Page 67 - 第10期

第41卷第10期 南京医科大学学报（自然科学版）
2021年10月 Journal of Nanjing Medical University（Natural Sciences） ·1485 ·

·临床医学·

ABVD化疗方案对霍奇金淋巴瘤患者睾丸 F⁃FDG代谢的影响
18

李洋洋，丁其勇，李天女，唐立钧
南京医科大学第一附属医院核医学科，江苏 南京 210029

［摘 要］ 目的：探讨ABVD（阿霉素、博来霉素、长春碱、氮烯咪胺，简称ABVD）方案化疗对霍奇金淋巴瘤（Hodgkin’s lympho⁃
18
18
ma，HL）患者睾丸氟代脱氧葡萄糖（ F⁃FDG）代谢的影响。方法：回顾性分析34例（均行6个疗程的ABVD方案化疗）利用 F⁃
FDG PET/CT进行疗效评估的HL患者资料。收集患者4次行 F⁃FDG PET/CT检查时（基线期及每2次疗程化疗行一次检查）的
18
血糖、体重、注射剂量、注射时间、睾丸及纵隔血池的最大标准摄取值（SUVmax）。分析HL患者在4次 F⁃FDG PET/CT 检查后
18
睾丸 F⁃FDG 代谢的变化情况。结果：34 例 HL 患者 4 次 F⁃FDG PET/CT 检查中仅睾丸 SUVmax 和体重的差异有统计学意义
18
18
（P=0.017，P=0.001）。HL 患者第 2 次 PET/CT 检查时的睾丸 SUVmax 较第 1 次减低了 0.998，P=0.045；但第 3、4 次睾丸 SUVmax
与第 1 次无明显差异，并且后 3 次 PET/CT 检查时睾丸 SUVmax 未见明显变化（P＞0.05）。患者在第 1 次 PET/CT 检查时（基线
期）的睾丸 SUVmax 与纵隔血池 SUVmax 之间存在正相关（r=0.51，P=0.002），而睾丸 SUVmax 与年龄之间无相关性（P=0.646）。
患者在后 3 次 PET/CT 检查时的体重均较第 1 次增高（P=0.009，0.004，0.016），但未发现后 3 次检查时患者的体重有明显变化
（P＞0.05）。结论：在接受ABVD方案化疗的HL患者中，睾丸的 F⁃FDG代谢程度在化疗过程中存在一过性减低，但后期可恢
18
复；因此ABVD化疗方案可能对HL患者睾丸糖代谢的影响不大。
［关键词］ 霍奇金淋巴瘤；化疗；PET/CT；睾丸 F⁃FDG代谢
18
［中图分类号］ R730.53 ［文献标志码］ A ［文章编号］ 1007⁃4368（2021）10⁃1485⁃05
doi：10.7655/NYDXBNS20211011

The impact of ABVD chemotherapy regime on testicular F⁃FDG uptake in patients with
18
Hodgkin’s lymphoma

LI Yangyang，DING Qiyong，LI Tiannü，TANG Lijun
Department of Nuclear Medicine，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China

［Abstract］ Objective：To investigate the impact of ABVD（adriamycin，bleomycin，vinblastine，dacarbazine）chemotherapy regime
18
on the testicular F⁃fluorodeoxyglucose（FDG）uptake in patients with Hodgkin’s lymphoma（HL）. Methods：Thirty⁃four patients at
18
diagnosis monitored with F⁃FDG on positron emission tomography（PET）/computed tomography（CT）to assess treatment response for
18
HL were selected for this retrospective analysis. The patients received ABVD chemotherapy regimen for six courses. The four F⁃FDG
PET/CT examinations were performed at baseline and after every two courses of chemotherapy. Blood glucose，body weight，injection
dose and injection time were collected，and the maximum standardized uptake value（SUVmax）of testis and mediastinal blood pool
18 18
were measured. The changes of testicular F⁃FDG uptake in patients with HL after four F⁃FDG PET/CT examinations were analyzed.
Results：There were statistical significance in testis SUVmax and weight（P=0.017，0.001）at four PET/CT examinations for 34 cases
with HL. Compared with the testicular SUVmax at the first PET/CT examination，the testicular SUVmax at the second time decreased
by 0.998，P=0.045. There were no significant differences in testicular SUVmax between the last two time points and the first time or
over the course of chemotherapy（P＞0.05）. The testis SUVmax were found to be positively correlated with mediastinal blood pool
SUVmax at the first PET/CT examination（baseline）（r=0.51，P=0.002），but not with age（P=0.646）. The weight at last three PET/CT
was higher than at the first time（P=0.009，0.004，0.016），but no changes were found during at last three PET/CT examinations（P >
18
0.05）. Conclusion：For patients undergoing ABVD chemotherapy regime for Hodgkin’s lymphoma，the testicular F⁃FDG uptake
decreased temporarily over the course of chemotherapy，but recovered in the later. Therefore，ABVD chemotherapy regime may have
little effect on testicular glycometabolism of patients with Hodgkin’s lymphoma.
18
［Key words］ Hodgkin’s lymphoma；chemotherapy；PET/CT；testicular F⁃FDG uptake
［J Nanjing Med Univ，2021，41（10）：1485⁃1489］