Page 111 - 南京医科大学自然版
P. 111
第46卷第9期 吴法然,孙书宏,葛 新. 铜元素体内代谢机制及其在相关疾病中的作用与治疗潜力[J].
2026年9月 南京医科大学学报(自然科学版),2026,46(9):1366-1382 ·1381 ·
[18]LAN Y Q,WU S L,WANG Y H,et al. Association be⁃ copper and stroke risk factors in adults:evidence from the
tween blood copper and nonalcoholic fatty liver disease national health and nutrition examination survey,2011-
according to sex[J]. Clin Nutr,2021,40(4):2045-2052 2016[J]. Biol Trace Elem Res,2022,200(3):1089-
[19]CHEN H R,LI D X,ZHANG H M,et al. Mechanisms of 1094
copper metabolism and cuproptosis:implications for liver [31]XING L W,WANG Z F,HAO Z H,et al. Cuproptosis in
diseases[J]. Front Immunol,2025,16:1633711 stroke:focusing on pathogenesis and treatment[J]. Front
[20]FANG R R,YANG Q F,ZHAO J,et al. A novel signature Mol Neurosci,2024,17:1349123
combing cuproptosis⁃ and ferroptosis⁃related genes in non⁃ [32]ZHAO Y,SONG Y Y,CHANG S Q,et al. Acupuncture in⁃
alcoholic fatty liver disease[J]. Chung Kuo I Hsueh K’o hibits cuproptosis to prolong the time window of thromboly⁃
Hsueh Tsa Chih,2024,39(4):261-272 sis by down⁃regulating cerebral FDX1 and DLAT in rats
[21]TIAN H Y,SUN S J,QIU X R,et al. Diallyl trisulfide with cerebral infarction[J]. Acupunct Res,2025,50(7):
from garlic regulates RAB18 phase separation to inhibit li⁃ 754-762
pophagy and induce cuproptosis in hepatic stellate cells [33]ZHANG D D,ZHANG Q,WANG Y,et al. Identification
for antifibrotic effects[J]. Adv Sci(Weinh),2025,12 and immunological characterization of cuproptosis⁃related
(21):e2415325 molecular clusters in cardioembolic stroke[J]. Medicine,
[22]CONG C,CONG H,YAO Y,et al. Copper homeostasis 2025,104(33):e43747
and cuproptosis in Alzheimer’s disease(review)[J]. Int J [34]BOMER N,PAVEZ⁃GIANI M G,GROTE BEVERBORG
Mol Med,2025,56(5):172 N,et al. Micronutrient deficiencies in heart failure:mito⁃
[23]XIONG W J,LUO Z K,WANG H,et al. Amyloid beta 42 chondrial dysfunction as a common pathophysiological
disrupts cardiac function in Alzheimer’s disease mice via mechanism?[J]. J Intern Med,2022,291(6):713-731
SLC31A1 upregulation ⁃ mediated cuproptosis[J]. Basic [35]KUNUTSOR S K,VOUTILAINEN A,LAUKKANEN J A.
Res Cardiol,2026,121(2):285-299 Serum copper⁃to⁃zinc ratio and risk of incident pneumo⁃
[24]HE D,WANG X L,HAO M,et al. Mutational and tran⁃ nia in Caucasian men:a prospective cohort study[J]. Bio⁃
scriptional profiling of cuproptosis ⁃ associated genes in metals,2022,35(5):921-933
amyotrophic lateral sclerosis[J]. Genes Dis,2025,12 [36]KUNUTSOR S K,VOUTILAINEN A,KURL S,et al. Se⁃
(1):101208 rum copper⁃to⁃zinc ratio is associated with heart failure
[25]WANG N,XU X W,LI H L,et al. Atherosclerotic lesion⁃ and improves risk prediction in middle ⁃ aged and older
specific copper delivery suppresses atherosclerosis in high⁃ Caucasian men:a prospective study[J]. Nutr Metab Car⁃
cholesterol ⁃ fed rabbits[J]. Exp Biol Med(Maywood), diovasc Dis,2022,32(8):1924-1935
2021,246(24):2671-2678 [37]SHEN Z,LIU Z C,CAI S Q,et al. Copper homeostasis
[26]SUDHAHAR V,XIAO Z,DAS A,et al. Endothelial Cu and cuproptosis in myocardial infarction:molecular mecha⁃
uptake transporter CTR1 senses disturbed flow to promote nisms,treatment strategies and potential therapeutic tar⁃
atherosclerosis through cuproptosis[PP/OL]. bioRxiv gets[J]. Front Pharmacol,2025,16:1525585
(2025⁃01⁃28)[2025⁃10⁃30]. http://doi.org/:2025.01.27. [38]HUANG K,DING S F,XU X Y,et al. ISLR as a cupropto⁃
634587 sis⁃related predictor and therapeutic target in heart fail⁃
[27]YANG S J,LI Y J,ZHOU L J,et al. Copper homeostasis ure:a multi⁃omics and bioinformatics approach[J]. J In⁃
and cuproptosis in atherosclerosis:metabolism,mecha⁃ flamm Res,2025,18:9699-9716
nisms and potential therapeutic strategies[J]. Cell Death [39]MEDICI V,SARODE G V,NAPOLI E,et al. mtDNA de⁃
Discov,2024,10(1):25 pletion ⁃ like syndrome in Wilson disease[J]. Liver Int,
[28]MIRONCZUK A,KAPICA⁃TOPCZEWSKA K,SOCHA K, 2020,40(11):2776-2787
et al. Selenium,copper,zinc concentrations and Cu/Zn, [40]SHRIBMAN S,POUJOIS A,BANDMANN O,et al. Wil⁃
Cu/Se molar ratios in the serum of patients with acute son’s disease:update on pathogenesis,biomarkers and
ischemic stroke in northeastern Poland⁃a new insight into treatments[J]. J Neurol Neurosurg Psychiatry,2021,92
stroke pathophysiology[J]. Nutrients,2021,13(7):2139 (10):1053-1061
[29]YANG L X,CHEN X,CHENG H L,et al. Dietary copper [41]CHEN H,WANG X,XING J,et al. Role and mechanisms
intake and risk of stroke in adults:a case⁃control study of cuproptosis in the pathogenesis of Wilson’s disease
based on national health and nutrition examination survey (review)[J]. Int J Mol Med,2025,56(2):117
2013-2018[J]. Nutrients,2022,14(3):409 [42]BINESH A,VENKATACHALAM K. Copper in human
[30]XU J G,XU G F,FANG J K. Association between serum health and disease:a comprehensive review[J]. J Bio⁃

