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表1 脂滴⁃线粒体接触点在肝脏代谢损伤与缺血再灌注损伤中的重要研究成果归纳
Table 1 Summary of important research results on lipid droplet mitochondrial contact points in liver metabolic injury and
ischemia⁃reperfusion injury

Key molecules/ Significance related to liver Main
Research topic Main research conclusion
phenomena disease references
Basic structural pat⁃ Dynamic contact，Lipid droplet mitochondrial contact is not Provide structural basis for ［9-10］
tern of contact points anchoring sample randomly adjacent，but a functional microdo⁃ subsequent lipid transport，en⁃
contact main regulated by nutritional status，tissue ergy allocation，and stress res⁃
type，and metabolic needs ponse
Core tethering pro⁃ PLIN5 PLIN5 is located on the surface of lipid drop⁃ It is the core entry point for un⁃ ［3］
tein lets，promoting physical and metabolic cou⁃ derstanding the coupling be⁃
pling between lipid droplets and mitochon⁃ tween lipid droplet lipolysis
dria，and is currently the most extensively and mitochondrial substrate
supported key bridging molecule utilization

Ternary interactive MIGA2 MIGA2 can simultaneously connect mito⁃ Expanded the mechanism hier⁃ ［12］
network chondria，endoplasmic reticulum，and lipid archy of liver cell lipid droplet
droplets，indicating that lipid droplet mito⁃ contact research
chondrial contact is not an isolated binary
structure，but can be incorporated into larger
organelle interaction networks
Contact points are Mfn2 and mito⁃ The attachment of mitochondria to lipid drop⁃ The function of the contact ［13-14］
regulated by mito⁃ chondrial fusion lets and the effective transport of fatty acids point is not only determined by
chondrial dynamics state from lipid droplets depend on the dynamic the tethering protein，but also
state of mitochondria，and impaired fusion controlled by the mitochondrial
can lead to an imbalance in fatty acid utiliza⁃ state
tion
Localmetaboliccom⁃ ACSL1，CPT1a， A local metabolic complex is formed near the Explained why contact points ［15-16］
plex promotes fatty VDAC contact site for fatty acid activation and mito⁃ can determine lipid fate and
acid utilization chondrial uptake，which enhances the spatial energy allocation
efficiency of β⁃oxidation
Organizational het⁃ PDM/LD related Mitochondria attached to lipid droplets in Supported the contact point in ［4，17］
erogeneity of con⁃ mitochondria brown adipose tissue tend to support lipid the liver to be closer to the“li⁃
tact points droplet amplification and reesterification；potoxicity buffer oxidative
mitochondria related to lipid droplets in the shunt platform”
liver are more inclined towards fatty acid oxi⁃
dation
Early compensation Mitochondrial res⁃ The compensatory enhancement of liver mito⁃ Supported a phased framework ［6，20］
of MASLD piratory compen⁃ chondrial function during the stage of simple of“early compensation and lat⁃
sation fatty liver suggests that lipid droplet mito⁃ er imbalance”
chondrial coupling may have adaptive signifi⁃
cance in the early stages
Contact reshaping PDM features are The correlation between contact patterns and The value of strengthening ［7，29］
in the progress of related to the se⁃ the severity of MASLD suggests that its touchpoints as nodes for dis⁃
MASLD verity of the dis⁃ changes may not be accompanying phenome⁃ ease stratification and mecha⁃
ease na，but rather an important component of dis⁃ nism stratification
ease progression