Page 54 - 南京医科大学自然科学版第1期
P. 54
第41卷第1期
· 48 · 南 京 医 科 大 学 学 报 2021年1月
of adult neural stem cells and the birth of neurons in Al⁃ pact of natural compounds on S⁃shaped Aβ42 fibril:from
zheimer’s disease mice via notch signaling pathway[J]. molecular docking to biophysical characterization[J]. Int
Cell Reprogram,2019,21(3):152-161 J Mol Sci,2020,21(6):2017
[7] YAGISHITA S,SUZUKI S,YOSHIKAWA K,et al. Treat⁃ [18] SAHA P,SARKAR S,PAIDI R K,et al. TIMP⁃1:a key
ment of intermittent hypoxia increases phosphorylated tau cytokine released from activated astrocytes protects neu⁃
in the hippocampus via biological processes common to rons and ameliorates cognitive behaviours in a rodent
aging[J]. Mol Brain,2017,10(1):2 model of Alzheimer’s disease[J]. Brain Behav Immun,
[8] MAJD S,POWER J H,KOBLAR S A,et al. Early glyco⁃ 2020,87:804-819
gen synthase kinase⁃3β and protein phosphatase 2A inde⁃ [19] KUHN A J,RASKATOV J. Is the p3 peptide(Aβ17⁃40,
pendent tau dephosphorylation during global brain isch⁃ Aβ17⁃42)relevant to the pathology of Alzheimer’s dis⁃
aemia and reperfusion following cardiac arrest and the ease?[J]. J Alzheimers Dis,2020,74(1):43-53
role of the adenosine monophosphate kinase pathway[J]. [20] HUANG L,ZHONG X,QIN S,et al. Protocatechuic acid
Eur J Neurosci,2016,44(3):1987-1997
attenuates β⁃secretase activity and okadaic acid⁃induced
[9] KAMAT P K,KALANI A,RAI S,et al. Mechanism of oxi⁃
autophagy via the Akt/GSK⁃3β/MEF2D pathway in PC12
dative stress and synapse dysfunction in the pathogenesis
cells[J]. Mol Med Rep,2020,21(3):1328-1335
of Alzheimer’s disease:understanding the therapeutics
[21] KWAK S S,WASHICOSKY K J,BRAND E,et al. Amy⁃
strategies[J]. Mol Neurobiol,2016,53(1):648-661
loid⁃β42/40 ratio drives tau pathology in 3D human neu⁃
[10] NILSON A,ENGLISH K C,GERSON J E,et al. Tau oligo⁃
ral cell culture models of Alzheimer’s disease[J]. Nat
mers associate with inflammation in the brain and retina
Commun,2020,11(1):1377
of tauopathy mice and in neurodegenerative diseases[J].
[22] SHEHZAD A,WAHID F,LEE Y S. Curcumin in cancer
J Alzheimers Dis,2017,55(3):1083-1099
chemoprevention:molecular targets,pharmacokinetics,
[11] KOVACS G G,FERRER I,GRINBERG L T,et al. Aging⁃
bioavailability,and clinical trials[J]. Arch Pharm,2010,
related tau astrogliopathy(ARTAG):harmonized evalua⁃
343(9):489-499
tion strategy[J]. Acta Neuropathol,2016,131(1):87-
[23] JAMDADE V S,MUNDHE N,KUMAR P,et al. Raloxi⁃
102
fene inhibits NF⁃kB pathway and potentiates anti⁃tumour
[12] ADLER D H,WISSE L,ITTYERAH R,et al. Characteriz⁃
activity of cisplatin with simultaneous reduction in its
ing the human hippocampus in aging and Alzheimer’s
nephrotoxictiy[J]. Pathol Oncol Res,2016,22(1):145-
disease using a computational Atlas derived from ex vivo
153
MRI and histology[J]. Proc Natl Acad Sci U S A,2018,
[24] XU M X,YU R,SHAO L F,et al. Up⁃regulated fractalkine
115(16):4252-4257
(FKN)and its receptor CX3CR1 are involved in fructose⁃
[13] SAVELIEFF M G,LEE S,LIU Y,et al. Untangling amy⁃
induced neuroinflammation:Suppression by curcumin
loid⁃β,tau,and metals in Alzheimer’s disease[J]. ACS
[J]. Brain Behav Immun,2016,58(58):69-81
Chem Biol,2013,8(5):856-865
[25] HUANG L,LIN M,ZHONG X,et al. Galangin decreases p
[14] MARIANO M,SCHMITT C,MIRALINAGHI P,et al.
⁃ tau,Aβ42 and β ⁃ secretase levels,and suppresses au⁃
First selective dual inhibitors of tau phosphorylation and
tophagy in okadaic acid⁃induced PC12 cells via an Akt/
Beta ⁃ amyloid aggregation,two major pathogenic mecha⁃
nisms in Alzheimer’s disease[J]. ACS Chem Neurosci, GSK3β/mTOR signaling⁃dependent mechanism[J]. Mol
Med Rep,2019,19(3):1767-1774
2014,5(12):1198-1202
[26] FANG B,ZHAO Q,LING W,et al. Hypoxia induces HT⁃
[15] SUN L,LIU S Y,ZHOU X W,et al. Inhibition of protein
22 neuronal cell death via Orai1/CDK5 pathway⁃mediat⁃
phosphatase 2A⁃ and protein phosphatase 1⁃induced tau
ed Tau hyperphosphorylation[J]. Am J Transl Res,2019,
hyperphosphorylation and impairment of spatial memory
11(12):7591-7603
retention in rats[J]. Neuroscience,2003,118(4):1175-
[27] LI H Q,IP S P,YUAN Q J,et al. Isorhynchophylline ame⁃
1182
[16] WANG Y,SONG X,LIU D,et al. IMM ⁃ H004 reduced liorates cognitive impairment via modulating amyloid pa⁃
thology,tau hyperphosphorylation and neuroinflamma⁃
okadaic acid⁃induced neurotoxicity by inhibiting Tau pa⁃
tion:studies in a transgenic mouse model of Alzheimer’s
thology in vitro and in vivo[J]. Neurotoxicology,2019,75
(75):221-232 disease[J]. Brain Behav Immun,2019,82(82):264-278
[17] MUSCAT S,PALLANTE L,STOJCESKI F,et al. The im⁃ [收稿日期] 2020-02-24