
4108 oral available complex I OXPHOS inhibitor that abrogates
[44]GONG Y,JI P,YANG Y S,et al. Metabolic ⁃ pathway ⁃ tumor growth and circumvents MEKi resistance[J]. J
based subtyping of triple ⁃ negative breast cancer reveals Med Chem,2023,66(9):6047-6069
potential therapeutic targets[J]. Cell Metab,2021,33 [56]XIN Q,JI Q H,ZHANG Y,et al. Aberrant ROS served as
(1):51-64 an acquired vulnerability of cisplatin⁃resistant lung can⁃
[45]LUO M,FU A F,WU R F,et al. High expression of G6PD cer[J]. Oxid Med Cell Longev,2022,2022:1112987
increases doxorubicin resistance in triple negative breast [57]XIA W J,QI X,LI M F,et al. Metformin promotes antican⁃
cancer cells by maintaining GSH level[J]. Int J Biol Sci, cer activity of NK cells in a p38 MAPK dependent man⁃
2022,18(3):1120-1133 ner[J]. Oncoimmunology,2021,10(1):1995999
[46]WINTER M,NAIT ELDJOUDI A,GUETTE C,et al. Mito⁃ [58]FUHR V,HEIDENREICH S,SRIVASTAVA M,et al.
chondrial adaptation decreases drug sensitivity of persis⁃ CD52 and OXPHOS⁃potential targets in ibrutinib⁃treated
tent triple negative breast cancer cells surviving combina⁃ mantle cell lymphoma[J]. Cell Death Discov,2022,8
tory and sequential chemotherapy[J]. Neoplasia,2023, (1):505
46:100949 [59]BARAN N,LODI A,DHUNGANA Y,et al. Inhibition of
[47]EVANS K W,YUCA E K,SCOTT S S,et al. Oxidative mitochondrial complex Ⅰ reverses NOTCH1⁃driven meta⁃
phosphorylation is a metabolic vulnerability in chemothe⁃ bolic reprogramming in T⁃cell acute lymphoblastic leuke⁃
rapy ⁃ resistant triple ⁃ negative breast cancer[J]. Cancer mia[J]. Nat Commun,2022,13(1):2801
Res,2021,81(21):5572-5581 [60]CHEN D W,BARSOUMIAN H B,FISCHER G,et al.
[48]ABRAHAM A,QIU S W,CHACKO B K,et al. SIRT1 regu⁃ Combination treatment with radiotherapy and a novel oxi⁃
lates metabolism and leukemogenic potential in CML dative phosphorylation inhibitor overcomes PD ⁃ 1 resis⁃
stem cells[J]. J Clin Invest,2019,129(7):2685-2701 tance and enhances antitumor immunity[J]. J Immunother
[49]FORTE D,GARCÍA⁃FERNÁNDEZ M,SÁNCHEZ⁃AGU⁃ Cancer,2020,8(1):e000289
ILERA A,et al. Bone marrow mesenchymal stem cells [61]VITIELLO G A,MEDINA B D,ZENG S,et al. Mitochon⁃
support acute myeloid leukemia bioenergetics and enhance drial inhibition augments the efficacy of imatinib by reset⁃
antioxidant defense and escape from chemotherapy[J]. ting the metabolic phenotype of gastrointestinal stromal tu⁃
Cell Metab,2020,32(5):829-843 mor[J]. Clin Cancer Res,2018,24(4):972-984
[50]GALLIPOLI P,GIOTOPOULOS G,TZELEPIS K,et al. [62]GIARRIZZO M ,LACOMB J F ,PATEL H R ,et al.

