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南京医科大学学报（自然科学版） 第41卷第10期
·1474 · Journal of Nanjing Medical University（Natural Sciences） 2021年10月

·临床医学·

OCT观察PCI术后可降解及永久性聚合物药物涂层支架内新生

内膜增生的差异

朱琳琳，孟培娜，尤 威，吴志明，叶 飞，谢渡江 *
南京医科大学附属南京医院（南京市第一医院）心血管内科，江苏 南京 210006

［摘 要］ 目的：通过光学相干断层显像（optical coherence tomography，OCT）观察经皮冠状动脉介入治疗（percutaneous coro⁃
nary intervention，PCI）术后1年，聚合物可降解药物涂层支架（Firehawk）与永久性聚合物药物涂层支架（Xience系列）内新生内
膜增生的差异，旨在观察可降解聚合物及永久性聚合物对支架内新生内膜增生的影响。方法：本研究为单中心、回顾性设计，
入选2014年1月—2019年6月在南京市第一医院心内科行PCI术且术后1年有冠脉造影+OCT检查资料的患者；依据术中植入
的药物涂层支架的不同类型分为 Firehawk 组和 Xience 组；比较两组临床基线资料、PCI 术中参数及术后复查 OCT 的相关指
标。结果：本研究共入选106例患者，其中Firehawk组52例，Xience组54例。两组患者的临床基线资料（包括年龄、性别、高血
压病史、糖尿病史、吸烟史、血脂指标以及药物如阿司匹林、氯吡格雷/替格瑞洛、他汀、β受体阻滞剂、ACEI/ARB服用史）在PCI
术前及术后1年差异无统计学意义（P > 0.05）；两组患者PCI术中参数（包括靶血管分布、支架直径及长度、预扩及后扩比例、最
大预扩/后扩球囊直径、最大预扩/后扩压力）差异无统计学意义（P > 0.05）；术后1年复查OCT提示，两组患者的支架内增生情
况（包括最大新生内膜厚度、最大新生内膜面积、最小管腔面积、最小管腔直径、再狭窄率、同质性比例）差异无统计学意义
（P > 0.05）。结论：聚合物可降解与永久性聚合物药物涂层支架植入术后1年，支架内新生内膜增生的性质特点类似。
［关键词］ 光学相干断层显像；聚合物可降解药物涂层支架；永久性聚合物药物涂层支架；支架内增生
［中图分类号］ R542.2 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）10⁃1474⁃06
doi：10.7655/NYDXBNS20211009

Differences of biodegradable polymer drug⁃eluting stents versus permanent polymer drug⁃
eluting stents on neointimal hyperplasia from optical coherence tomography observations
after percutaneous coronary intervention

ZHU Linlin，MENG Peina，YOU Wei，WU Zhiming，YE Fei，XIE Dujiang *
Department of Cardiology，the Affiliated Nanjing Hospital of Nanjing Medical University（Nanjing First Hospital），
Nanjing 210006，China

［Abstract］ Objective： The aim of this study is to compare the effect of biodegradable polymer drug⁃eluting stents（Firehawk）versus
permanent polymer drug ⁃ eluting stents（Xience）on neointimal hyperplasia at one ⁃ year follow ⁃ up after percutaneous coronary
intervention（PCI）from optical coherence tomography（OCT）observations. Method： This was a retrospective single center study，
patients who had Firehawk/Xience stents during PCI in our center from January 2014 to June 2019 were included in the trial，and they
were divided into two groups：Firehawk group and Xience group. At one ⁃ year follow ⁃ up，we compared the difference of in ⁃ stent
neointimal hyperplasia from OCT observations between the two groups. Results： Totally 106 patients were finally enrolled，including 52
patients who were in the Firehawk group and 54 who were in the Xience group. There were no differences of clinical characteristics
before PCI and at one⁃year follow⁃up between the two groups（P > 0.05）. There were no differences of parameters during PCI（target
vessel，diameter and length of stent，pre⁃dilation and post⁃dilation，maximum diameter/pressure of dilated⁃balloons）between the two
groups（P > 0.05）. At one⁃year follow⁃up，in⁃stent neointimal hyperplasia（maximum neointimal thickness，maximum neointimal area，
minimum luminal area，minimum luminal diameter，restenosis rates and percentage of homogeneous property）was also similar between
the two groups（P > 0.05）. Conclusion： It is similar of vascular response to biodegradable polymer drug⁃eluting stents and permanent
［基金项目］ 南京市医学科技发展项目（YKK17106）
∗
通信作者（Corresponding author），E⁃mail： xdjxdjxdjxdj@126.com